{"id":7784,"date":"2020-06-24T12:48:42","date_gmt":"2020-06-24T19:48:42","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=7784"},"modified":"2021-03-26T12:49:32","modified_gmt":"2021-03-26T19:49:32","slug":"clinical-predictors-of-donor-antibody-titer-and-correlation-with-recipient-antibody-response-in-a-covid-19-convalescent-plasma-clinical-trial","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/06\/24\/clinical-predictors-of-donor-antibody-titer-and-correlation-with-recipient-antibody-response-in-a-covid-19-convalescent-plasma-clinical-trial\/","title":{"rendered":"Clinical Predictors of Donor Antibody Titer and Correlation with Recipient Antibody Response in a COVID-19 Convalescent Plasma Clinical Trial"},"content":{"rendered":"<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"34\" data-aria-posinset=\"1\" data-aria-level=\"1\"><i><span data-contrast=\"none\">[pre-print, not peer reviewed]<\/span><\/i><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">Madariaga<\/span><span data-contrast=\"auto\">\u00a0et al. investigated predictors of convalescent antibody production in 103\u00a0<\/span><span data-contrast=\"auto\">convalescent plasma donors<\/span><span data-contrast=\"auto\">\u00a0with\u00a0<\/span><span data-contrast=\"auto\">confirmed COVID-19<\/span><span data-contrast=\"auto\">\u00a0disease<\/span><span data-contrast=\"auto\">\u00a0and found that age, fever, absence of\u00a0<\/span><span data-contrast=\"auto\">myalgia,<\/span><span data-contrast=\"auto\">\u00a0fatigue,\u00a0<\/span><span data-contrast=\"auto\">AB\u00a0<\/span><span data-contrast=\"auto\">blood type<\/span><span data-contrast=\"auto\">,<\/span><span data-contrast=\"auto\">\u00a0and hospitalization were all associated with higher convalescent antibody titer to COVID-19.<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"34\" data-aria-posinset=\"2\" data-aria-level=\"1\"><span data-contrast=\"auto\">Most (8\/10) convalescent plasma recipients had significant increases in antibody levels post-transfusion<\/span><span data-contrast=\"auto\">.<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">A<\/span><span data-contrast=\"auto\">nti-receptor binding domain antibody titer increased on average 31% per day during the first three days post-transfusion (p=0.01) and anti-spike antibody titer increased by 40% (p<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">=0.02). Eight recipients\u00a0<\/span><span data-contrast=\"auto\">were discharged<\/span><span data-contrast=\"auto\">, one remained hospitalized, and one died.<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Madariaga<\/span><\/i><i><span data-contrast=\"none\">\u00a0et al. (June 23, 2020). Clinical Predictors of Donor Antibody Titer and Correlation with Recipient Antibody Response in a COVID-19 Convalescent Plasma Clinical Trial.\u00a0<\/span><\/i><i><span data-contrast=\"none\">Pre-print downloaded June 24 from<\/span><\/i><i><span data-contrast=\"none\">\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.1101\/2020.06.21.20132944\"><span data-contrast=\"none\">https:\/\/doi.org\/10.1101\/2020.06.21.20132944<\/span><\/a><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>[pre-print, not peer reviewed]\u00a0Madariaga\u00a0et al. investigated predictors of convalescent antibody production in 103\u00a0convalescent plasma donors\u00a0with\u00a0confirmed COVID-19\u00a0disease\u00a0and found that age, fever, absence of\u00a0myalgia,\u00a0fatigue,\u00a0AB\u00a0blood type,\u00a0and hospitalization were all associated with higher convalescent antibody titer to COVID-19.\u00a0 Most (8\/10) convalescent plasma recipients had significant increases in antibody levels post-transfusion.\u00a0Anti-receptor binding domain antibody titer increased on average 31% per&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/06\/24\/clinical-predictors-of-donor-antibody-titer-and-correlation-with-recipient-antibody-response-in-a-covid-19-convalescent-plasma-clinical-trial\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[],"topic":[19],"class_list":["post-7784","post","type-post","status-publish","format-standard","hentry","category-article-summary","topic-testing-and-treatment"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/7784","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=7784"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/7784\/revisions"}],"predecessor-version":[{"id":7785,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/7784\/revisions\/7785"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=7784"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=7784"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=7784"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=7784"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}