{"id":7882,"date":"2020-06-30T17:50:10","date_gmt":"2020-07-01T00:50:10","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=7882"},"modified":"2021-03-29T17:50:57","modified_gmt":"2021-03-30T00:50:57","slug":"combination-of-antibody-based-rapid-diagnostic-tests-used-in-an-algorithm-may-improve-their-performance-in-sars-cov-2-diagnosis","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/06\/30\/combination-of-antibody-based-rapid-diagnostic-tests-used-in-an-algorithm-may-improve-their-performance-in-sars-cov-2-diagnosis\/","title":{"rendered":"Combination of Antibody Based Rapid Diagnostic Tests Used in an Algorithm May Improve Their Performance in SARS CoV-2 Diagnosis"},"content":{"rendered":"<ul>\n<li><i><span data-contrast=\"none\">[pre-print, not peer-reviewed]<\/span><\/i><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">Kushemererwa\u00a0et al. evaluated 13 rapid-diagnostic IgG\/IgM antibody tests for SARS-CoV-2\u00a0<\/span><span data-contrast=\"auto\">to inform the<\/span><span data-contrast=\"auto\">\u00a0development of a diagnostic algorithm\u00a0<\/span><span data-contrast=\"auto\">for use in settings where PCR-based\u00a0<\/span><span data-contrast=\"auto\">diagnostics<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">are not available<\/span><span data-contrast=\"auto\">.\u00a0<\/span><span data-contrast=\"auto\">PCR<\/span><span data-contrast=\"auto\">&#8211;<\/span><span data-contrast=\"auto\">positive samples used for the evaluation were collected 0-28 days after the patient was confirmed positive.\u00a0<\/span><span data-contrast=\"auto\">They<\/span><span data-contrast=\"auto\">\u00a0evaluated 78 possible combinations of 2 assays to be used in parallel.\u00a0<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"34\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"auto\">The individual sensitivities of the assays ranged from 18% to 74%.\u00a0<\/span><span data-contrast=\"auto\">The two<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">assays<\/span><span data-contrast=\"auto\">\u00a0with the\u00a0<\/span><span data-contrast=\"auto\">optimal combined performance<\/span><span data-contrast=\"auto\">\u00a0(currently blinded) had a combined sensitivity to 90%. These findings suggest that parallel use of antibody assays may be useful for diagnosing SARS-CoV-2 in low resource settings.<\/span><span data-contrast=\"auto\">\u00a0<\/span><i><span data-contrast=\"auto\">[EDITORIAL NOTE: The specificity of the combined test, assuming that a sample is judged positive if either test is positive, will be less than or equal to the specificity of the least specific of the two individual tests]<\/span><\/i><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Kushemererwa\u00a0et al. (June 29, 2020). Combination of Antibody Based Rapid Diagnostic Tests Used in an Algorithm May Improve Their Performance in SARS CoV-2 Diagnosis. Pre-print downloaded June 30 from\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.1101\/2020.06.26.20140806\"><span data-contrast=\"none\">https:\/\/doi.org\/10.1101\/2020.06.26.20140806<\/span><\/a><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>[pre-print, not peer-reviewed]\u00a0Kushemererwa\u00a0et al. evaluated 13 rapid-diagnostic IgG\/IgM antibody tests for SARS-CoV-2\u00a0to inform the\u00a0development of a diagnostic algorithm\u00a0for use in settings where PCR-based\u00a0diagnostics\u00a0are not available.\u00a0PCR&#8211;positive samples used for the evaluation were collected 0-28 days after the patient was confirmed positive.\u00a0They\u00a0evaluated 78 possible combinations of 2 assays to be used in parallel.\u00a0\u00a0 The individual sensitivities of&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/06\/30\/combination-of-antibody-based-rapid-diagnostic-tests-used-in-an-algorithm-may-improve-their-performance-in-sars-cov-2-diagnosis\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[],"topic":[19],"class_list":["post-7882","post","type-post","status-publish","format-standard","hentry","category-article-summary","topic-testing-and-treatment"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/7882","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=7882"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/7882\/revisions"}],"predecessor-version":[{"id":7883,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/7882\/revisions\/7883"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=7882"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=7882"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=7882"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=7882"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}