{"id":7688,"date":"2020-06-19T11:40:55","date_gmt":"2020-06-19T18:40:55","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=7688"},"modified":"2021-03-26T11:41:37","modified_gmt":"2021-03-26T18:41:37","slug":"the-cardiac-toxicity-of-chloroquine-or-hydroxychloroquine-in-covid-19-patients-a-systematic-review-and-meta-regression-analysis","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/06\/19\/the-cardiac-toxicity-of-chloroquine-or-hydroxychloroquine-in-covid-19-patients-a-systematic-review-and-meta-regression-analysis\/","title":{"rendered":"The Cardiac Toxicity of Chloroquine or Hydroxychloroquine in COVID-19 Patients:\u00a0A Systematic Review and Meta-Regression Analysis"},"content":{"rendered":"<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"43\" data-aria-posinset=\"2\" data-aria-level=\"1\"><i><span data-contrast=\"none\">[pre-print, not peer reviewed]<\/span><\/i><span data-contrast=\"auto\">\u00a0A systematic review and meta-analysis (n=19 studies; 5,652 patients) studied the incidence of cardiac endpoints among COVID-19 patients treated with chloroquine or hydroxychloroquine, including QT prolongation\u2014a potential precursor to the arrhythmias\u00a0torsades\u00a0de pointes (TdP) or ventricular tachycardia (VT) or cardiac arrest\u2014as well as\u00a0TdP\/VT or cardiac arrest. The pooled incidence was 90 per 1,000 for prolonged QTc, 3 per 1,000 for\u00a0TdP\/VT or cardiac arrest, and 50 per 1,000 for discontinuation of either medication due to prolonged QTc or arrhythmias. Treatment of COVID-19 patients with chloroquine or hydroxychloroquine is associated with a substantial risk of QTc prolongation and its sequelae.<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Tleyjeh\u00a0et al. (June 18, 2020). The Cardiac Toxicity of Chloroquine or Hydroxychloroquine in COVID-19 Patients<\/span><\/i><i><span data-contrast=\"none\">:<\/span><\/i><i><span data-contrast=\"none\">\u00a0A Systematic Review and Meta-Regression Analysis.\u00a0<\/span><\/i><i><span data-contrast=\"none\">Pre-print downloaded June 19 from\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.1101\/2020.06.16.20132878\"><span data-contrast=\"none\">https:\/\/doi.org\/10.1101\/2020.06.16.20132878<\/span><\/a><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>[pre-print, not peer reviewed]\u00a0A systematic review and meta-analysis (n=19 studies; 5,652 patients) studied the incidence of cardiac endpoints among COVID-19 patients treated with chloroquine or hydroxychloroquine, including QT prolongation\u2014a potential precursor to the arrhythmias\u00a0torsades\u00a0de pointes (TdP) or ventricular tachycardia (VT) or cardiac arrest\u2014as well as\u00a0TdP\/VT or cardiac arrest. The pooled incidence was 90 per 1,000&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/06\/19\/the-cardiac-toxicity-of-chloroquine-or-hydroxychloroquine-in-covid-19-patients-a-systematic-review-and-meta-regression-analysis\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[],"topic":[20],"class_list":["post-7688","post","type-post","status-publish","format-standard","hentry","category-article-summary","topic-clinical-characteristics-and-health-care-setting"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/7688","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=7688"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/7688\/revisions"}],"predecessor-version":[{"id":7689,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/7688\/revisions\/7689"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=7688"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=7688"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=7688"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=7688"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}