{"id":7849,"date":"2020-06-29T17:33:57","date_gmt":"2020-06-30T00:33:57","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=7849"},"modified":"2021-03-29T17:34:36","modified_gmt":"2021-03-30T00:34:36","slug":"safety-tolerability-and-pharmacokinetics-of-remdesivir-an-antiviral-for-treatment-of-covid-19-in-healthy-subjects","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/06\/29\/safety-tolerability-and-pharmacokinetics-of-remdesivir-an-antiviral-for-treatment-of-covid-19-in-healthy-subjects\/","title":{"rendered":"Safety, Tolerability, and Pharmacokinetics of\u00a0Remdesivir, an Antiviral for Treatment of COVID-19, in Healthy Subjects"},"content":{"rendered":"<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"43\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"auto\">Two phase I studies evaluating the safety and pharmacokinetics of single escalating and multiple intravenous (IV) doses of\u00a0remdesivir\u00a0in healthy subjects found all adverse events were grade 1 or 2 in severity (mild to moderate, with\u00a0<\/span><span data-contrast=\"auto\">only\u00a0<\/span><span data-contrast=\"auto\">minimal, local, or non-invasive treatment needed) and that once daily dosing is appropriate.<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Humeniuk et al. (June 2020). Safety, Tolerability, and Pharmacokinetics of\u00a0Remdesivir, an Antiviral for Treatment of COVID-19, in Healthy Subjects. Clinical and Translational Science.\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.1111\/cts.12840\"><span data-contrast=\"none\">https:\/\/doi.org\/10.1111\/cts.12840<\/span><\/a><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Two phase I studies evaluating the safety and pharmacokinetics of single escalating and multiple intravenous (IV) doses of\u00a0remdesivir\u00a0in healthy subjects found all adverse events were grade 1 or 2 in severity (mild to moderate, with\u00a0only\u00a0minimal, local, or non-invasive treatment needed) and that once daily dosing is appropriate.\u00a0 Humeniuk et al. (June 2020). Safety, Tolerability, and&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/06\/29\/safety-tolerability-and-pharmacokinetics-of-remdesivir-an-antiviral-for-treatment-of-covid-19-in-healthy-subjects\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[],"topic":[19],"class_list":["post-7849","post","type-post","status-publish","format-standard","hentry","category-article-summary","topic-testing-and-treatment"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/7849","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=7849"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/7849\/revisions"}],"predecessor-version":[{"id":7850,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/7849\/revisions\/7850"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=7849"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=7849"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=7849"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=7849"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}