{"id":7686,"date":"2020-06-19T11:40:00","date_gmt":"2020-06-19T18:40:00","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=7686"},"modified":"2021-03-26T11:40:43","modified_gmt":"2021-03-26T18:40:43","slug":"potent-neutralizing-monoclonal-antibodies-directed-to-multiple-epitopes-on-the-sars-cov-2-spike","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/06\/19\/potent-neutralizing-monoclonal-antibodies-directed-to-multiple-epitopes-on-the-sars-cov-2-spike\/","title":{"rendered":"Potent Neutralizing Monoclonal Antibodies Directed to Multiple Epitopes on the SARS-CoV-2 Spike"},"content":{"rendered":"<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"43\" data-aria-posinset=\"1\" data-aria-level=\"1\"><i><span data-contrast=\"none\">[pre-print, not peer reviewed]<\/span><\/i><span data-contrast=\"auto\">\u00a0Among 16 SARS-CoV-2 neutralizing monoclonal antibodies from 5 patients with severe disease, 19 potently neutralized the virus\u00a0<\/span><i><span data-contrast=\"auto\">in vitro<\/span><\/i><span data-contrast=\"auto\">, 9 with exquisite potency. Several are promising candidates for treatment or prevention of COVID-19. These 19 antibodies were nearly equally divided between two regions at the top of the viral spike<\/span><span data-contrast=\"auto\">\u00a0\u2014<\/span><span data-contrast=\"auto\">\u00a0the receptor binding domain and the N-terminal domain<\/span><span data-contrast=\"auto\">\u00a0\u2014<\/span><span data-contrast=\"auto\">\u00a0demonstrating the immunogenicity of these regions.<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Ho et al. (June 18, 2020). Potent Neutralizing Monoclonal Antibodies Directed to Multiple Epitopes on the SARS-CoV-2 Spike.\u00a0<\/span><\/i><i><span data-contrast=\"none\">Pre-print downloaded June 19 from\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.1101\/2020.06.17.153486\"><span data-contrast=\"none\">https:\/\/doi.org\/10.1101\/2020.06.17.153486<\/span><\/a><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>[pre-print, not peer reviewed]\u00a0Among 16 SARS-CoV-2 neutralizing monoclonal antibodies from 5 patients with severe disease, 19 potently neutralized the virus\u00a0in vitro, 9 with exquisite potency. Several are promising candidates for treatment or prevention of COVID-19. These 19 antibodies were nearly equally divided between two regions at the top of the viral spike\u00a0\u2014\u00a0the receptor binding domain&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/06\/19\/potent-neutralizing-monoclonal-antibodies-directed-to-multiple-epitopes-on-the-sars-cov-2-spike\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[],"topic":[19],"class_list":["post-7686","post","type-post","status-publish","format-standard","hentry","category-article-summary","topic-testing-and-treatment"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/7686","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=7686"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/7686\/revisions"}],"predecessor-version":[{"id":7687,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/7686\/revisions\/7687"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=7686"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=7686"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=7686"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=7686"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}