{"id":8035,"date":"2020-07-08T08:38:33","date_gmt":"2020-07-08T15:38:33","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=8035"},"modified":"2021-03-31T08:39:16","modified_gmt":"2021-03-31T15:39:16","slug":"an-evaluation-of-covid-19-serological-assays-informs-future-diagnostics-and-exposure-assessment","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/07\/08\/an-evaluation-of-covid-19-serological-assays-informs-future-diagnostics-and-exposure-assessment\/","title":{"rendered":"An Evaluation of COVID-19 Serological Assays Informs Future Diagnostics and Exposure Assessment"},"content":{"rendered":"<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"34\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"auto\">In a comparison of eight SARS-CoV-2 serological assays,\u00a0GeurtsvanKessel\u00a0et. al found that the\u00a0Wantai\u00a0ELISA for detecting total Ig and IgM antibodies (Beijing\u00a0Wantai\u00a0Biological Pharmacy Enterprise Co., Ltd., China) had the best overall performance. The\u00a0Wantai\u00a0ELISA had a specificity of 99% and sensitivities of 99% for IgG and 90% IgM\u00a0antibodies, and\u00a0was able to detect functional antibodies in different stages and severity of disease.<\/span><span data-contrast=\"auto\">\u00a0<\/span><i><span data-contrast=\"auto\">[EDITORIAL NOTE: Assessment of sensitivity was based on samples confirmed to have SARS-CoV-2 antibodies by PRNT50.\u00a0Therefore\u00a0these\u00a0<\/span><\/i><i><span data-contrast=\"auto\">should be considered\u00a0<\/span><\/i><i><span data-contrast=\"auto\">estimates\u00a0<\/span><\/i><i><span data-contrast=\"auto\">of\u00a0<\/span><\/i><i><span data-contrast=\"auto\">the analytic sensitivity rather than the clinical\u00a0<\/span><\/i><i><span data-contrast=\"auto\">sensitivity<\/span><\/i><i><span data-contrast=\"auto\">]<\/span><\/i><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">GeurtsvanKessel\u00a0et al. (July 4, 2020). An Evaluation of COVID-19 Serological Assays Informs Future Diagnostics and Exposure Assessment. Nature Communications.\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.1038\/s41467-020-17317-y\"><span data-contrast=\"none\">https:\/\/doi.org\/10.1038\/s41467-020-17317-y<\/span><\/a><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>In a comparison of eight SARS-CoV-2 serological assays,\u00a0GeurtsvanKessel\u00a0et. al found that the\u00a0Wantai\u00a0ELISA for detecting total Ig and IgM antibodies (Beijing\u00a0Wantai\u00a0Biological Pharmacy Enterprise Co., Ltd., China) had the best overall performance. The\u00a0Wantai\u00a0ELISA had a specificity of 99% and sensitivities of 99% for IgG and 90% IgM\u00a0antibodies, and\u00a0was able to detect functional antibodies in different stages and&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/07\/08\/an-evaluation-of-covid-19-serological-assays-informs-future-diagnostics-and-exposure-assessment\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[],"topic":[19],"class_list":["post-8035","post","type-post","status-publish","format-standard","hentry","category-article-summary","topic-testing-and-treatment"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/8035","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=8035"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/8035\/revisions"}],"predecessor-version":[{"id":8036,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/8035\/revisions\/8036"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=8035"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=8035"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=8035"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=8035"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}