{"id":8348,"date":"2020-07-20T15:35:30","date_gmt":"2020-07-20T22:35:30","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=8348"},"modified":"2021-04-02T15:36:21","modified_gmt":"2021-04-02T22:36:21","slug":"dexamethasone-in-hospitalized-patients-with-covid-19-preliminary-report-2","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/07\/20\/dexamethasone-in-hospitalized-patients-with-covid-19-preliminary-report-2\/","title":{"rendered":"Dexamethasone in Hospitalized Patients with Covid-19 \u2014 Preliminary Report"},"content":{"rendered":"<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"34\" data-aria-posinset=\"2019\" data-aria-level=\"1\"><span data-contrast=\"auto\">In\u00a0<\/span><span data-contrast=\"auto\">the<\/span><span data-contrast=\"auto\">\u00a0open-label\u00a0<\/span><span data-contrast=\"auto\">RECOVERY<\/span><span data-contrast=\"auto\">\u00a0trial among hospitalized COVID-19 patients,\u00a0Horby\u00a0et al. found that 28-day mortality was lower\u00a0<\/span><span data-contrast=\"auto\">for patients receiving\u00a0<\/span><span data-contrast=\"auto\">the steroid\u00a0<\/span><span data-contrast=\"auto\">dexamethasone\u00a0<\/span><span data-contrast=\"auto\">than\u00a0<\/span><span data-contrast=\"auto\">for<\/span><span data-contrast=\"auto\">\u00a0the<\/span><span data-contrast=\"auto\">\u00a0usual care group among patients receiving invasive mechanical ventilation (29% vs. 41%)\u00a0<\/span><span data-contrast=\"auto\">or<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">supplemental<\/span><span data-contrast=\"auto\">\u00a0oxygen without invasive mechanical ventilation (23% vs. 26%), but not among those who were receiving no respiratory support at randomization (1<\/span><span data-contrast=\"auto\">8<\/span><span data-contrast=\"auto\">% vs. 14%).<\/span><span data-contrast=\"auto\">\u00a0<\/span><i><span data-contrast=\"auto\">[EDITORIAL NOTE: A version of these findings\u00a0<\/span><\/i><i><span data-contrast=\"auto\">was<\/span><\/i><i><span data-contrast=\"auto\">\u00a0published as a pre-print article\u00a0<\/span><\/i><i><span data-contrast=\"auto\">that was\u00a0<\/span><\/i><i><span data-contrast=\"auto\">included in this Literature Report on June 23, 2020]<\/span><\/i><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Horby\u00a0et al. (July 17, 2020). Dexamethasone in Hospitalized Patients with Covid-19 \u2014 Preliminary Report. New England Journal of Medicine.\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.1056\/NEJMoa2021436\"><span data-contrast=\"none\">https:\/\/doi.org\/10.1056\/NEJMoa2021436<\/span><\/a><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>In\u00a0the\u00a0open-label\u00a0RECOVERY\u00a0trial among hospitalized COVID-19 patients,\u00a0Horby\u00a0et al. found that 28-day mortality was lower\u00a0for patients receiving\u00a0the steroid\u00a0dexamethasone\u00a0than\u00a0for\u00a0the\u00a0usual care group among patients receiving invasive mechanical ventilation (29% vs. 41%)\u00a0or\u00a0supplemental\u00a0oxygen without invasive mechanical ventilation (23% vs. 26%), but not among those who were receiving no respiratory support at randomization (18% vs. 14%).\u00a0[EDITORIAL NOTE: A version of these findings\u00a0was\u00a0published as&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/07\/20\/dexamethasone-in-hospitalized-patients-with-covid-19-preliminary-report-2\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[],"topic":[19],"class_list":["post-8348","post","type-post","status-publish","format-standard","hentry","category-article-summary","topic-testing-and-treatment"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/8348","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=8348"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/8348\/revisions"}],"predecessor-version":[{"id":8349,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/8348\/revisions\/8349"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=8348"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=8348"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=8348"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=8348"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}