{"id":7949,"date":"2020-07-06T20:16:30","date_gmt":"2020-07-07T03:16:30","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=7949"},"modified":"2021-03-29T20:17:11","modified_gmt":"2021-03-30T03:17:11","slug":"treatment-with-ace-inhibitors-or-arbs-and-risk-of-severe-lethal-covid-19-a-meta-analysis","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/07\/06\/treatment-with-ace-inhibitors-or-arbs-and-risk-of-severe-lethal-covid-19-a-meta-analysis\/","title":{"rendered":"Treatment with ACE Inhibitors or ARBs and Risk of Severe\/Lethal COVID-19: A Meta-Analysis"},"content":{"rendered":"<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"34\" data-aria-posinset=\"2019\" data-aria-level=\"1\"><span data-contrast=\"auto\">Flacco et al.<\/span><span data-contrast=\"auto\">\u00a0conducted a meta-analysis\u00a0<\/span><span data-contrast=\"auto\">(<\/span><span data-contrast=\"auto\">10 studies including 9,890<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">subjects<\/span><span data-contrast=\"auto\">)<\/span><span data-contrast=\"auto\">\u00a0to estimate the association between hypertensive medication and COVID-19 outcomes. Results showed that<\/span><span data-contrast=\"auto\">,<\/span><span data-contrast=\"auto\">\u00a0compared to untreated subjects, treatment with ACE inhibitors or\u00a0<\/span><span data-contrast=\"auto\">angiotensin receptor blockers (ARBs)\u00a0<\/span><span data-contrast=\"auto\">was not associated with the risk of severe or lethal COVID-19 (<\/span><span data-contrast=\"auto\">OR<\/span><span data-contrast=\"auto\">=<\/span><span data-contrast=\"auto\">0.90, 95%CI 0.65-1.26 for ACE inhibitors;\u00a0<\/span><span data-contrast=\"auto\">OR<\/span><span data-contrast=\"auto\">=<\/span><span data-contrast=\"auto\">0.92, 95%CI 0.75-1.12 for ARBs). Treatment with both drugs was not associated with risk of death<\/span><span data-contrast=\"auto\">\u00a0from COVID-19<\/span><span data-contrast=\"auto\">\u00a0(<\/span><span data-contrast=\"auto\">OR<\/span><span data-contrast=\"auto\">=<\/span><span data-contrast=\"auto\">0.88, 95%CI 0.68-1.14).<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"34\" data-aria-posinset=\"2019\" data-aria-level=\"1\"><span data-contrast=\"auto\">The authors<\/span><span data-contrast=\"auto\">\u00a0recommend\u00a0<\/span><span data-contrast=\"auto\">the\u00a0<\/span><span data-contrast=\"auto\">continu<\/span><span data-contrast=\"auto\">ation of<\/span><span data-contrast=\"auto\">\u00a0ARBs or ACE inhibitors for all patients, unless otherwise advised by their physicians.<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Flacco et al. (July 1, 2020). Treatment with ACE Inhibitors or ARBs and Risk of Severe\/Lethal COVID-19: A Meta-Analysis. Heart.\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.1136\/heartjnl-2020-317336\"><span data-contrast=\"none\">https:\/\/doi.org\/10.1136\/heartjnl-2020-317336<\/span><\/a><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Flacco et al.\u00a0conducted a meta-analysis\u00a0(10 studies including 9,890\u00a0subjects)\u00a0to estimate the association between hypertensive medication and COVID-19 outcomes. Results showed that,\u00a0compared to untreated subjects, treatment with ACE inhibitors or\u00a0angiotensin receptor blockers (ARBs)\u00a0was not associated with the risk of severe or lethal COVID-19 (OR=0.90, 95%CI 0.65-1.26 for ACE inhibitors;\u00a0OR=0.92, 95%CI 0.75-1.12 for ARBs). Treatment with both drugs&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/07\/06\/treatment-with-ace-inhibitors-or-arbs-and-risk-of-severe-lethal-covid-19-a-meta-analysis\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[],"topic":[19],"class_list":["post-7949","post","type-post","status-publish","format-standard","hentry","category-article-summary","topic-testing-and-treatment"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/7949","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=7949"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/7949\/revisions"}],"predecessor-version":[{"id":7950,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/7949\/revisions\/7950"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=7949"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=7949"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=7949"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=7949"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}