{"id":7710,"date":"2020-06-22T12:00:30","date_gmt":"2020-06-22T19:00:30","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=7710"},"modified":"2021-03-26T12:01:15","modified_gmt":"2021-03-26T19:01:15","slug":"clinical-and-immunological-assessment-of-asymptomatic-sars-cov-2-infections","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/06\/22\/clinical-and-immunological-assessment-of-asymptomatic-sars-cov-2-infections\/","title":{"rendered":"Clinical and Immunological Assessment of Asymptomatic SARS-CoV-2 Infections"},"content":{"rendered":"<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"34\" data-aria-posinset=\"2019\" data-aria-level=\"1\"><span data-contrast=\"auto\">There was a longer duration of viral shedding<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">among a\u00a0<\/span><span data-contrast=\"auto\">group of 37 asymptomatic patients with\u00a0<\/span><span data-contrast=\"auto\">SARS-CoV-2 infection<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">in the\u00a0<\/span><span data-contrast=\"auto\">Wanzhou<\/span><span data-contrast=\"auto\">\u00a0District, China,\u00a0<\/span><span data-contrast=\"auto\">compared to a<\/span><span data-contrast=\"auto\">\u00a0paired symptomatic group (HR\u00a0<\/span><span data-contrast=\"auto\">1.69, 95%CI 1.06<\/span><span data-contrast=\"auto\">,\u00a0<\/span><span data-contrast=\"auto\">2.70<\/span><span data-contrast=\"auto\">)<\/span><span data-contrast=\"auto\">.<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"34\" data-aria-posinset=\"2019\" data-aria-level=\"1\"><span data-contrast=\"auto\">Asymptomatic individuals<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">had\u00a0<\/span><span data-contrast=\"auto\">significantly lower virus-specific IgG levels (median 3.4, IQR 1.6-10.7 vs. 20.5, 5.8-38.2; p = 0.005) in the acute phase<\/span><span data-contrast=\"auto\">\u00a0of infection<\/span><span data-contrast=\"auto\">. Asymptomatic individuals were more likely to have\u00a0<\/span><span data-contrast=\"auto\">a\u00a0<\/span><span data-contrast=\"auto\">reduction in neutralizing antibody levels (81% vs. 62%) and\u00a0<\/span><span data-contrast=\"auto\">to become seronegative\u00a0<\/span><span data-contrast=\"auto\">(40% vs. 1<\/span><span data-contrast=\"auto\">3<\/span><span data-contrast=\"auto\">%) during the early convalescent phase.<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"34\" data-aria-posinset=\"2019\" data-aria-level=\"1\"><span data-contrast=\"auto\">These data suggest that asymptomatic individuals\u00a0<\/span><span data-contrast=\"auto\">may mount a<\/span><span data-contrast=\"auto\">\u00a0weaker immune response to SARS-CoV-2 infection,\u00a0<\/span><span data-contrast=\"auto\">which could have\u00a0<\/span><span data-contrast=\"auto\">implications for immunity strateg<\/span><span data-contrast=\"auto\">ies<\/span><span data-contrast=\"auto\">\u00a0and serological surveys.<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Long et al. (June 18, 2020). Clinical and Immunological Assessment of Asymptomatic SARS-CoV-2 Infections. Nature Medicine.\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.1038\/s41591-020-0965-6\"><span data-contrast=\"none\">https:\/\/doi.org\/10.1038\/s41591-020-0965-6<\/span><\/a><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>There was a longer duration of viral shedding\u00a0among a\u00a0group of 37 asymptomatic patients with\u00a0SARS-CoV-2 infection\u00a0in the\u00a0Wanzhou\u00a0District, China,\u00a0compared to a\u00a0paired symptomatic group (HR\u00a01.69, 95%CI 1.06,\u00a02.70).\u00a0 Asymptomatic individuals\u00a0had\u00a0significantly lower virus-specific IgG levels (median 3.4, IQR 1.6-10.7 vs. 20.5, 5.8-38.2; p = 0.005) in the acute phase\u00a0of infection. Asymptomatic individuals were more likely to have\u00a0a\u00a0reduction in neutralizing antibody&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/06\/22\/clinical-and-immunological-assessment-of-asymptomatic-sars-cov-2-infections\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[],"topic":[21],"class_list":["post-7710","post","type-post","status-publish","format-standard","hentry","category-article-summary","topic-transmission"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/7710","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=7710"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/7710\/revisions"}],"predecessor-version":[{"id":7711,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/7710\/revisions\/7711"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=7710"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=7710"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=7710"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=7710"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}