{"id":7745,"date":"2020-06-23T12:23:42","date_gmt":"2020-06-23T19:23:42","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=7745"},"modified":"2021-03-26T12:35:26","modified_gmt":"2021-03-26T19:35:26","slug":"effectiveness-and-safety-of-glucocorticoids-to-treat-covid-19-a-rapid-review-and-meta-analysis","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/06\/23\/effectiveness-and-safety-of-glucocorticoids-to-treat-covid-19-a-rapid-review-and-meta-analysis\/","title":{"rendered":"Effectiveness and Safety of Glucocorticoids to Treat COVID-19:\u00a0A Rapid\u00a0Review and Meta-Analysis"},"content":{"rendered":"<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"43\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"auto\">A meta-analysis (n=23 studies, 1 RCT and 22 cohort studies; 13,815 patients) found the use of glucocorticoid<\/span><span data-contrast=\"auto\">\u00a0steroids<\/span><span data-contrast=\"auto\">\u00a0was associated with a non-significant increase in mortality (<\/span><span data-contrast=\"auto\">RR=<\/span><span data-contrast=\"auto\">2<\/span><span data-contrast=\"auto\">.00<\/span><span data-contrast=\"auto\">, 95%CI 0.69, 5.75<\/span><span data-contrast=\"auto\">)\u00a0<\/span><span data-contrast=\"auto\">and duration of hospitalization (<\/span><span data-contrast=\"auto\">increase of\u00a0<\/span><span data-contrast=\"auto\">2.4 days, 95%CI 1.4, 3.4) but significantly lower duration of fever (-3.23 days, 95%CI -3.56, -2.90). Heterogeneity was high across the included studies (I<\/span><span data-contrast=\"auto\">2<\/span><span data-contrast=\"auto\">\u00a084.6% to 97.9%), likely due to differences in patient characteristics and glucocorticoid protocols, suggesting pooled effect estimates\u00a0<\/span><span data-contrast=\"auto\">should be interpreted with caution<\/span><span data-contrast=\"auto\">.\u00a0<\/span><span data-contrast=\"auto\">[EDITORIAL NOTE: While the authors\u00a0<\/span><span data-contrast=\"auto\">use<\/span><span data-contrast=\"auto\">d<\/span><span data-contrast=\"auto\">\u00a0a technique to\u00a0downweight\u00a0the contribution of studies\u00a0<\/span><span data-contrast=\"auto\">with higher\u00a0<\/span><span data-contrast=\"auto\">potential for\u00a0<\/span><span data-contrast=\"auto\">bias (e.g., due to confounding),\u00a0<\/span><span data-contrast=\"auto\">they do not discuss the potential for confounding by indication, whereby the sickest patients may have been more likely to receive glucocorticoid treatment]<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Lu et al. (May 2020). Effectiveness and Safety of Glucocorticoids to Treat COVID-19:\u00a0A Rapid\u00a0Review and Meta-Analysis. Annals of Translational Medicine<\/span><\/i><span data-contrast=\"auto\">.\u00a0<\/span><a href=\"https:\/\/doi.org\/10.21037\/atm-20-3307\"><span data-contrast=\"none\">https:\/\/doi.org\/10.21037\/atm-20-3307<\/span><\/a><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A meta-analysis (n=23 studies, 1 RCT and 22 cohort studies; 13,815 patients) found the use of glucocorticoid\u00a0steroids\u00a0was associated with a non-significant increase in mortality (RR=2.00, 95%CI 0.69, 5.75)\u00a0and duration of hospitalization (increase of\u00a02.4 days, 95%CI 1.4, 3.4) but significantly lower duration of fever (-3.23 days, 95%CI -3.56, -2.90). Heterogeneity was high across the included studies&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/06\/23\/effectiveness-and-safety-of-glucocorticoids-to-treat-covid-19-a-rapid-review-and-meta-analysis\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[],"topic":[19],"class_list":["post-7745","post","type-post","status-publish","format-standard","hentry","category-article-summary","topic-testing-and-treatment"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/7745","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=7745"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/7745\/revisions"}],"predecessor-version":[{"id":7746,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/7745\/revisions\/7746"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=7745"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=7745"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=7745"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=7745"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}