{"id":8268,"date":"2020-07-16T11:41:08","date_gmt":"2020-07-16T18:41:08","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=8268"},"modified":"2021-04-01T11:41:51","modified_gmt":"2021-04-01T18:41:51","slug":"risk-factors-associated-with-mortality-among-patients-with-covid-19-in-intensive-care-units-in-lombardy-italy","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/07\/16\/risk-factors-associated-with-mortality-among-patients-with-covid-19-in-intensive-care-units-in-lombardy-italy\/","title":{"rendered":"Risk Factors Associated\u00a0With\u00a0Mortality Among Patients With COVID-19 in Intensive Care Units in Lombardy, Italy"},"content":{"rendered":"<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"34\" data-aria-posinset=\"2019\" data-aria-level=\"1\"><span data-contrast=\"auto\">In a retrospective cohort study of critically ill patients admitted to ICUs in Italy (n=3,988), independent risk factors associated with mortality included older age<\/span><span data-contrast=\"auto\">\u00a0(HR=1.75<\/span><span data-contrast=\"auto\">)<\/span><span data-contrast=\"auto\">, male sex<\/span><span data-contrast=\"auto\">\u00a0(HR=<\/span><span data-contrast=\"auto\">1.57<\/span><span data-contrast=\"auto\">)<\/span><span data-contrast=\"auto\">, history of COPD<\/span><span data-contrast=\"auto\">\u00a0(<\/span><span data-contrast=\"auto\">HR = 1.68)<\/span><span data-contrast=\"auto\">,\u00a0<\/span><span data-contrast=\"auto\">history of\u00a0<\/span><span data-contrast=\"auto\">diabetes<\/span><span data-contrast=\"auto\">\u00a0(HR=<\/span><span data-contrast=\"auto\">1.18)<\/span><span data-contrast=\"auto\">,<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">hypercholesterolemia<\/span><span data-contrast=\"auto\">\u00a0(<\/span><span data-contrast=\"auto\">HR=1.25), and poor respiratory status\u00a0<\/span><span data-contrast=\"auto\">at ICU admission<\/span><span data-contrast=\"auto\">, as defined by\u00a0<\/span><span data-contrast=\"auto\">three measures<\/span><span data-contrast=\"auto\">. The hospital mortality rate as of May 30 was 12 per 1000 patient days after a median observation time of 70 days.\u00a0<\/span><span data-contrast=\"auto\">Eighty-seven percent of<\/span><span data-contrast=\"auto\">\u00a0patients required invasive mechanical ventilation<\/span><span data-contrast=\"auto\">\u00a0at the time of ICU admission<\/span><span data-contrast=\"auto\">.<\/span><span data-contrast=\"auto\">\u00a0Overall mortality was 48%<\/span><span data-contrast=\"auto\">\u00a0over a median follow-up period of\u00a0<\/span><span data-contrast=\"auto\">69 days (range\u00a0<\/span><span data-contrast=\"auto\">38-100).<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Grasselli\u00a0et al. (July 15, 2020). Risk Factors Associated\u00a0With\u00a0Mortality Among Patients With COVID-19 in Intensive Care Units in Lombardy, Italy. JAMA Internal Medicine.\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.1001\/jamainternmed.2020.3539\"><span data-contrast=\"none\">https:\/\/doi.org\/10.1001\/jamainternmed.2020.3539<\/span><\/a><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>In a retrospective cohort study of critically ill patients admitted to ICUs in Italy (n=3,988), independent risk factors associated with mortality included older age\u00a0(HR=1.75), male sex\u00a0(HR=1.57), history of COPD\u00a0(HR = 1.68),\u00a0history of\u00a0diabetes\u00a0(HR=1.18),\u00a0hypercholesterolemia\u00a0(HR=1.25), and poor respiratory status\u00a0at ICU admission, as defined by\u00a0three measures. The hospital mortality rate as of May 30 was 12 per 1000 patient&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/07\/16\/risk-factors-associated-with-mortality-among-patients-with-covid-19-in-intensive-care-units-in-lombardy-italy\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[],"topic":[20],"class_list":["post-8268","post","type-post","status-publish","format-standard","hentry","category-article-summary","topic-clinical-characteristics-and-health-care-setting"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/8268","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=8268"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/8268\/revisions"}],"predecessor-version":[{"id":8269,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/8268\/revisions\/8269"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=8268"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=8268"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=8268"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=8268"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}