{"id":8078,"date":"2020-07-09T09:05:19","date_gmt":"2020-07-09T16:05:19","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=8078"},"modified":"2021-03-31T09:05:59","modified_gmt":"2021-03-31T16:05:59","slug":"systematic-review-with-meta-analysis-liver-manifestations-and-outcomes-in-covid-19","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/07\/09\/systematic-review-with-meta-analysis-liver-manifestations-and-outcomes-in-covid-19\/","title":{"rendered":"Systematic Review with Meta-Analysis: Liver Manifestations and Outcomes in COVID-19"},"content":{"rendered":"<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"34\" data-aria-posinset=\"2019\" data-aria-level=\"1\"><span data-contrast=\"auto\">A<\/span><span data-contrast=\"auto\">\u00a0systematic review and meta-analysis\u00a0<\/span><span data-contrast=\"auto\">(<\/span><span data-contrast=\"auto\">107 studies, 20,874 COVID-19 patients<\/span><span data-contrast=\"auto\">) shows that<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">the severity of elevated liver chemistries is associated with the outcome of COVID-19; however, the presenc<\/span><span data-contrast=\"auto\">e of chronic liver disease<\/span><span data-contrast=\"auto\">\u00a0does not alter the outcome of COVID-19. COVID-19 patients with elevated liver chemistries had increased risk of mortality (OR=3.46; 95%CI 2.42-4.95) and severe disease (OR=2.87; 95%CI 2.29-3.6) compared to patients without elevated liver chemistries.\u00a0<\/span><span data-contrast=\"auto\">C<\/span><span data-contrast=\"auto\">hronic liver disease\u00a0<\/span><span data-contrast=\"auto\">was not associated with\u00a0<\/span><span data-contrast=\"auto\">developing severe COVID-19<\/span><span data-contrast=\"auto\">\u00a0(OR=<\/span><span data-contrast=\"auto\">0.81 (95% CI 0.31-2.09).<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><\/i><i><span data-contrast=\"none\">Kulkarni et al. (July\u00a0<\/span><\/i><i><span data-contrast=\"none\">8,\u00a0<\/span><\/i><i><span data-contrast=\"none\">2020). Systematic Review with Meta-Analysis: Liver Manifestations and Outcomes in COVID-19. Alimentary Pharmacology &amp; Therapeutics.\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.1111\/apt.15916\"><span data-contrast=\"none\">https:\/\/doi.org\/10.1111\/apt.15916<\/span><\/a><i><span data-contrast=\"none\">\u00a0<\/span><\/i><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A\u00a0systematic review and meta-analysis\u00a0(107 studies, 20,874 COVID-19 patients) shows that\u00a0the severity of elevated liver chemistries is associated with the outcome of COVID-19; however, the presence of chronic liver disease\u00a0does not alter the outcome of COVID-19. COVID-19 patients with elevated liver chemistries had increased risk of mortality (OR=3.46; 95%CI 2.42-4.95) and severe disease (OR=2.87; 95%CI 2.29-3.6)&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/07\/09\/systematic-review-with-meta-analysis-liver-manifestations-and-outcomes-in-covid-19\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_members_access_role":[],"_members_access_error":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[],"topic":[20],"class_list":["post-8078","post","type-post","status-publish","format-standard","hentry","category-article-summary","topic-clinical-characteristics-and-health-care-setting"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/8078","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=8078"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/8078\/revisions"}],"predecessor-version":[{"id":8079,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/8078\/revisions\/8079"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=8078"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=8078"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=8078"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=8078"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}