{"id":8229,"date":"2020-07-15T11:18:34","date_gmt":"2020-07-15T18:18:34","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=8229"},"modified":"2021-04-01T11:34:36","modified_gmt":"2021-04-01T18:34:36","slug":"covid-19-literature-situation-report-july-15-2020","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/07\/15\/covid-19-literature-situation-report-july-15-2020\/","title":{"rendered":"COVID-19 Literature Situation Report July 15, 2020"},"content":{"rendered":"<p>The scientific literature on COVID-19 is rapidly evolving and these articles were selected for review based on their relevance to Washington State decision making around COVID-19 response efforts. Included in these Lit Reps are some manuscripts that have been made available online as pre-prints but have not yet undergone peer review. Please be aware of this when reviewing articles included in the Lit Reps.<\/p>\n<h2>Key Takeaways<\/h2>\n<ul>\n<li><b><span data-contrast=\"auto\">A<\/span><\/b><b><span data-contrast=\"auto\">\u00a0phase 1, dose-escalation, open-label trial of the candidate vaccine mRNA-1273 among 45 healthy adults<\/span><\/b><b><span data-contrast=\"auto\">\u00a0found that all participants had serum neutralizing antibody activity after the second vaccination<\/span><\/b><b><span data-contrast=\"auto\">. No trial-limiting safety concerns were identified.<\/span><\/b><span data-contrast=\"auto\">\u00a0<\/span><a href=\"https:\/\/doi.org\/10.1056\/NEJMoa2022483\"><span data-contrast=\"none\">More<\/span><\/a><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0d8\" data-font=\"Wingdings\" data-listid=\"1\" data-aria-posinset=\"1\" data-aria-level=\"1\"><b><span data-contrast=\"auto\">Self-reported contact surveys and wearable proximity sensors were highly correlated\u00a0<\/span><\/b><b><span data-contrast=\"auto\">method<\/span><\/b><b><span data-contrast=\"auto\">s<\/span><\/b><b><span data-contrast=\"auto\">\u00a0for<\/span><\/b><b><span data-contrast=\"auto\">\u00a0capturing\u00a0<\/span><\/b><b><span data-contrast=\"auto\">person-to-person\u00a0<\/span><\/b><b><span data-contrast=\"auto\">contact<\/span><\/b><b><span data-contrast=\"auto\">\u00a0patterns<\/span><\/b><b><span data-contrast=\"auto\">\u00a0relevant to respiratory virus transmission among 730 schoolchildren in the Pittsburgh metropolitan area.<\/span><\/b><span data-contrast=\"auto\">\u00a0<\/span><a href=\"https:\/\/doi.org\/10.1101\/2020.07.12.20151696\"><span data-contrast=\"none\">More<\/span><\/a><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0d8\" data-font=\"Wingdings\" data-listid=\"1\" data-aria-posinset=\"2\" data-aria-level=\"1\"><b><span data-contrast=\"auto\">Updated\u00a0<\/span><\/b><b><span data-contrast=\"auto\">COVID-19\u00a0<\/span><\/b><b><span data-contrast=\"auto\">forecasts from the Ins<\/span><\/b><b><span data-contrast=\"auto\">t<\/span><\/b><b><span data-contrast=\"auto\">itute for Health Metrics and Evaluation<\/span><\/b><b><span data-contrast=\"auto\">\u00a0<\/span><\/b><b><span data-contrast=\"auto\">estimated that the\u00a0<\/span><\/b><b><span data-contrast=\"auto\">cumulative mortality\u00a0<\/span><\/b><b><span data-contrast=\"auto\">in<\/span><\/b><b><span data-contrast=\"auto\">\u00a0the US could reach 430,494 by\u00a0<\/span><\/b><b><span data-contrast=\"auto\">the end of<\/span><\/b><b><span data-contrast=\"auto\">\u00a02020.\u00a0<\/span><\/b><b><span data-contrast=\"auto\">Their model indicates that u<\/span><\/b><b><span data-contrast=\"auto\">niversal mask use may\u00a0<\/span><\/b><b><span data-contrast=\"auto\">prevent nearly<\/span><\/b><b><span data-contrast=\"auto\">\u00a025%<\/span><\/b><b><span data-contrast=\"auto\">\u00a0of the estimated<\/span><\/b><b><span data-contrast=\"auto\">\u00a0<\/span><\/b><b><span data-contrast=\"auto\">deaths<\/span><\/b><b><span data-contrast=\"auto\">.<\/span><\/b><span data-contrast=\"auto\">\u00a0<\/span><a href=\"https:\/\/doi.org\/10.1101\/2020.07.12.20151191\"><span data-contrast=\"none\">More<\/span><\/a><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0d8\" data-font=\"Wingdings\" data-listid=\"1\" data-aria-posinset=\"3\" data-aria-level=\"1\"><b><span data-contrast=\"auto\">A neonate born to a mother infected in the\u00a0<\/span><\/b><b><span data-contrast=\"auto\">third<\/span><\/b><b><span data-contrast=\"auto\">\u00a0<\/span><\/b><b><span data-contrast=\"auto\">trimester\u00a0<\/span><\/b><b><span data-contrast=\"auto\">was confirmed\u00a0<\/span><\/b><b><span data-contrast=\"auto\">to have<\/span><\/b><b><span data-contrast=\"auto\">\u00a0transplacental transmission of SARS-CoV-2.\u00a0<\/span><\/b><a href=\"https:\/\/doi.org\/10.1038\/s41467-020-17436-6\"><span data-contrast=\"none\">More<\/span><\/a><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<div id=\"uw-accordion-shortcode\">\n<h3>Article Summaries<\/h3>\n<div class=\"js-accordion\" data-accordion-prefix-classes=\"uw-accordion-shortcode\">\n<div class=\"js-accordion__panel\" >\n<h2 class=\"js-accordion__header\"><span class=\"TextRun SCXW243650001 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW243650001 BCX0\" data-ccp-parastyle=\"heading 2\">Non-Pharmaceutical Interventions<\/span><\/span><\/h2>\n<div class=\"su-posts su-posts-default-loop\">\n<div id=\"su-post-8231\" class=\"su-post\">\n<h5 class=\"su-post-title\">Age-Specific Social Mixing of School-Aged Children in\u00a0a\u00a0US Setting Using Proximity Detecting Sensors and Contact Surveys<\/h5>\n<p>\t\t\t\t<!-- \n\n\n\n\n\n\n\n\n\n\n\n<div class=\"su-post-meta\">\n\t\t\t\t\t: \t\t\t\t<\/div>\n\n\n\n\n\n\n\n\n\n\n\n --><\/p>\n<div class=\"su-post-excerpt\">\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"34\" data-aria-posinset=\"2019\" data-aria-level=\"1\"><i><span data-contrast=\"none\">[Preprint, not peer-reviewed]\u00a0<\/span><\/i><span data-contrast=\"auto\">Grantz et al.\u00a0<\/span><span data-contrast=\"auto\">compared data from self-reported contact surveys and wearable proximity sensors from 730 schoolchildren in the Pittsburgh metropolitan area.\u00a0<\/span><span data-contrast=\"auto\">T<\/span><span data-contrast=\"auto\">he two methods produced highly correlated data on age-specific mixing patterns relevant to the dynamics of respiratory virus transmission<\/span><span data-contrast=\"auto\">.\u00a0<\/span><span data-contrast=\"auto\">The results from the methods differed in that p<\/span><span data-contrast=\"auto\">articipants reported<\/span><span data-contrast=\"auto\">\u00a0fewer but longer contacts in surveys relative to the generally short proximal interactions captured by wearable sensors.<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Grantz et al. (July 14, 2020). Age-Specific Social Mixing of School-Aged Children in\u00a0a\u00a0US Setting Using Proximity Detecting Sensors and Contact Surveys. Pre-print\u00a0downloaded July 15 from\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.1101\/2020.07.12.20151696\"><span data-contrast=\"none\">https:\/\/doi.org\/10.1101\/2020.07.12.20151696<\/span><\/a><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<\/p>\n<\/div>\n<p>\t\t\t\t\t\t\t\t\t<!-- <a href=\"\" class=\"su-post-comments-link\"><\/a> --><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"js-accordion__panel\" >\n<h2 class=\"js-accordion__header\"><span class=\"TextRun SCXW70641427 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW70641427 BCX0\" data-ccp-parastyle=\"heading 2\">Transmission<\/span><\/span><\/h2>\n<div class=\"su-posts su-posts-default-loop\">\n<div id=\"su-post-8233\" class=\"su-post\">\n<h5 class=\"su-post-title\">Transplacental Transmission of SARS-CoV-2 Infection<\/h5>\n<p>\t\t\t\t<!-- \n\n\n\n\n\n\n\n\n\n\n\n<div class=\"su-post-meta\">\n\t\t\t\t\t: \t\t\t\t<\/div>\n\n\n\n\n\n\n\n\n\n\n\n --><\/p>\n<div class=\"su-post-excerpt\">\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"34\" data-aria-posinset=\"2019\" data-aria-level=\"1\"><span data-contrast=\"auto\">Vivanti\u00a0et al.\u00a0<\/span><span data-contrast=\"auto\">demonstrated a transplacental transmission of SARS-CoV-2 in a neonate born to a mother infected in the\u00a0<\/span><span data-contrast=\"auto\">third\u00a0<\/span><span data-contrast=\"auto\">trimester\u00a0<\/span><span data-contrast=\"auto\">and delivered\u00a0<\/span><span data-contrast=\"auto\">at\u00a0the\u00a0<\/span><span data-contrast=\"auto\">Paris\u00a0Saclay\u00a0University Hospitals<\/span><span data-contrast=\"auto\">.\u00a0<\/span><span data-contrast=\"auto\">RT-PCR\u00a0<\/span><span data-contrast=\"auto\">testing\u00a0<\/span><span data-contrast=\"auto\">for SARS-CoV-2<\/span><span data-contrast=\"auto\">\u00a0w<\/span><span data-contrast=\"auto\">as<\/span><span data-contrast=\"auto\">\u00a0positive from multiple sites from the neonate, including blood, b<\/span><span data-contrast=\"auto\">ronchoalveolar lavage fluid,\u00a0<\/span><span data-contrast=\"auto\">nasopharyngeal and<\/span><span data-contrast=\"auto\">\u00a0rectal swabs, and placental samples.\u00a0<\/span><span data-contrast=\"auto\">The neonate\u00a0presented\u00a0with neurological manifestations,\u00a0similar to\u00a0those described in adult patients<\/span><span data-contrast=\"auto\">.<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Vivanti\u00a0et al. (Dec 14, 2020). Transplacental Transmission of SARS-CoV-2 Infection. Nature Communications.\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.1038\/s41467-020-17436-6\"><span data-contrast=\"none\">https:\/\/doi.org\/10.1038\/s41467-020-17436-6<\/span><\/a><i><span data-contrast=\"none\">\u00a0<\/span><\/i><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<\/p>\n<\/div>\n<p>\t\t\t\t\t\t\t\t\t<!-- <a href=\"\" class=\"su-post-comments-link\"><\/a> --><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"js-accordion__panel\" >\n<h2 class=\"js-accordion__header\"><span class=\"TextRun SCXW117094610 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW117094610 BCX0\" data-ccp-parastyle=\"heading 2\">Testing and Treatment<\/span><\/span><\/h2>\n<div class=\"su-posts su-posts-default-loop\">\n<div id=\"su-post-8241\" class=\"su-post\">\n<h5 class=\"su-post-title\">SARS-CoV-2 Antibody Responses Do Not Predict COVID-19 Disease Severity<\/h5>\n<p>\t\t\t\t<!-- \n\n\n\n\n\n\n\n\n\n\n\n<div class=\"su-post-meta\">\n\t\t\t\t\t: \t\t\t\t<\/div>\n\n\n\n\n\n\n\n\n\n\n\n --><\/p>\n<div class=\"su-post-excerpt\">\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"34\" data-aria-posinset=\"2019\" data-aria-level=\"1\"><span data-contrast=\"auto\">Based on a sample of 172\u00a0<\/span><span data-contrast=\"auto\">suspected cases of SARS-CoV-2<\/span><span data-contrast=\"auto\">\u00a0and 795 negative plasma samples, IgG antibody testing had a\u00a0<\/span><span data-contrast=\"auto\">100% specificity (0\/795)\u00a0and\u00a0<\/span><span data-contrast=\"auto\">IgG tests were positive for\u00a0<\/span><span data-contrast=\"auto\">83%\u00a0<\/span><span data-contrast=\"auto\">of suspected cases\u00a0<\/span><span data-contrast=\"auto\">among samples collected more than 14 days from symptom onset.\u00a0<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"34\" data-aria-posinset=\"2019\" data-aria-level=\"1\"><span data-contrast=\"auto\">There was no<\/span><span data-contrast=\"auto\">\u00a0association\u00a0<\/span><span data-contrast=\"auto\">between the level of IgG an<\/span><span data-contrast=\"auto\">d IgM reactivity and mi<\/span><span data-contrast=\"auto\">ld<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">versus\u00a0<\/span><span data-contrast=\"auto\">severe disease course.<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Phipps et al. (July 15, 2020). SARS-CoV-2 Antibody Responses Do Not Predict COVID-19 Disease Severity. American Journal of Clinical Pathology.\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.1093\/ajcp\/aqaa123\"><span data-contrast=\"none\">https:\/\/doi.org\/10.1093\/ajcp\/aqaa123<\/span><\/a><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<\/p>\n<\/div>\n<p>\t\t\t\t\t\t\t\t\t<!-- <a href=\"\" class=\"su-post-comments-link\"><\/a> --><\/p>\n<\/div>\n<div id=\"su-post-8239\" class=\"su-post\">\n<h5 class=\"su-post-title\">At What Times during Infection Is SARS-CoV-2 Detectable and No Longer Detectable Using RT-PCR Based Tests A Systematic Review of Individual Participant Data<\/h5>\n<p>\t\t\t\t<!-- \n\n\n\n\n\n\n\n\n\n\n\n<div class=\"su-post-meta\">\n\t\t\t\t\t: \t\t\t\t<\/div>\n\n\n\n\n\n\n\n\n\n\n\n --><\/p>\n<div class=\"su-post-excerpt\">\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"34\" data-aria-posinset=\"2019\" data-aria-level=\"1\"><i><span data-contrast=\"none\">[Preprint, not peer-reviewed]\u00a0<\/span><\/i><span data-contrast=\"auto\">A systematic review\u00a0<\/span><span data-contrast=\"auto\">(<\/span><span data-contrast=\"auto\">32 studies\u00a0<\/span><span data-contrast=\"auto\">with<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">1,023 SARS-CoV-2 infected patients<\/span><span data-contrast=\"auto\">)<\/span><span data-contrast=\"auto\">\u00a0showed the highest percentage of detection\u00a0<\/span><span data-contrast=\"auto\">of SARS-CoV-2 by RT-PCR\u00a0<\/span><span data-contrast=\"auto\">was from nasopharyngeal sampling between 0 to 4 days post-symptom onset at 89% (95%CI 83<\/span><span data-contrast=\"auto\">%<\/span><span data-contrast=\"auto\">-93<\/span><span data-contrast=\"auto\">%<\/span><span data-contrast=\"auto\">). The percentage dropped to 54% (95%CI 47<\/span><span data-contrast=\"auto\">%<\/span><span data-contrast=\"auto\">-61<\/span><span data-contrast=\"auto\">%<\/span><span data-contrast=\"auto\">) after 10 to 14 days.\u00a0<\/span><span data-contrast=\"auto\">Up to 30% of participants with\u00a0<\/span><span data-contrast=\"auto\">SARS-CoV-2<\/span><span data-contrast=\"auto\">\u00a0detected in respiratory samples did not have detectable fecal samples<\/span><span data-contrast=\"auto\">.\u00a0<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Mallett et al. (July 14, 2020). At What Times during Infection Is SARS-CoV-2 Detectable and No Longer Detectable Using RT-PCR Based Tests A Systematic Review of Individual Participant Data. Pre-print\u00a0downloaded July 15 from\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.1101\/2020.07.13.20152793\"><span data-contrast=\"none\">https:\/\/doi.org\/10.1101\/2020.07.13.20152793<\/span><\/a><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<\/p>\n<\/div>\n<p>\t\t\t\t\t\t\t\t\t<!-- <a href=\"\" class=\"su-post-comments-link\"><\/a> --><\/p>\n<\/div>\n<div id=\"su-post-8237\" class=\"su-post\">\n<h5 class=\"su-post-title\">Significantly Improved COVID-19 Outcomes in Countries with Higher BCG Vaccination Coverage:\u00a0A Multivariable\u00a0Analysis<\/h5>\n<p>\t\t\t\t<!-- \n\n\n\n\n\n\n\n\n\n\n\n<div class=\"su-post-meta\">\n\t\t\t\t\t: \t\t\t\t<\/div>\n\n\n\n\n\n\n\n\n\n\n\n --><\/p>\n<div class=\"su-post-excerpt\">\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"34\" data-aria-posinset=\"2019\" data-aria-level=\"1\"><span data-contrast=\"auto\">An ecological study conducted by\u00a0<\/span><span data-contrast=\"auto\">Klinger et al.\u00a0find\u00a0a strong negative correlation between the years of BCG administration and the deaths per million\u00a0<\/span><span data-contrast=\"auto\">from\u00a0<\/span><span data-contrast=\"auto\">COVID-19\u00a0<\/span><span data-contrast=\"auto\">based on<\/span><span data-contrast=\"auto\">\u00a0data from 55 countries. Countries with BCG immunization policies over the past 15 years have a significantly lower rate of\u00a0<\/span><span data-contrast=\"auto\">COVID-19 deaths\u00a0<\/span><span data-contrast=\"auto\">than countries with no BCG in last 15 years (p=0.0004).<\/span><span data-contrast=\"auto\">\u00a0<\/span><i><span data-contrast=\"auto\">[EDITORIAL NOTE: Results from ecological studies should be interpreted with caution due to unmeasured confounding between countries and may not reflect individual-level effects]<\/span><\/i><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Klinger et al. (July 11, 2020). Significantly Improved COVID-19 Outcomes in Countries with Higher BCG Vaccination Coverage:\u00a0A Multivariable\u00a0Analysis. Vaccines.\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.3390\/vaccines8030378\"><span data-contrast=\"none\">https:\/\/doi.org\/10.3390\/vaccines8030378<\/span><\/a><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<\/p>\n<\/div>\n<p>\t\t\t\t\t\t\t\t\t<!-- <a href=\"\" class=\"su-post-comments-link\"><\/a> --><\/p>\n<\/div>\n<div id=\"su-post-8235\" class=\"su-post\">\n<h5 class=\"su-post-title\">Detection of SARS-CoV-2 RNA in Commercial Passenger Aircraft and Cruise Ship Wastewater: A Surveillance Tool for Assessing the Presence of COVID-19 Infected Travelers<\/h5>\n<p>\t\t\t\t<!-- \n\n\n\n\n\n\n\n\n\n\n\n<div class=\"su-post-meta\">\n\t\t\t\t\t: \t\t\t\t<\/div>\n\n\n\n\n\n\n\n\n\n\n\n --><\/p>\n<div class=\"su-post-excerpt\">\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"34\" data-aria-posinset=\"2019\" data-aria-level=\"1\"><span data-contrast=\"auto\">D<\/span><span data-contrast=\"auto\">etection of SARS-CoV-2 RNA wa<\/span><span data-contrast=\"auto\">s<\/span><span data-contrast=\"auto\">\u00a0reported in 21 samples from aircraft and cruise ship wastewater<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">sanitation systems<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">(adsorption-extraction by electronegative membrane\u00a0<\/span><span data-contrast=\"auto\">[<\/span><span data-contrast=\"auto\">n=13<\/span><span data-contrast=\"auto\">]<\/span><span data-contrast=\"auto\">\u00a0and ultrafiltration by Amicon\u00a0<\/span><span data-contrast=\"auto\">[<\/span><span data-contrast=\"auto\">n=8<\/span><span data-contrast=\"auto\">]<\/span><span data-contrast=\"auto\">). Concentrations were near the limit of detection<\/span><span data-contrast=\"auto\">\u00a0for the assay<\/span><span data-contrast=\"auto\">.\u00a0<\/span><span data-contrast=\"auto\">Findings suggested the s<\/span><span data-contrast=\"auto\">urveillance of wastewater from large transport vessels with their own sanitation systems\u00a0<\/span><span data-contrast=\"auto\">could be\u00a0<\/span><span data-contrast=\"auto\">a complementary data source to prioritize clinical testing and contact tracing among disembarking passengers.<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Ahmed et al. (July 14, 2020). Detection of SARS-CoV-2 RNA in Commercial Passenger Aircraft and Cruise Ship Wastewater: A Surveillance Tool for Assessing the Presence of COVID-19 Infected Travelers. Journal of Travel Medicine.\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.1093\/jtm\/taaa116\"><span data-contrast=\"none\">https:\/\/doi.org\/10.1093\/jtm\/taaa116<\/span><\/a><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<\/p>\n<\/div>\n<p>\t\t\t\t\t\t\t\t\t<!-- <a href=\"\" class=\"su-post-comments-link\"><\/a> --><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"js-accordion__panel\" >\n<h2 class=\"js-accordion__header\"><span class=\"TextRun SCXW117094610 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW117094610 BCX0\" data-ccp-parastyle=\"heading 2\"><span class=\"TextRun SCXW89645626 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"none\"><span class=\"NormalTextRun ContextualSpellingAndGrammarErrorV2 SCXW89645626 BCX0\" data-ccp-parastyle=\"heading 2\">Vaccines<\/span><\/span><\/span><\/span><\/h2>\n<div class=\"su-posts su-posts-default-loop\">\n<div id=\"su-post-8243\" class=\"su-post\">\n<h5 class=\"su-post-title\">An MRNA Vaccine against SARS-CoV-2 \u2014 Preliminary Report<\/h5>\n<p>\t\t\t\t<!-- \n\n\n\n\n\n\n\n\n\n\n\n<div class=\"su-post-meta\">\n\t\t\t\t\t: \t\t\t\t<\/div>\n\n\n\n\n\n\n\n\n\n\n\n --><\/p>\n<div class=\"su-post-excerpt\">\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"34\" data-aria-posinset=\"2019\" data-aria-level=\"1\"><span data-contrast=\"auto\">The candidate vaccine mRNA-1273 was shown to induce antibody and T-cell\u00a0<\/span><span data-contrast=\"auto\">immune responses in all participants<\/span><span data-contrast=\"auto\">\u00a0(n=45).<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"34\" data-aria-posinset=\"2019\" data-aria-level=\"1\"><span data-contrast=\"auto\">Jackson et al.\u00a0<\/span><span data-contrast=\"auto\">conducted a phase 1, dose-escalation, open-label trial including 45 healthy adults, to test the candidate vaccine mRNA-1273 encoding the stabilized prefusion of SARS-CoV-2 spike protein. Participants received two vaccinations, 28 days apart\u00a0in\u00a0three dose groups.<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"34\" data-aria-posinset=\"2019\" data-aria-level=\"1\"><span data-contrast=\"auto\">After the first vaccination, antibody responses were higher among those who received the higher dose. After the second vaccination, the titers\u00a0increased\u00a0and all participants had\u00a0serumneutralizing\u00a0activity. No trial-limiting safety concerns were identified.\u00a0<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Jackson et al. (July 14, 2020). An MRNA Vaccine against SARS-CoV-2 \u2014 Preliminary Report. New England Journal of Medicine.\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.1056\/NEJMoa2022483\"><span data-contrast=\"none\">https:\/\/doi.org\/10.1056\/NEJMoa2022483<\/span><\/a><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<\/p>\n<\/div>\n<p>\t\t\t\t\t\t\t\t\t<!-- <a href=\"\" class=\"su-post-comments-link\"><\/a> --><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"js-accordion__panel\" >\n<h2 class=\"js-accordion__header\"><span class=\"TextRun SCXW22351167 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW22351167 BCX0\" data-ccp-parastyle=\"heading 2\">Clinical Characteristics<\/span><\/span><span class=\"TextRun SCXW22351167 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW22351167 BCX0\" data-ccp-parastyle=\"heading 2\"> and Health Care Setting<\/span><\/span><\/h2>\n<div class=\"su-posts su-posts-default-loop\">\n<div id=\"su-post-8247\" class=\"su-post\">\n<h5 class=\"su-post-title\">Association Between Universal Masking in a Health Care System and SARS-CoV-2 Positivity Among Health Care Workers<\/h5>\n<p>\t\t\t\t<!-- \n\n\n\n\n\n\n\n\n\n\n\n<div class=\"su-post-meta\">\n\t\t\t\t\t: \t\t\t\t<\/div>\n\n\n\n\n\n\n\n\n\n\n\n --><\/p>\n<div class=\"su-post-excerpt\">\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"44\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"auto\">A<\/span><span data-contrast=\"auto\">mong<\/span><span data-contrast=\"auto\">\u00a09,850\u00a0<\/span><span data-contrast=\"auto\">health care workers\u00a0<\/span><span data-contrast=\"auto\">Massachusetts between March 1 and April 30, 2020<\/span><span data-contrast=\"auto\">\u00a013<\/span><span data-contrast=\"auto\">%<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">were positive\u00a0<\/span><span data-contrast=\"auto\">for<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">SARS-CoV-2<\/span><span data-contrast=\"auto\">\u00a0by\u00a0<\/span><span data-contrast=\"auto\">RT-PCR<\/span><span data-contrast=\"auto\">.\u00a0<\/span><span data-contrast=\"auto\">Prior to implementation of<\/span><span data-contrast=\"auto\">\u00a0universal masking (March 1-24, 2020), the SARS-CoV-2 positivity rate increased exponentially from 0% to 21%, with<\/span><span data-contrast=\"auto\">\u00a0a<\/span><span data-contrast=\"auto\">\u00a0case doubling time of 3.6 days (95%CI 3.0-4.5 days).\u00a0<\/span><span data-contrast=\"auto\">After implementation of universal masking<\/span><span data-contrast=\"auto\">\u00a0(<\/span><span data-contrast=\"auto\">April 11-30, 2020),\u00a0<\/span><span data-contrast=\"auto\">the positivity rate decreased linearly from 14.<\/span><span data-contrast=\"auto\">7<\/span><span data-contrast=\"auto\">% to 11.<\/span><span data-contrast=\"auto\">5<\/span><span data-contrast=\"auto\">%, with a weighted mean decline of 0.49% per day.<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559685&quot;:360,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Wang et al. (July 14, 2020). Association Between Universal Masking in a Health Care System and SARS-CoV-2 Positivity Among Health Care Workers. JAMA.\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.1001\/jama.2020.12897\"><span data-contrast=\"none\">https:\/\/doi.org\/10.1001\/jama.2020.12897<\/span><\/a><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<\/p>\n<\/div>\n<p>\t\t\t\t\t\t\t\t\t<!-- <a href=\"\" class=\"su-post-comments-link\"><\/a> --><\/p>\n<\/div>\n<div id=\"su-post-8245\" class=\"su-post\">\n<h5 class=\"su-post-title\">Comparison of Mortality Risk in Patients with Cirrhosis and COVID-19 Compared with Patients with Cirrhosis Alone and COVID-19 Alone:\u00a0Multicentre\u00a0Matched Cohort<\/h5>\n<p>\t\t\t\t<!-- \n\n\n\n\n\n\n\n\n\n\n\n<div class=\"su-post-meta\">\n\t\t\t\t\t: \t\t\t\t<\/div>\n\n\n\n\n\n\n\n\n\n\n\n --><\/p>\n<div class=\"su-post-excerpt\">\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"34\" data-aria-posinset=\"2019\" data-aria-level=\"1\"><span data-contrast=\"auto\">A multicenter study in<\/span><span data-contrast=\"auto\">\u00a0the<\/span><span data-contrast=\"auto\">\u00a0US compared 37 inpatients with cirrhosis<\/span><span data-contrast=\"auto\">\u00a0and<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">COVID-19 to age<\/span><span data-contrast=\"auto\">&#8211; and<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">gender-matched patients with COVID-19 alone (n=108) or cirrhosis alone (n=127). Results showed that patients with cirrhosis<\/span><span data-contrast=\"auto\">\u00a0and<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">COVID-19 had\u00a0<\/span><span data-contrast=\"auto\">a non-significant<\/span><span data-contrast=\"auto\">l<\/span><span data-contrast=\"auto\">y higher mortality\u00a0<\/span><span data-contrast=\"auto\">compared\u00a0<\/span><span data-contrast=\"auto\">to\u00a0<\/span><span data-contrast=\"auto\">patients with cirrhosis alone<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">(30% vs 20%, p=0.16),\u00a0<\/span><span data-contrast=\"auto\">and significantly\u00a0<\/span><span data-contrast=\"auto\">higher\u00a0<\/span><span data-contrast=\"auto\">mortality\u00a0<\/span><span data-contrast=\"auto\">than patients with COVID-19 alone (30% vs 13%, p=0.03).\u00a0<\/span><span data-contrast=\"auto\">The elevated mortality among those with cirrhosis and COVID-19 may be at least partially attributable to a higher degree of co-morbidities, as measured by the\u00a0<\/span><span data-contrast=\"auto\">Charlson Comorbidity Index.<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Bajaj et al. (July 13, 2020). Comparison of Mortality Risk in Patients with Cirrhosis and COVID-19 Compared with Patients with Cirrhosis Alone and COVID-19 Alone:\u00a0Multicentre\u00a0Matched Cohort.\u00a0<\/span><\/i><span data-contrast=\"auto\">Gut.\u00a0<\/span><a href=\"https:\/\/doi.org\/10.1136\/gutjnl-2020-322118\"><span data-contrast=\"none\">https:\/\/doi.org\/10.1136\/gutjnl-2020-322118<\/span><\/a><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<\/p>\n<\/div>\n<p>\t\t\t\t\t\t\t\t\t<!-- <a href=\"\" class=\"su-post-comments-link\"><\/a> --><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"js-accordion__panel\" >\n<h2 class=\"js-accordion__header\"><span class=\"TextRun SCXW209496532 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW209496532 BCX0\" data-ccp-parastyle=\"heading 2\">Mental Health and Personal Impact<\/h2>\n<p><\/span><\/span><\/p>\n<div class=\"su-posts su-posts-default-loop\">\n<div id=\"su-post-8249\" class=\"su-post\">\n<h5 class=\"su-post-title\">Posttraumatic Stress Symptoms and Associated Comorbidity During the COVID\u201019 Pandemic in Ireland: A Population\u2010Based Study<\/h5>\n<p>\t\t\t\t<!-- \n\n\n\n\n\n\n\n\n\n\n\n<div class=\"su-post-meta\">\n\t\t\t\t\t: \t\t\t\t<\/div>\n\n\n\n\n\n\n\n\n\n\n\n --><\/p>\n<div class=\"su-post-excerpt\">\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"34\" data-aria-posinset=\"2019\" data-aria-level=\"1\"><span data-contrast=\"auto\">In a nationally representative sample of 1,041 adults from the general population of the Republic of Ireland, the rate of COVID-19-related posttraumatic stress disorder (PTSD) was 1<\/span><span data-contrast=\"auto\">8<\/span><span data-contrast=\"auto\">%<\/span><span data-contrast=\"auto\">. Of individuals<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">who screened positive for PTSD, 5<\/span><span data-contrast=\"auto\">4<\/span><span data-contrast=\"auto\">% met the criteria for depression<\/span><span data-contrast=\"auto\">,\u00a0<\/span><span data-contrast=\"auto\">50<\/span><span data-contrast=\"auto\">% for generalized anxiety disorder<\/span><span data-contrast=\"auto\">,\u00a0<\/span><span data-contrast=\"auto\">and 60% for either depression<\/span><span data-contrast=\"auto\">\u00a0or\u00a0<\/span><span data-contrast=\"auto\">anxiety<\/span><span data-contrast=\"auto\">. COVID-19-related PTSD was associated with younger age, male sex, living in a city, living with children,\u00a0<\/span><span data-contrast=\"auto\">and\u00a0<\/span><span data-contrast=\"auto\">moderate and high perceived risk of COVID-19 infection.<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Karatzias\u00a0et al. (July 13, 2020). Posttraumatic Stress Symptoms and Associated Comorbidity During the COVID\u201019 Pandemic in Ireland: A Population\u2010Based Study. Journal of Traumatic Stress.\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.1002\/jts.22565\"><span data-contrast=\"none\">https:\/\/doi.org\/10.1002\/jts.22565<\/span><\/a><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<\/p>\n<\/div>\n<p>\t\t\t\t\t\t\t\t\t<!-- <a href=\"\" class=\"su-post-comments-link\"><\/a> --><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"js-accordion__panel\" >\n<h2 class=\"js-accordion__header\"><span class=\"TextRun SCXW82890009 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW82890009 BCX0\" data-ccp-parastyle=\"heading 2\">Mode<\/span><\/span><span class=\"TextRun SCXW82890009 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW82890009 BCX0\" data-ccp-parastyle=\"heading 2\">ling and Prediction<\/span><\/span><\/h2>\n<div class=\"su-posts su-posts-default-loop\">\n<div id=\"su-post-8253\" class=\"su-post\">\n<h5 class=\"su-post-title\">Impact of COVID-19 on 2020 US Life Expectancy for the Black and Latino Populations<\/h5>\n<p>\t\t\t\t<!-- \n\n\n\n\n\n\n\n\n\n\n\n<div class=\"su-post-meta\">\n\t\t\t\t\t: \t\t\t\t<\/div>\n\n\n\n\n\n\n\n\n\n\n\n --><\/p>\n<div class=\"su-post-excerpt\">\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"34\" data-aria-posinset=\"2019\" data-aria-level=\"1\"><i><span data-contrast=\"none\">[Preprint, not peer-reviewed]\u00a0<\/span><\/i><span data-contrast=\"auto\">Andrasfay<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">and Goldman<\/span><span data-contrast=\"auto\">\u00a0used COVID-19 projections produced by the Institute for Health Metrics and Evaluation and estimated a reduction in life expectancy at birth due to COVID-19 of greater than 1.5 years for Black and Latino populations, which is one year larger than the reduction for whites. This would be a 30% increase (from 3.6 to 4.7 years) in the Black-white gap in life expectancy. The<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">survival advantage among Latinos would decline by 36%, equivalent to its magnitude in 2006.<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Andrasfay\u00a0and Goldman. (July 14, 2020). Impact of COVID-19 on 2020 US Life Expectancy for the Black and Latino Populations. Pre-print\u00a0downloaded July 15 from\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.1101\/2020.07.12.20148387\"><span data-contrast=\"none\">https:\/\/doi.org\/10.1101\/2020.07.12.20148387<\/span><\/a><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<\/p>\n<\/div>\n<p>\t\t\t\t\t\t\t\t\t<!-- <a href=\"\" class=\"su-post-comments-link\"><\/a> --><\/p>\n<\/div>\n<div id=\"su-post-8251\" class=\"su-post\">\n<h5 class=\"su-post-title\">COVID-19 Scenarios for the United States<\/h5>\n<p>\t\t\t\t<!-- \n\n\n\n\n\n\n\n\n\n\n\n<div class=\"su-post-meta\">\n\t\t\t\t\t: \t\t\t\t<\/div>\n\n\n\n\n\n\n\n\n\n\n\n --><\/p>\n<div class=\"su-post-excerpt\">\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"34\" data-aria-posinset=\"2019\" data-aria-level=\"1\"><i><span data-contrast=\"none\">[Preprint, not peer-reviewed]\u00a0<\/span><\/i><span data-contrast=\"auto\">The\u00a0<\/span><span data-contrast=\"auto\">Institute\u00a0<\/span><span data-contrast=\"auto\">for<\/span><span data-contrast=\"auto\">\u00a0Health Metrics and Evaluation (IHME)<\/span><span data-contrast=\"auto\">\u00a0team<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">used an SEIR model to estimate trajectories of SARS-CoV-2 infections and the impact of\u00a0<\/span><span data-contrast=\"auto\">non-pharmaceutical interventions<\/span><span data-contrast=\"auto\">\u00a0at the state level<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">from July\u00a0<\/span><span data-contrast=\"auto\">5\u00a0<\/span><span data-contrast=\"auto\">to December\u00a0<\/span><span data-contrast=\"auto\">31\u00a0<\/span><span data-contrast=\"auto\">2020. The model projects that cumulative total deaths across the US could reach 430,494 (288,046\u2013649,582) by December\u00a0<\/span><span data-contrast=\"auto\">31<\/span><span data-contrast=\"auto\">st<\/span><span data-contrast=\"auto\">,<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">2020. Greater than 60% of the deaths projected in this scenario would occur\u00a0<\/span><span data-contrast=\"auto\">in<\/span><span data-contrast=\"auto\">\u00a0five states:\u00a0<\/span><span data-contrast=\"auto\">California, Florida, Texas, Massachusetts, and Virginia.\u00a0<\/span><span data-contrast=\"auto\">The model indicates that a<\/span><span data-contrast=\"auto\">n emphasis on universal mask use<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">may\u00a0<\/span><span data-contrast=\"auto\">reduce<\/span><span data-contrast=\"auto\">\u00a0epidemic resurgences in many states, saving as many as 102,795 (<\/span><span data-contrast=\"auto\">95%CI\u00a0<\/span><span data-contrast=\"auto\">55,898<\/span><span data-contrast=\"auto\">\u00a0to\u00a0<\/span><span data-contrast=\"auto\">183,374) lives.\u00a0<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">I<\/span><\/i><i><span data-contrast=\"none\">HME COVID-19 Forecasting\u00a0<\/span><\/i><i><span data-contrast=\"none\">Team<\/span><\/i><i><span data-contrast=\"none\">\u00a0<\/span><\/i><i><span data-contrast=\"none\">(July 14, 2020). COVID-19 Scenarios for the United States. Pre-print\u00a0downloaded July 15 from\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.1101\/2020.07.12.20151191\"><span data-contrast=\"none\">https:\/\/doi.org\/10.1101\/2020.07.12.20151191<\/span><\/a><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<\/p>\n<\/div>\n<p>\t\t\t\t\t\t\t\t\t<!-- <a href=\"\" class=\"su-post-comments-link\"><\/a> --><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"js-accordion__panel\" >\n<h2 class=\"js-accordion__header\"><span class=\"TextRun SCXW256833614 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW256833614 BCX0\" data-ccp-parastyle=\"heading 2\">Public Health Policy and Practice<\/span><\/span><\/h2>\n<div class=\"su-posts su-posts-default-loop\">\n<div id=\"su-post-8255\" class=\"su-post\">\n<h5 class=\"su-post-title\">Outbreak of COVID-19 and Interventions in One of the Largest Jails in the United States Cook County IL 2020<\/h5>\n<p>\t\t\t\t<!-- \n\n\n\n\n\n\n\n\n\n\n\n<div class=\"su-post-meta\">\n\t\t\t\t\t: \t\t\t\t<\/div>\n\n\n\n\n\n\n\n\n\n\n\n --><\/p>\n<div class=\"su-post-excerpt\">\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"34\" data-aria-posinset=\"2019\" data-aria-level=\"1\"><i><span data-contrast=\"none\">[Preprint, not peer-reviewed]\u00a0<\/span><\/i><span data-contrast=\"auto\">During March 1-April 30, 907 cases of SARS-CoV-2 infection were detected among detained persons (n = 628) and staff (n = 279)\u00a0<\/span><span data-contrast=\"auto\">in the Cook County Jail (Chicago) and there were<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">9<\/span><span data-contrast=\"auto\">\u00a0deaths. Programmatic activity and visitation stopped\u00a0<\/span><span data-contrast=\"auto\">on\u00a0<\/span><span data-contrast=\"auto\">March 9,\u00a0<\/span><span data-contrast=\"auto\">and<\/span><span data-contrast=\"auto\">\u00a0cells were converted into single occupancy beginning March 26. Universal masking was implemented for staff (April 2) and detained\u00a0persons\u00a0(April 13). Cases at the jail declined while cases in Chicago increased.<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Zawitz\u00a0et al. (July 14, 2020). Outbreak of COVID-19 and Interventions in One of the Largest Jails in the United States Cook County IL 2020. Pre-print\u00a0downloaded July 15 from\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.1101\/2020.07.12.20148494\"><span data-contrast=\"none\">https:\/\/doi.org\/10.1101\/2020.07.12.20148494<\/span><\/a><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<\/p>\n<\/div>\n<p>\t\t\t\t\t\t\t\t\t<!-- <a href=\"\" class=\"su-post-comments-link\"><\/a> --><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<h3><strong>Other Resources and Commentaries<\/strong><\/h3>\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"34\" data-aria-posinset=\"2019\" data-aria-level=\"1\"><a href=\"https:\/\/doi.org\/10.1001\/jama.2020.11397\"><span data-contrast=\"none\">Researchers Home in on COVID-19 Severity Biomarkers<\/span><\/a><span data-contrast=\"auto\">\u00a0\u2013 JAMA (July\u00a0<\/span><span data-contrast=\"auto\">14<\/span><span data-contrast=\"auto\">)\u00a0<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"34\" data-aria-posinset=\"2019\" data-aria-level=\"1\"><a href=\"https:\/\/doi.org\/10.1001\/jama.2020.11582\"><span data-contrast=\"none\">COVID-19 Antibody Trials Have Begun<\/span><\/a><span data-contrast=\"auto\">\u00a0\u2013 JAMA (July\u00a0<\/span><span data-contrast=\"auto\">14<\/span><span data-contrast=\"auto\">)\u00a0<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"34\" data-aria-posinset=\"2019\" data-aria-level=\"1\"><a href=\"https:\/\/doi.org\/10.1016\/j.lfs.2020.118054\"><span data-contrast=\"none\">Tackling the Cytokine Storm in COVID-19, Challenges, and Hopes<\/span><\/a><span data-contrast=\"auto\">\u00a0\u2013 Life Sciences (July\u00a0<\/span><span data-contrast=\"auto\">11<\/span><span data-contrast=\"auto\">)\u00a0<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"34\" data-aria-posinset=\"2019\" data-aria-level=\"1\"><a href=\"https:\/\/doi.org\/10.1111\/tbed.13734\"><span data-contrast=\"none\">Hypothetical Targets and Plausible Drugs of Coronavirus Infection Caused by SARS\u2010CoV\u20102<\/span><\/a><span data-contrast=\"auto\">\u00a0\u2013 Transboundary and Emerging Diseases (July 13)\u00a0<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"34\" data-aria-posinset=\"2019\" data-aria-level=\"1\"><a href=\"https:\/\/doi.org\/10.1186\/s13000-020-00999-9\"><span data-contrast=\"none\">The Spectrum of Pathological Findings in Coronavirus Disease (COVID-19) and the Pathogenesis of SARS-CoV-2<\/span><\/a><span data-contrast=\"auto\">\u00a0\u2013 Diagnostic Pathology (<\/span><span data-contrast=\"auto\">July<\/span><span data-contrast=\"auto\">\u00a014)\u00a0<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"34\" data-aria-posinset=\"2019\" data-aria-level=\"1\"><a href=\"https:\/\/doi.org\/10.1001\/jama.2020.13107\"><span data-contrast=\"none\">Universal Masking to Prevent SARS-CoV-2 Transmission\u2014The Time Is Now<\/span><\/a><span data-contrast=\"auto\">\u00a0\u2013 JAMA (July 14)\u00a0<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"34\" data-aria-posinset=\"2019\" data-aria-level=\"1\"><a href=\"https:\/\/doi.org\/10.1101\/2020.07.11.20151563\"><span data-contrast=\"none\">Identification of Vulnerable Populations and Areas at Higher Risk of COVID-19 Related Mortality in the U.S<\/span><\/a><span data-contrast=\"none\">.<\/span><span data-contrast=\"auto\">\u00a0\u2013\u00a0<\/span><span data-contrast=\"auto\">Preprint<\/span><span data-contrast=\"auto\">\u00a0(July 14)\u00a0<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"34\" data-aria-posinset=\"2019\" data-aria-level=\"1\"><a href=\"https:\/\/doi.org\/10.1126\/science.abc8264\"><span data-contrast=\"none\">Unnecessary Hesitancy on Human Vaccine Tests<\/span><\/a><span data-contrast=\"auto\">\u00a0\u2013 Science (July 10)\u00a0<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"34\" data-aria-posinset=\"2019\" data-aria-level=\"1\"><a href=\"https:\/\/doi.org\/10.2105\/AJPH.2020.305826\"><span data-contrast=\"none\">Aligning Public Health Infrastructure and Medicaid to Fight COVID-19<\/span><\/a><span data-contrast=\"auto\">\u00a0\u2013 American Journal of Public Health (July\u00a0<\/span><span data-contrast=\"auto\">14<\/span><span data-contrast=\"auto\">)\u00a0<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"34\" data-aria-posinset=\"2019\" data-aria-level=\"1\"><a href=\"https:\/\/doi.org\/10.1074\/jbc.REV120.013930\"><span data-contrast=\"none\">The Molecular Virology of Coronaviruses<\/span><\/a><span data-contrast=\"auto\">\u00a0\u2013 The Journal of Biological Chemistry (July\u00a0<\/span><span data-contrast=\"auto\">13<\/span><span data-contrast=\"auto\">)\u00a0<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"34\" data-aria-posinset=\"2019\" data-aria-level=\"1\"><a href=\"https:\/\/doi.org\/10.1056\/NEJMe2025111\"><span data-contrast=\"none\">The Covid-19 Vaccine-Development Multiverse<\/span><\/a><span data-contrast=\"auto\">\u00a0\u2013 The New England Journal of Medicine (July\u00a0<\/span><span data-contrast=\"auto\">14<\/span><span data-contrast=\"auto\">)\u00a0<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"34\" data-aria-posinset=\"2019\" data-aria-level=\"1\"><a href=\"https:\/\/doi.org\/10.1017\/dmp.2020.241\"><span data-contrast=\"none\">COVID-19 Contact Tracing Solutions for Mass Gatherings<\/span><\/a><span data-contrast=\"auto\">\u00a0\u2013 Disaster Medicine and Public Health Preparedness (July\u00a0<\/span><span data-contrast=\"auto\">14<\/span><span data-contrast=\"auto\">)\u00a0<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"34\" data-aria-posinset=\"2019\" data-aria-level=\"1\"><a href=\"https:\/\/doi.org\/10.1136\/bmj.m2795\"><span data-contrast=\"none\">Covid-19: Disinfectants and Sanitisers Are Changing Microbiomes<\/span><\/a><span data-contrast=\"auto\">\u00a0\u2013 BMJ (July 14)\u00a0<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"34\" data-aria-posinset=\"2019\" data-aria-level=\"1\"><a href=\"https:\/\/doi.org\/10.1101\/2020.07.10.20150698\"><span data-contrast=\"none\">Subsequent Waves of Viral Pandemics a Hint for the Future Course of the SARS-CoV-2 Pandemic<\/span><\/a><span data-contrast=\"auto\">. \u2013\u00a0<\/span><span data-contrast=\"auto\">Preprint<\/span><span data-contrast=\"auto\">\u00a0(July 14)\u00a0<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"34\" data-aria-posinset=\"2019\" data-aria-level=\"1\"><a href=\"https:\/\/doi.org\/10.1101\/2020.07.13.20152355\"><span data-contrast=\"none\">State-Level Tracking of COVID-19 in the United States<\/span><\/a><span data-contrast=\"auto\">\u00a0\u2013\u00a0<\/span><span data-contrast=\"auto\">Preprint<\/span><span data-contrast=\"auto\">\u00a0(July 14)\u00a0<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"34\" data-aria-posinset=\"2019\" data-aria-level=\"1\"><a href=\"https:\/\/doi.org\/10.1007\/s11606-020-06025-4\"><span data-contrast=\"none\">The Invisible Epidemic: Neglected Chronic Disease Management During COVID-19<\/span><\/a><span data-contrast=\"auto\">\u00a0\u2013 Journal of General Internal Medicine (July 14<\/span><span data-contrast=\"auto\">)<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>A phase 1, dose-escalation, open-label trial of the candidate vaccine mRNA-1273 among 45 healthy adults found that all participants had serum neutralizing antibody activity after the second vaccination. No trial-limiting safety concerns were identified. <\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/07\/15\/outbreak-of-covid-19-and-interventions-in-one-of-the-largest-jails-in-the-united-states-cook-county-il-2020\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":343,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[5],"tags":[],"topic":[],"class_list":["post-8229","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-covid-19-literature-situation-report"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/8229","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=8229"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/8229\/revisions"}],"predecessor-version":[{"id":8257,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/8229\/revisions\/8257"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media\/343"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=8229"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=8229"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=8229"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=8229"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}