{"id":8324,"date":"2020-07-17T15:16:49","date_gmt":"2020-07-17T22:16:49","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=8324"},"modified":"2021-04-02T15:29:15","modified_gmt":"2021-04-02T22:29:15","slug":"vascular-risk-factors-framingham-risk-score-and-covid-19-community-based-cohort-study-2","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/07\/17\/vascular-risk-factors-framingham-risk-score-and-covid-19-community-based-cohort-study-2\/","title":{"rendered":"SARS-CoV-2 Infection Induces Robust Neutralizing Antibody Responses That Are Stable for at Least Three Months"},"content":{"rendered":"<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"43\" data-aria-posinset=\"1\" data-aria-level=\"1\"><i><span data-contrast=\"none\">[pre-print, not peer-reviewed]<\/span><\/i><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">Among\u00a0<\/span><span data-contrast=\"auto\">over 50,000 individuals with confirmed or suspected SARS-CoV-2<\/span><span data-contrast=\"auto\">\u00a0infection<\/span><span data-contrast=\"auto\">\u00a0or exposure\u00a0<\/span><span data-contrast=\"auto\">to\u00a0<\/span><span data-contrast=\"auto\">someone with\u00a0<\/span><span data-contrast=\"auto\">COVID-19<\/span><span data-contrast=\"auto\">, n<\/span><span data-contrast=\"auto\">early 20,000 individuals\u00a0<\/span><span data-contrast=\"auto\">had detectable antibodies<\/span><span data-contrast=\"auto\">. O<\/span><span data-contrast=\"auto\">f\u00a0<\/span><span data-contrast=\"auto\">those who were antibody positive,\u00a0<\/span><span data-contrast=\"auto\">22% had moderate<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">and 7<\/span><span data-contrast=\"auto\">1<\/span><span data-contrast=\"auto\">% had high titers for anti-spike antibodies. Approximately half of the samples with low titers were able to neutralize virus, versus 90%\u00a0<\/span><span data-contrast=\"auto\">and 100%\u00a0<\/span><span data-contrast=\"auto\">of the samples with moderate\u00a0<\/span><span data-contrast=\"auto\">and<\/span><span data-contrast=\"auto\">\u00a0high titers<\/span><span data-contrast=\"auto\">, respectively<\/span><span data-contrast=\"auto\">.\u00a0<\/span><span data-contrast=\"auto\">Among 121 donors selected for repeat titers (at a\u00a0mean\u00a0of 82 days post symptom onset),\u00a0<\/span><span data-contrast=\"auto\">there was\u00a0<\/span><span data-contrast=\"auto\">a slight drop in mean titer\u00a0<\/span><span data-contrast=\"auto\">among those<\/span><span data-contrast=\"auto\">\u00a0with high titers,\u00a0<\/span><span data-contrast=\"auto\">while titers\u00a0<\/span><span data-contrast=\"auto\">increase<\/span><span data-contrast=\"auto\">d<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">among those with\u00a0<\/span><span data-contrast=\"auto\">initially low to moderate titers.\u00a0<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Wajnberg\u00a0et al. (July 17, 2020). SARS-CoV-2 Infection Induces Robust Neutralizing Antibody Responses That Are Stable for at Least Three Months.\u00a0<\/span><\/i><i><span data-contrast=\"none\">Pre-print\u00a0downloaded July 17 from\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.1101\/2020.07.14.20151126\"><i><span data-contrast=\"none\">https:\/\/doi.org\/10.1101\/2020.07.14.20151126<\/span><\/i><\/a><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>[pre-print, not peer-reviewed]\u00a0Among\u00a0over 50,000 individuals with confirmed or suspected SARS-CoV-2\u00a0infection\u00a0or exposure\u00a0to\u00a0someone with\u00a0COVID-19, nearly 20,000 individuals\u00a0had detectable antibodies. Of\u00a0those who were antibody positive,\u00a022% had moderate\u00a0and 71% had high titers for anti-spike antibodies. Approximately half of the samples with low titers were able to neutralize virus, versus 90%\u00a0and 100%\u00a0of the samples with moderate\u00a0and\u00a0high titers, respectively.\u00a0Among 121 donors&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/07\/17\/vascular-risk-factors-framingham-risk-score-and-covid-19-community-based-cohort-study-2\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[],"topic":[20],"class_list":["post-8324","post","type-post","status-publish","format-standard","hentry","category-article-summary","topic-clinical-characteristics-and-health-care-setting"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/8324","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=8324"}],"version-history":[{"count":2,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/8324\/revisions"}],"predecessor-version":[{"id":8339,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/8324\/revisions\/8339"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=8324"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=8324"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=8324"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=8324"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}