{"id":7951,"date":"2020-07-06T20:17:22","date_gmt":"2020-07-07T03:17:22","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=7951"},"modified":"2021-03-29T20:18:05","modified_gmt":"2021-03-30T03:18:05","slug":"diagnostic-accuracy-of-serological-tests-for-covid-19-systematic-review-and-meta-analysis","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/07\/06\/diagnostic-accuracy-of-serological-tests-for-covid-19-systematic-review-and-meta-analysis\/","title":{"rendered":"Diagnostic Accuracy of Serological Tests for Covid-19: Systematic Review and Meta-Analysis"},"content":{"rendered":"<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"34\" data-aria-posinset=\"2019\" data-aria-level=\"1\"><span data-contrast=\"auto\">The diagnostic accuracy of serological tests for\u00a0<\/span><span data-contrast=\"auto\">SARS-CoV-2 antibodies<\/span><span data-contrast=\"auto\">\u00a0was reviewed by\u00a0<\/span><span data-contrast=\"auto\">Lisboa Bastos et al.<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">based on<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">40 studies<\/span><span data-contrast=\"auto\">\u00a0and\u00a0<\/span><span data-contrast=\"auto\">49 bias assessments.\u00a0<\/span><span data-contrast=\"auto\">They found\u00a0<\/span><span data-contrast=\"auto\">a\u00a0<\/span><span data-contrast=\"auto\">h<\/span><span data-contrast=\"auto\">igh risk of patient selection bias in 98% (48\/49) of assessments and high or unclear risk of bias\u00a0<\/span><span data-contrast=\"auto\">regarding\u00a0<\/span><span data-contrast=\"auto\">performance or interpretation of the serological test in 73% (36\/49).\u00a0<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"34\" data-aria-posinset=\"2019\" data-aria-level=\"1\"><span data-contrast=\"auto\">The pooled sensitivity of ELISAs was 84.3% (95%CI 75.6-90.9%), of lateral flow immunoassays<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">was 66.0% (49.3-79.3%), and of chemiluminescent immunoassays<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">was 97.8% (46.2-100%). Sensitivity was higher at least three weeks after symptom onset (range 69.9-98.9%) compared with within the first week (range 13.4-50.3%). Among\u00a0<\/span><span data-contrast=\"auto\">lateral flow assays<\/span><span data-contrast=\"auto\">, pooled sensitivity of commercial kits (65.0%, 49.0-78.2%) was lower than that of non-commercial tests (88.2%, 83.6-91.3%).<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">Pooled specificities ranged from 96.6% to 99.7%<\/span><span data-contrast=\"auto\">, with a pooled specificity for lateral flow tests of 96.6-97.6%<\/span><span data-contrast=\"auto\">.<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"34\" data-aria-posinset=\"2019\" data-aria-level=\"1\"><span data-contrast=\"auto\">The authors\u00a0<\/span><span data-contrast=\"auto\">raised concerns about\u00a0<\/span><span data-contrast=\"auto\">further<\/span><span data-contrast=\"auto\">\u00a0use of existing point-of-care serological tests<\/span><span data-contrast=\"auto\">\u00a0based on<\/span><span data-contrast=\"auto\">\u00a0their limited sensitivity<\/span><span data-contrast=\"auto\">.<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Lisboa Bastos et al. (July 1, 2020). Diagnostic Accuracy of Serological Tests for Covid-19: Systematic Review and Meta-Analysis. BMJ (Clinical Research Ed.).\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.1136\/bmj.m2516\"><span data-contrast=\"none\">https:\/\/doi.org\/10.1136\/bmj.m2516<\/span><\/a><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>The diagnostic accuracy of serological tests for\u00a0SARS-CoV-2 antibodies\u00a0was reviewed by\u00a0Lisboa Bastos et al.\u00a0based on\u00a040 studies\u00a0and\u00a049 bias assessments.\u00a0They found\u00a0a\u00a0high risk of patient selection bias in 98% (48\/49) of assessments and high or unclear risk of bias\u00a0regarding\u00a0performance or interpretation of the serological test in 73% (36\/49).\u00a0\u00a0 The pooled sensitivity of ELISAs was 84.3% (95%CI 75.6-90.9%), of lateral&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/07\/06\/diagnostic-accuracy-of-serological-tests-for-covid-19-systematic-review-and-meta-analysis\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[],"topic":[19],"class_list":["post-7951","post","type-post","status-publish","format-standard","hentry","category-article-summary","topic-testing-and-treatment"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/7951","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=7951"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/7951\/revisions"}],"predecessor-version":[{"id":7952,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/7951\/revisions\/7952"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=7951"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=7951"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=7951"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=7951"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}