{"id":8367,"date":"2020-07-21T15:44:22","date_gmt":"2020-07-21T22:44:22","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=8367"},"modified":"2021-04-02T16:11:02","modified_gmt":"2021-04-02T23:11:02","slug":"covid-19-literature-situation-report-july-21-2020","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/07\/21\/covid-19-literature-situation-report-july-21-2020\/","title":{"rendered":"COVID-19 Literature Situation Report July 21, 2020"},"content":{"rendered":"<p>The scientific literature on COVID-19 is rapidly evolving and these articles were selected for review based on their relevance to Washington State decision making around COVID-19 response efforts. Included in these Lit Reps are some manuscripts that have been made available online as pre-prints but have not yet undergone peer review. Please be aware of this when reviewing articles included in the Lit Reps.<\/p>\n<h2>Key Takeaways<\/h2>\n<ul>\n<li><b><span data-contrast=\"auto\">A seroprevalence study in Blaine County, Idaho, a resort community with a high incidence of COVID-19 in March and April<\/span><\/b><b><span data-contrast=\"auto\">, f<\/span><\/b><b><span data-contrast=\"auto\">ound\u00a0<\/span><\/b><b><span data-contrast=\"auto\">nearly\u00a0<\/span><\/b><b><span data-contrast=\"auto\">a\u00a0<\/span><\/b><b><span data-contrast=\"auto\">quarter of residents were positive for SARS-CoV-2<\/span><\/b><b><span data-contrast=\"auto\">\u00a0antibodies<\/span><\/b><b><span data-contrast=\"auto\">.<\/span><\/b><span data-contrast=\"auto\">\u00a0<\/span><a href=\"https:\/\/doi.org\/10.1101\/2020.07.19.20157198\"><span data-contrast=\"none\">More<\/span><\/a><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0d8\" data-font=\"Wingdings\" data-listid=\"1\" data-aria-posinset=\"1\" data-aria-level=\"1\"><b><span data-contrast=\"auto\">Mass testing in long term care facilities in San Francisco documented a large proportion of COVID-19 cases<\/span><\/b><b><span data-contrast=\"auto\">\u00a0that\u00a0<\/span><\/b><b><span data-contrast=\"auto\">were asymptomatic. Of the health care workers identified as the likely index case in each facility,\u00a0<\/span><\/b><b><span data-contrast=\"auto\">3 out of 4<\/span><\/b><b><span data-contrast=\"auto\">\u00a0reported working while symptomatic despite temperature and symptom surveillance before each shift.<\/span><\/b><span data-contrast=\"auto\">\u00a0<\/span><a href=\"https:\/\/doi.org\/10.1093\/cid\/ciaa1020\"><span data-contrast=\"none\">More<\/span><\/a><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0d8\" data-font=\"Wingdings\" data-listid=\"1\" data-aria-posinset=\"2\" data-aria-level=\"1\"><b><span data-contrast=\"auto\">In a cohort<\/span><\/b><b><span data-contrast=\"auto\">\u00a0of\u00a0<\/span><\/b><b><span data-contrast=\"auto\">91 pregnant women with SARS-CoV-2 infection in Spain, the rate of hospitalization and ICU admission were double the corresponding rates for non-pregnant\u00a0<\/span><\/b><b><span data-contrast=\"auto\">women\u00a0<\/span><\/b><b><span data-contrast=\"auto\">of the same age.\u00a0<\/span><\/b><b><span data-contrast=\"auto\">C<\/span><\/b><b><span data-contrast=\"auto\">esarean section rates were more than three times higher among\u00a0<\/span><\/b><b><span data-contrast=\"auto\">women<\/span><\/b><b><span data-contrast=\"auto\">\u00a0hospitalized due to COVID-19<\/span><\/b><b><span data-contrast=\"auto\">\u00a0compared to pregnant women<\/span><\/b><b><span data-contrast=\"auto\">\u00a0hospitalized for other reasons<\/span><\/b><b><span data-contrast=\"auto\">.<\/span><\/b><span data-contrast=\"auto\">\u00a0<\/span><a href=\"https:\/\/doi.org\/10.1080\/14767058.2020.1793320\"><span data-contrast=\"none\">More<\/span><\/a><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0d8\" data-font=\"Wingdings\" data-listid=\"1\" data-aria-posinset=\"3\" data-aria-level=\"1\"><b><span data-contrast=\"auto\">A modeling study found that<\/span><\/b><b><span data-contrast=\"auto\">,<\/span><\/b><b><span data-contrast=\"auto\">\u00a0while the use of face masks could contribute to the control of the spread of SARS-CoV-2, scenarios in which mask wearers are more likely to mix with other mask wearers than with non-mask wearers will reduce the effect of face masks on population-level transmission.<\/span><\/b><span data-contrast=\"auto\">\u00a0<\/span><a href=\"https:\/\/doi.org\/10.1016\/j.idm.2020.06.004\"><span data-contrast=\"none\">More<\/span><\/a><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<div id=\"uw-accordion-shortcode\">\n<h3>Article Summaries<\/h3>\n<div class=\"js-accordion\" data-accordion-prefix-classes=\"uw-accordion-shortcode\">\n<div class=\"js-accordion__panel\" >\n<h2 class=\"js-accordion__header\"><span class=\"TextRun SCXW22556128 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW22556128 BCX0\" data-ccp-parastyle=\"heading 2\">Non-Pharmaceutical Interventions<\/span><\/span><\/h2>\n<div class=\"su-posts su-posts-default-loop\">\n<div id=\"su-post-8369\" class=\"su-post\">\n<h5 class=\"su-post-title\">Decontaminating N95 and SN95 Masks with Ultraviolet Germicidal Irradiation (UVGI) Does Not Impair Mask Efficacy and Safety: A Systematic Review<\/h5>\n<p>\t\t\t\t<!-- \n\n\n\n\n\n\n\n\n\n\n\n<div class=\"su-post-meta\">\n\t\t\t\t\t: \t\t\t\t<\/div>\n\n\n\n\n\n\n\n\n\n\n\n --><\/p>\n<div class=\"su-post-excerpt\">\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"47\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"auto\">A systematic review (n=13 studies) found that filtering fac<\/span><span data-contrast=\"auto\">e<\/span><span data-contrast=\"auto\">piece\u00a0respirators\u00a0<\/span><span data-contrast=\"auto\">maintained\u00a0<\/span><span data-contrast=\"auto\">certification standards following ultraviolet germicidal irradiation (UVGI), and that UVGI did not compromise fit. UVGI protocols using a cumulative dose of &gt;40,000 J\/m<\/span><span data-contrast=\"auto\">2<\/span><span data-contrast=\"auto\">\u00a0resulted in a 3<\/span><span data-contrast=\"auto\">&#8211;<\/span><span data-contrast=\"auto\">log reduction in viral load, versus 2<\/span><span data-contrast=\"auto\">&#8211;<\/span><span data-contrast=\"auto\">log reduction in viral load for<\/span><span data-contrast=\"auto\">\u00a0with a<\/span><span data-contrast=\"auto\">\u00a0cumulative dose &gt;20,000 J\/m<\/span><span data-contrast=\"auto\">2<\/span><span data-contrast=\"auto\">.<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Katie et al. (July 13, 2020). Decontaminating N95 and SN95 Masks with Ultraviolet Germicidal Irradiation (UVGI) Does Not Impair Mask Efficacy and Safety: A Systematic Review. Journal of Hospital Infection.<\/span><\/i><i><span data-contrast=\"auto\">\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.1016\/j.jhin.2020.07.014\"><i><span data-contrast=\"none\">https:\/\/doi.org\/10.1016\/j.jhin.2020.07.014<\/span><\/i><\/a><i><span data-contrast=\"auto\">\u00a0<\/span><\/i><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<\/p>\n<\/div>\n<p>\t\t\t\t\t\t\t\t\t<!-- <a href=\"\" class=\"su-post-comments-link\"><\/a> --><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"js-accordion__panel\" >\n<h2 class=\"js-accordion__header\"><span class=\"TextRun SCXW70641427 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW70641427 BCX0\" data-ccp-parastyle=\"heading 2\">Transmission<\/span><\/span><\/h2>\n<div class=\"su-posts su-posts-default-loop\">\n<div id=\"su-post-8380\" class=\"su-post\">\n<h5 class=\"su-post-title\">Seroprevalence of Antibodies to SARS-CoV-2 in 10 Sites in the United States, March 23-May 12, 2020<\/h5>\n<p>\t\t\t\t<!-- \n\n\n\n\n\n\n\n\n\n\n\n<div class=\"su-post-meta\">\n\t\t\t\t\t: \t\t\t\t<\/div>\n\n\n\n\n\n\n\n\n\n\n\n --><\/p>\n<div class=\"su-post-excerpt\">\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"47\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"auto\">Havers et al. report<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">a cross-sectional sero<\/span><span data-contrast=\"auto\">prevalence\u00a0<\/span><span data-contrast=\"auto\">survey conducted on a convenience sample of residual sera collected from March 23 through May 12 for routine clinical testing in San Francisco (SF), Connecticut (CT), south Florida (SF), Louisiana (LA), Minneapolis-St Paul-St Cloud metro area (MN), Missouri (MS), New York City Metro Area (NYC), Philadelphia metro area (PA), Utah (UT), and western Washington state (WA) (n=16,025 individuals). Seropositivity ranged from 1% in SF (late April) to\u00a0<\/span><span data-contrast=\"auto\">7<\/span><span data-contrast=\"auto\">% in NYC (late March\/early April)<\/span><span data-contrast=\"auto\">.\u00a0<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"47\" data-aria-posinset=\"2\" data-aria-level=\"1\"><span data-contrast=\"auto\">The e<\/span><span data-contrast=\"auto\">stimated number of infections ranged from 6<\/span><span data-contrast=\"auto\">&#8211;<\/span><span data-contrast=\"auto\">\u00a0to\u00a0<\/span><span data-contrast=\"auto\">24<\/span><span data-contrast=\"auto\">&#8211;<\/span><span data-contrast=\"auto\">times the number of\u00a0reported cases.\u00a0<\/span><i><span data-contrast=\"auto\">[<\/span><\/i><i><span data-contrast=\"auto\">EDITORIAL NOTE<\/span><\/i><i><span data-contrast=\"auto\">: Seropositivity in individuals undergoing routine clinical testing may not reflect\u00a0<\/span><\/i><i><span data-contrast=\"auto\">seropositivity in the general population.<\/span><\/i><i><span data-contrast=\"auto\">\u00a0A version of these findings was published as a pre-print article that was included in this Literature Report on June 2<\/span><\/i><i><span data-contrast=\"auto\">9, 2020<\/span><\/i><i><span data-contrast=\"auto\">]<\/span><\/i><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Havers et al. (July 21, 2020). Seroprevalence of Antibodies to SARS-CoV-2 in 10 Sites in the United States, March 23-May 12, 2020. JAMA Internal Medicine.\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.1001\/jamainternmed.2020.4130\"><i><span data-contrast=\"none\">https:\/\/doi.org\/10.1001\/jamainternmed.2020.4130<\/span><\/i><\/a><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<\/p>\n<\/div>\n<p>\t\t\t\t\t\t\t\t\t<!-- <a href=\"\" class=\"su-post-comments-link\"><\/a> --><\/p>\n<\/div>\n<div id=\"su-post-8378\" class=\"su-post\">\n<h5 class=\"su-post-title\">Population Point Prevalence of SARS-CoV-2 Infection Based on a Statewide Random Sample \u2014 Indiana, April 25\u201329, 2020<\/h5>\n<p>\t\t\t\t<!-- \n\n\n\n\n\n\n\n\n\n\n\n<div class=\"su-post-meta\">\n\t\t\t\t\t: \t\t\t\t<\/div>\n\n\n\n\n\n\n\n\n\n\n\n --><\/p>\n<div class=\"su-post-excerpt\">\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"47\" data-aria-posinset=\"2\" data-aria-level=\"1\"><span data-contrast=\"auto\">A<\/span><span data-contrast=\"auto\">\u00a0state-wide study\u00a0<\/span><span data-contrast=\"auto\">from Indiana\u00a0<\/span><span data-contrast=\"auto\">conducted on a random statewide sample of non-institutionalized residents\u00a0<\/span><span data-contrast=\"auto\">(<\/span><span data-contrast=\"auto\">12 years or older<\/span><span data-contrast=\"auto\">)<\/span><span data-contrast=\"auto\">\u00a0from April 25-29 (n=3,658, representing a 2<\/span><span data-contrast=\"auto\">4<\/span><span data-contrast=\"auto\">% response rate)<\/span><span data-contrast=\"auto\">\u00a0e<\/span><span data-contrast=\"auto\">stimated\u00a0<\/span><span data-contrast=\"auto\">the\u00a0<\/span><span data-contrast=\"auto\">prevalence of active infection<\/span><span data-contrast=\"auto\">, based on RT-PCR testing,<\/span><span data-contrast=\"auto\">\u00a0was\u00a0<\/span><span data-contrast=\"auto\">1.<\/span><span data-contrast=\"auto\">7<\/span><span data-contrast=\"auto\">%, with 44% reporting no positive symptoms in the preceding two weeks. Estimated seropositivity was 1.1%, bringing overall prevalence of current and previous infections to 2.<\/span><span data-contrast=\"auto\">8<\/span><span data-contrast=\"auto\">%.\u00a0 Overall prevalence was significantly higher among Hispanic<\/span><span data-contrast=\"auto\">\u00a0respondents<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">(<\/span><span data-contrast=\"auto\">8.3%<\/span><span data-contrast=\"auto\">)<\/span><span data-contrast=\"auto\">, and among individuals reporting a household member who had previously been told they had COVID-19 (33.6%). Among a non-random sample recruited from a more racially and ethnically diverse group, 22.8% were positive\u00a0<\/span><span data-contrast=\"auto\">by\u00a0<\/span><span data-contrast=\"auto\">RT-<\/span><span data-contrast=\"auto\">PCR (20% asymptomatic)<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">and 5.8% were seropositive.\u00a0<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Menachemi\u00a0et al. (July 21, 2020). Population Point Prevalence of SARS-CoV-2 Infection Based on a Statewide Random Sample \u2014 Indiana, April 25\u201329, 2020. MMWR.<\/span><\/i><i><span data-contrast=\"none\">\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.15585\/mmwr.mm6929e1\"><i><span data-contrast=\"none\">https:\/\/doi.org\/10.15585\/mmwr.mm6929e1<\/span><\/i><\/a><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<\/p>\n<\/div>\n<p>\t\t\t\t\t\t\t\t\t<!-- <a href=\"\" class=\"su-post-comments-link\"><\/a> --><\/p>\n<\/div>\n<div id=\"su-post-8376\" class=\"su-post\">\n<h5 class=\"su-post-title\">Estimated Community Seroprevalence of SARS-CoV-2 Antibodies \u2014 Two Georgia Counties, April 28\u2013May 3, 2020<\/h5>\n<p>\t\t\t\t<!-- \n\n\n\n\n\n\n\n\n\n\n\n<div class=\"su-post-meta\">\n\t\t\t\t\t: \t\t\t\t<\/div>\n\n\n\n\n\n\n\n\n\n\n\n --><\/p>\n<div class=\"su-post-excerpt\">\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"47\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"auto\">A s<\/span><span data-contrast=\"auto\">eroprevalence study conducted<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">April 28<\/span><span data-contrast=\"auto\">&#8211;<\/span><span data-contrast=\"auto\">May 3 in two high-incidence counties in metropolitan Atlanta (n=394 households and 696 people)<\/span><span data-contrast=\"auto\">\u00a0found an e<\/span><span data-contrast=\"auto\">stimated seroprevalence\u00a0<\/span><span data-contrast=\"auto\">of\u00a0<\/span><span data-contrast=\"auto\">3<\/span><span data-contrast=\"auto\">%<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">overall, and 5% among non-Hispanic Black participants. Of those seropositive,\u00a0<\/span><span data-contrast=\"auto\">50<\/span><span data-contrast=\"auto\">% reported<\/span><span data-contrast=\"auto\">\u00a0illness or symptoms consistent with\u00a0<\/span><span data-contrast=\"auto\">COVID-19, of whom 28% sought care and 1<\/span><span data-contrast=\"auto\">6<\/span><span data-contrast=\"auto\">% were tested, demonstrating that many infections would not have been identified through case-based or syndromic surveillance.<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Biggs et al. (July 21, 2020). Estimated Community Seroprevalence of SARS-CoV-2 Antibodies \u2014 Two Georgia Counties, April 28\u2013May 3, 2020. MMWR.<\/span><\/i><i><span data-contrast=\"none\">\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.15585\/mmwr.mm6929e2\"><span data-contrast=\"none\">https:\/\/doi.org\/10.15585\/mmwr.mm6929e2<\/span><\/a><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<\/p>\n<\/div>\n<p>\t\t\t\t\t\t\t\t\t<!-- <a href=\"\" class=\"su-post-comments-link\"><\/a> --><\/p>\n<\/div>\n<div id=\"su-post-8374\" class=\"su-post\">\n<h5 class=\"su-post-title\">High Community SARS-CoV-2 Antibody Seroprevalence in a Ski Resort Community Blaine County Idaho US. Preliminary Results<\/h5>\n<p>\t\t\t\t<!-- \n\n\n\n\n\n\n\n\n\n\n\n<div class=\"su-post-meta\">\n\t\t\t\t\t: \t\t\t\t<\/div>\n\n\n\n\n\n\n\n\n\n\n\n --><\/p>\n<div class=\"su-post-excerpt\">\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"44\" data-aria-posinset=\"2\" data-aria-level=\"1\"><i><span data-contrast=\"none\">[pre-print, not peer-reviewed]<\/span><\/i><span data-contrast=\"none\">\u00a0<\/span><span data-contrast=\"auto\">A r<\/span><span data-contrast=\"auto\">epresentative sero<\/span><span data-contrast=\"auto\">prevalence\u00a0<\/span><span data-contrast=\"auto\">survey of residents of Blaine County, Idaho, a resort community with a high incidence of COVID-19 in March and April<\/span><span data-contrast=\"auto\">, f<\/span><span data-contrast=\"auto\">ound\u00a0<\/span><span data-contrast=\"auto\">that\u00a0<\/span><span data-contrast=\"auto\">2<\/span><span data-contrast=\"auto\">3<\/span><span data-contrast=\"auto\">%\u00a0<\/span><span data-contrast=\"auto\">of residents had antibodies against SARS-CoV-2. Based on the number of reported cases, this suggests that\u00a0<\/span><span data-contrast=\"auto\">more than 80% of SARS-CoV-2 infections were not reported.<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">McLaughlin et al. (July 21, 2020). High Community SARS-CoV-2 Antibody Seroprevalence in a Ski Resort Community Blaine County Idaho US. Preliminary Results.\u00a0<\/span><\/i><i><span data-contrast=\"none\">Pre-print\u00a0downloaded July 21 from<\/span><\/i><i><span data-contrast=\"none\">\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.1101\/2020.07.19.20157198\"><span data-contrast=\"none\">https:\/\/doi.org\/10.1101\/2020.07.19.20157198<\/span><\/a><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<\/p>\n<\/div>\n<p>\t\t\t\t\t\t\t\t\t<!-- <a href=\"\" class=\"su-post-comments-link\"><\/a> --><\/p>\n<\/div>\n<div id=\"su-post-8371\" class=\"su-post\">\n<h5 class=\"su-post-title\">Coronavirus Disease 2019 (COVID-19): A Systematic Review of Pregnancy and the Possibility of Vertical Transmission<\/h5>\n<p>\t\t\t\t<!-- \n\n\n\n\n\n\n\n\n\n\n\n<div class=\"su-post-meta\">\n\t\t\t\t\t: \t\t\t\t<\/div>\n\n\n\n\n\n\n\n\n\n\n\n --><\/p>\n<div class=\"su-post-excerpt\">\n<ul>\n<li><span data-contrast=\"auto\">A<\/span><span data-contrast=\"auto\">\u00a0systematic literature review of COVID-19\u00a0<\/span><span data-contrast=\"auto\">in pregnan<\/span><span data-contrast=\"auto\">t women<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">and neonates<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">(n=21 studies corresponding to 90 pregnancies and 92 neonates)<\/span><span data-contrast=\"auto\">\u00a0found that the most common symptoms among pregnant women were<\/span><span data-contrast=\"auto\">\u00a0fever, cough, and\u00a0<\/span><span data-contrast=\"auto\">difficulty breathing.\u00a0<\/span><span data-contrast=\"auto\">Three<\/span><span data-contrast=\"auto\">\u00a0women were admitted to\u00a0<\/span><span data-contrast=\"auto\">the\u00a0<\/span><span data-contrast=\"auto\">ICU and required mechanical ventilation,\u00a0<\/span><span data-contrast=\"auto\">including\u00a0<\/span><span data-contrast=\"auto\">one woman\u00a0<\/span><span data-contrast=\"auto\">who\u00a0<\/span><span data-contrast=\"auto\">died and\u00a0<\/span><span data-contrast=\"auto\">an<\/span><span data-contrast=\"auto\">other\u00a0<\/span><span data-contrast=\"auto\">who<\/span><span data-contrast=\"auto\">\u00a0was still receiving intensive care at the time of publication. The most\u00a0commonly<\/span><span data-contrast=\"auto\">&#8211;<\/span><span data-contrast=\"auto\">reported\u00a0complication<\/span><span data-contrast=\"auto\">s<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">were preterm labor (n=29), fetal distress (n=15), premature rupture of membranes (n=6), chorioamnionitis (n=1) and stillbirth (n=1).\u00a0<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"43\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"auto\">Four out of 86<\/span><span data-contrast=\"auto\">\u00a0(5%)<\/span><span data-contrast=\"auto\">\u00a0neonates tested for SARS-CoV-2 were positive. One neonate was negative at birth and positive 24 hours later; a corresponding amniotic fluid sample was positive, but cord blood was negative.\u00a0<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:240}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Ashraf et al. (2020). Coronavirus Disease 2019 (COVID-19): A Systematic Review of Pregnancy and the Possibility of Vertical Transmission. Journal of Reproduction &amp; Infertility.\u00a0<\/span><\/i><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/32685412\"><i><span data-contrast=\"none\">http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/32685412<\/span><\/i><\/a><i><span data-contrast=\"auto\">\u00a0<\/span><\/i><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:240}\">\u00a0<\/span><\/p>\n<\/p>\n<\/div>\n<p>\t\t\t\t\t\t\t\t\t<!-- <a href=\"\" class=\"su-post-comments-link\"><\/a> --><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"js-accordion__panel\" >\n<h2 class=\"js-accordion__header\"><span class=\"TextRun SCXW70641427 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW70641427 BCX0\" data-ccp-parastyle=\"heading 2\"><span class=\"TextRun SCXW129411030 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW129411030 BCX0\" data-ccp-parastyle=\"heading 2\">Geographic Spread<\/span><\/span><\/span><\/span><\/h2>\n<div class=\"su-posts su-posts-default-loop\">\n<div id=\"su-post-8382\" class=\"su-post\">\n<h5 class=\"su-post-title\">COVID-19 and Inequity:\u00a0A Comparative\u00a0Spatial Analysis of New York City and Chicago Hot Spots<\/h5>\n<p>\t\t\t\t<!-- \n\n\n\n\n\n\n\n\n\n\n\n<div class=\"su-post-meta\">\n\t\t\t\t\t: \t\t\t\t<\/div>\n\n\n\n\n\n\n\n\n\n\n\n --><\/p>\n<div class=\"su-post-excerpt\">\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"47\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"auto\">An ecological study of COVID-19 hotspots in New York City and Chicago found that hot spots\u00a0<\/span><span data-contrast=\"auto\">included ZIP codes<\/span><span data-contrast=\"auto\">\u00a0with<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">lower rates of college graduates and higher proportions of people of color<\/span><span data-contrast=\"auto\">;\u00a0<\/span><span data-contrast=\"auto\">however<\/span><span data-contrast=\"auto\">,<\/span><span data-contrast=\"auto\">\u00a0household size had a stronger effect than population density.\u00a0<\/span><span data-contrast=\"auto\">New York City\u00a0<\/span><span data-contrast=\"auto\">hotspots tended to be\u00a0<\/span><span data-contrast=\"auto\">among\u00a0<\/span><span data-contrast=\"auto\">more working-class and middle-income<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">neighborhoods<\/span><span data-contrast=\"auto\">, while Chicago\u2019s hot spots\u00a0<\/span><span data-contrast=\"auto\">occurred more commonly\u00a0<\/span><span data-contrast=\"auto\">among the neighborhoods with high rates of poverty and unemployment.\u00a0<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Maroko\u00a0et al. (July 20, 2020). COVID-19 and Inequity:\u00a0A Comparative\u00a0Spatial Analysis of New York City and Chicago Hot Spots. Journal of Urban Health.\u00a0<\/span><\/i><br \/>\n<a href=\"https:\/\/doi.org\/10.1007\/s11524-020-00468-0\"><span data-contrast=\"none\">https:\/\/doi.org\/10.1007\/s11524-020-00468-0<\/span><\/a><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<\/p>\n<\/div>\n<p>\t\t\t\t\t\t\t\t\t<!-- <a href=\"\" class=\"su-post-comments-link\"><\/a> --><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"js-accordion__panel\" >\n<h2 class=\"js-accordion__header\"><span class=\"TextRun SCXW173333515 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW173333515 BCX0\" data-ccp-parastyle=\"heading 2\">Testing and Treatment<\/span><\/span><\/h2>\n<div class=\"su-posts su-posts-default-loop\">\n<div id=\"su-post-8384\" class=\"su-post\">\n<h5 class=\"su-post-title\">Experience with Tocilizumab in Severe COVID-19 Pneumonia after 80 Days of Follow-up: A Retrospective Cohort Study<\/h5>\n<p>\t\t\t\t<!-- \n\n\n\n\n\n\n\n\n\n\n\n<div class=\"su-post-meta\">\n\t\t\t\t\t: \t\t\t\t<\/div>\n\n\n\n\n\n\n\n\n\n\n\n --><\/p>\n<div class=\"su-post-excerpt\">\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"43\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"auto\">Among 236 patients with severe COVID-19 pneumoni<\/span><span data-contrast=\"auto\">a treated with tocilizumab over a median follow-up of 83 days<\/span><span data-contrast=\"auto\">,<\/span><span data-contrast=\"auto\">\u00a05<\/span><span data-contrast=\"auto\">5<\/span><span data-contrast=\"auto\">% required ICU admission, 49% required invasive mechanical venti<\/span><span data-contrast=\"auto\">l<\/span><span data-contrast=\"auto\">ation, and 1<\/span><span data-contrast=\"auto\">3<\/span><span data-contrast=\"auto\">% died<\/span><span data-contrast=\"auto\">.<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">The<\/span><span data-contrast=\"auto\">\u00a0investigators\u00a0<\/span><span data-contrast=\"auto\">evaluated\u00a0<\/span><span data-contrast=\"auto\">response to tocilizumab using multiple<\/span><span data-contrast=\"auto\">\u00a0methods<\/span><span data-contrast=\"auto\">\u00a0and found that the response defined<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">by<\/span><span data-contrast=\"auto\">\u00a0stable or decreasing scores on the\u00a0<\/span><span data-contrast=\"auto\">Lower Brescia COVID Respiratory Severity Scale\u00a0<\/span><span data-contrast=\"auto\">was associated with lower odds of mortality (OR=<\/span><span data-contrast=\"auto\">0.1<\/span><span data-contrast=\"auto\">4, 95% CI 0.03\u00a0<\/span><span data-contrast=\"auto\">\u2013<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">0.74), while<\/span><span data-contrast=\"auto\">\u00a0response defined by other methods was not associated with mortality<\/span><span data-contrast=\"auto\">.\u00a0<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Moreno-P\u00e9rez et al. (July 16, 2020). Experience with Tocilizumab in Severe COVID-19 Pneumonia after 80 Days of Follow-up: A Retrospective Cohort Study. Journal of Autoimmunity.\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.1016\/j.jaut.2020.102523\"><span data-contrast=\"none\">https:\/\/doi.org\/10.1016\/j.jaut.2020.102523<\/span><\/a><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<\/p>\n<\/div>\n<p>\t\t\t\t\t\t\t\t\t<!-- <a href=\"\" class=\"su-post-comments-link\"><\/a> --><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"js-accordion__panel\" >\n<h2 class=\"js-accordion__header\"><span class=\"TextRun SCXW22351167 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW22351167 BCX0\" data-ccp-parastyle=\"heading 2\">Clinical Characteristics<\/span><\/span><span class=\"TextRun SCXW22351167 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW22351167 BCX0\" data-ccp-parastyle=\"heading 2\"> and Health Care Setting<\/span><\/span><\/h2>\n<div class=\"su-posts su-posts-default-loop\">\n<div id=\"su-post-8393\" class=\"su-post\">\n<h5 class=\"su-post-title\">SARS-CoV-2 in Pregnancy: Characteristics and Outcomes of Hospitalized and Non-Hospitalized Women Due to COVID-19<\/h5>\n<p>\t\t\t\t<!-- \n\n\n\n\n\n\n\n\n\n\n\n<div class=\"su-post-meta\">\n\t\t\t\t\t: \t\t\t\t<\/div>\n\n\n\n\n\n\n\n\n\n\n\n --><\/p>\n<div class=\"su-post-excerpt\">\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"47\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"auto\">Barbero et al. report findings from a\u00a0<\/span><span data-contrast=\"auto\">retrospective cohort study\u00a0<\/span><span data-contrast=\"auto\">of all\u00a0<\/span><span data-contrast=\"auto\">women diagnosed with SARS-CoV-2 infection during pregnancy or\u00a0<\/span><span data-contrast=\"auto\">the\u00a0<\/span><span data-contrast=\"auto\">postpartum period<\/span><span data-contrast=\"auto\">\u00a0(n=91) in a\u00a0<\/span><span data-contrast=\"auto\">tertiary care center<\/span><span data-contrast=\"auto\">\u00a0in Spain. COVID-19 symptoms were the presenting complaint in 6<\/span><span data-contrast=\"auto\">2<\/span><span data-contrast=\"auto\">% of patients. Forty patients\u00a0<\/span><span data-contrast=\"auto\">(44%)\u00a0<\/span><span data-contrast=\"auto\">developed pneumonia, 46% were hospitalized, and 4 required ICU admission,\u00a0<\/span><span data-contrast=\"auto\">which was\u00a0<\/span><span data-contrast=\"auto\">double the hospitalization (15.8-21.9%) and ICU admission (1.3-2.2%) rate for non-pregnant female patients of the same age in Spain.\u00a0<\/span><span data-contrast=\"auto\">The r<\/span><span data-contrast=\"auto\">ate of cesarean section was more than three times higher\u00a0<\/span><span data-contrast=\"auto\">among women<\/span><span data-contrast=\"auto\">\u00a0hospitalized\u00a0<\/span><span data-contrast=\"auto\">due to<\/span><span data-contrast=\"auto\">\u00a0COVID-19 (8<\/span><span data-contrast=\"auto\">2<\/span><span data-contrast=\"auto\">%) than\u00a0<\/span><span data-contrast=\"auto\">women who were\u00a0<\/span><span data-contrast=\"auto\">hospitalized for other reasons (25%).\u00a0<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Barbero et al. (July 20, 2020). SARS-CoV-2 in Pregnancy: Characteristics and Outcomes of Hospitalized and Non-Hospitalized Women Due to COVID-19. The Journal of Maternal-Fetal &amp; Neonatal Medicine.\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.1080\/14767058.2020.1793320\"><i><span data-contrast=\"none\">https:\/\/doi.org\/10.1080\/14767058.2020.1793320<\/span><\/i><\/a><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<\/p>\n<\/div>\n<p>\t\t\t\t\t\t\t\t\t<!-- <a href=\"\" class=\"su-post-comments-link\"><\/a> --><\/p>\n<\/div>\n<div id=\"su-post-8391\" class=\"su-post\">\n<h5 class=\"su-post-title\">Symptom Clusters in Covid19\u00a0A\u00a0Potential Clinical Prediction Tool from the COVID Symptom Study App<\/h5>\n<p>\t\t\t\t<!-- \n\n\n\n\n\n\n\n\n\n\n\n<div class=\"su-post-meta\">\n\t\t\t\t\t: \t\t\t\t<\/div>\n\n\n\n\n\n\n\n\n\n\n\n --><\/p>\n<div class=\"su-post-excerpt\">\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"43\" data-aria-posinset=\"2\" data-aria-level=\"1\"><i><span data-contrast=\"none\">[pre-print, not peer-reviewed]<\/span><\/i><span data-contrast=\"none\">\u00a0<\/span><span data-contrast=\"auto\">Sudre\u00a0<\/span><span data-contrast=\"auto\">et al.\u00a0<\/span><span data-contrast=\"auto\">present data<\/span><span data-contrast=\"auto\">\u00a0from\u00a0<\/span><span data-contrast=\"auto\">1,653<\/span><span data-contrast=\"auto\">\u00a0individuals\u00a0<\/span><span data-contrast=\"auto\">who had confirmed COVID-19 and regularly logged their symptoms<\/span><span data-contrast=\"auto\">\u00a0using the\u00a0<\/span><span data-contrast=\"auto\">COVID Symptom Study app<\/span><span data-contrast=\"auto\">, which was developed by the King\u2019s College London and ZOE<\/span><span data-contrast=\"auto\">. Their analysis\u00a0<\/span><span data-contrast=\"auto\">classified<\/span><span data-contrast=\"auto\">\u00a0six distinct types of COVID-1<\/span><span data-contrast=\"auto\">9<\/span><span data-contrast=\"auto\">\u00a0distinguished by clusters of symptoms and\u00a0<\/span><span data-contrast=\"auto\">used\u00a0<\/span><span data-contrast=\"auto\">type to predict the need for respiratory support<\/span><span data-contrast=\"auto\">.\u00a0<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:240}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"43\" data-aria-posinset=\"3\" data-aria-level=\"1\"><span data-contrast=\"auto\">Wise\u00a0<\/span><span data-contrast=\"auto\">published<\/span><span data-contrast=\"auto\">\u00a0a summary and interpretation of this study.\u00a0<\/span><a href=\"https:\/\/doi.org\/10.1136\/bmj.m2911\"><i><span data-contrast=\"none\">https:\/\/doi.org\/10.1136\/bmj.m2911<\/span><\/i><\/a><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:240}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Sudre\u00a0et al. (June 16, 2020). Symptom Clusters in Covid19\u00a0A\u00a0Potential Clinical Prediction Tool from the COVID Symptom Study App.\u00a0<\/span><\/i><i><span data-contrast=\"none\">Pre-print downloaded July 21 from<\/span><\/i><i><span data-contrast=\"none\">\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.1101\/2020.06.12.20129056\"><span data-contrast=\"none\">https:\/\/doi.org\/10.1101\/2020.06.12.20129056<\/span><\/a><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:240}\">\u00a0<\/span><\/p>\n<\/p>\n<\/div>\n<p>\t\t\t\t\t\t\t\t\t<!-- <a href=\"\" class=\"su-post-comments-link\"><\/a> --><\/p>\n<\/div>\n<div id=\"su-post-8389\" class=\"su-post\">\n<h5 class=\"su-post-title\">Neutralizing and Binding Antibody Kinetics of COVID-19 Patients during Hospital and Convalescent Phases<\/h5>\n<p>\t\t\t\t<!-- \n\n\n\n\n\n\n\n\n\n\n\n<div class=\"su-post-meta\">\n\t\t\t\t\t: \t\t\t\t<\/div>\n\n\n\n\n\n\n\n\n\n\n\n --><\/p>\n<div class=\"su-post-excerpt\">\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"43\" data-aria-posinset=\"1\" data-aria-level=\"1\"><i><span data-contrast=\"none\">[pre-print, not peer-reviewed]<\/span><\/i><span data-contrast=\"none\">\u00a0<\/span><span data-contrast=\"auto\">Yao et al. analyzed antibody kinetics\u00a0<\/span><span data-contrast=\"auto\">using\u00a0<\/span><span data-contrast=\"auto\">244 serial blood samples\u00a0<\/span><span data-contrast=\"auto\">from\u00a0<\/span><span data-contrast=\"auto\">34\u00a0<\/span><span data-contrast=\"auto\">people with\u00a0<\/span><span data-contrast=\"auto\">COVID-19.<\/span><span data-contrast=\"auto\">\u00a0All types of antibodies measured\u00a0<\/span><span data-contrast=\"auto\">were detected\u00a0<\/span><span data-contrast=\"auto\">approximately two weeks after\u00a0illness\u00a0onset.<\/span><span data-contrast=\"auto\">\u00a0Based on estimated half<\/span><span data-contrast=\"auto\">&#8211;<\/span><span data-contrast=\"auto\">li<\/span><span data-contrast=\"auto\">fe<\/span><span data-contrast=\"auto\">,\u00a0<\/span><span data-contrast=\"auto\">the authors\u00a0<\/span><span data-contrast=\"auto\">estimated median times to\u00a0seronegativity\u00a0following disease onset to be 4.6 months for IgM (IQR 4.1-5.0), 7.8 months for IgA (IQR 6.7-9.2), and 43 months (IQR 34-48) for IgG<\/span><span data-contrast=\"auto\">.<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">Neutralizing<\/span><span data-contrast=\"auto\">\u00a0antibod<\/span><span data-contrast=\"auto\">i<\/span><span data-contrast=\"auto\">es (Nab) declined faster than IgG but slower than IgM<\/span><span data-contrast=\"auto\">.<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">T<\/span><span data-contrast=\"auto\">he\u00a0<\/span><span data-contrast=\"auto\">relative<\/span><span data-contrast=\"auto\">\u00a0contribution of IgM to Nab was higher than that of IgG.\u00a0<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Yao et al. (July 21, 2020). Neutralizing and Binding Antibody Kinetics of COVID-19 Patients during Hospital and Convalescent Phases.\u00a0<\/span><\/i><i><span data-contrast=\"none\">Pre-print\u00a0downloaded July 21 from<\/span><\/i><i><span data-contrast=\"none\">\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.1101\/2020.07.18.20156810\"><span data-contrast=\"none\">https:\/\/doi.org\/10.1101\/2020.07.18.20156810<\/span><\/a><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<\/p>\n<\/div>\n<p>\t\t\t\t\t\t\t\t\t<!-- <a href=\"\" class=\"su-post-comments-link\"><\/a> --><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"js-accordion__panel\" >\n<h2 class=\"js-accordion__header\"><span class=\"TextRun SCXW82890009 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW82890009 BCX0\" data-ccp-parastyle=\"heading 2\">Mode<\/span><\/span><span class=\"TextRun SCXW82890009 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW82890009 BCX0\" data-ccp-parastyle=\"heading 2\">ling and Prediction<\/span><\/span><\/h2>\n<div class=\"su-posts su-posts-default-loop\">\n<div id=\"su-post-8395\" class=\"su-post\">\n<h5 class=\"su-post-title\">Bidirectional Impact of Imperfect Mask Use on Reproduction Number of COVID-19: A next Generation Matrix Approach<\/h5>\n<p>\t\t\t\t<!-- \n\n\n\n\n\n\n\n\n\n\n\n<div class=\"su-post-meta\">\n\t\t\t\t\t: \t\t\t\t<\/div>\n\n\n\n\n\n\n\n\n\n\n\n --><\/p>\n<div class=\"su-post-excerpt\">\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"43\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"auto\">Using a next generation matrix approach, Fisman et al. found that even modest use of imperfect masks\u00a0reduce\u00a0COVID-19 transmission, and widespread use may be able to bring R<\/span><span data-contrast=\"auto\">0<\/span><span data-contrast=\"auto\">&lt;1 if it has already been brought close to 1 by other interventions. However, the effect of mask wearing on transmission at a population level is reduced in scenarios in which mask wearers are more likely to mix with\u00a0<\/span><span data-contrast=\"auto\">other\u00a0<\/span><span data-contrast=\"auto\">mask wearers than\u00a0<\/span><span data-contrast=\"auto\">with\u00a0<\/span><span data-contrast=\"auto\">non-wearers (assortativ<\/span><span data-contrast=\"auto\">e<\/span><span data-contrast=\"auto\">\u00a0mixing).\u00a0<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Fisman et al. (2020). Bidirectional Impact of Imperfect Mask Use on Reproduction Number of COVID-19: A next Generation Matrix Approach. Infectious Disease Modelling.\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.1016\/j.idm.2020.06.004\"><span data-contrast=\"none\">https:\/\/doi.org\/10.1016\/j.idm.2020.06.004<\/span><\/a><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<\/p>\n<\/div>\n<p>\t\t\t\t\t\t\t\t\t<!-- <a href=\"\" class=\"su-post-comments-link\"><\/a> --><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"js-accordion__panel\" >\n<h2 class=\"js-accordion__header\"><span class=\"TextRun SCXW256833614 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW256833614 BCX0\" data-ccp-parastyle=\"heading 2\">Public Health Policy and Practice<\/span><\/span><\/h2>\n<div class=\"su-posts su-posts-default-loop\">\n<div id=\"su-post-8399\" class=\"su-post\">\n<h5 class=\"su-post-title\">Mitigation of a COVID-19 Outbreak in a Nursing Home Through Serial Testing of Residents and Staff<\/h5>\n<p>\t\t\t\t<!-- \n\n\n\n\n\n\n\n\n\n\n\n<div class=\"su-post-meta\">\n\t\t\t\t\t: \t\t\t\t<\/div>\n\n\n\n\n\n\n\n\n\n\n\n --><\/p>\n<div class=\"su-post-excerpt\">\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"43\" data-aria-posinset=\"2\" data-aria-level=\"1\"><span data-contrast=\"auto\">Escobar et al.\u00a0<\/span><span data-contrast=\"auto\">report on an outbreak in\u00a0<\/span><span data-contrast=\"auto\">a Pennsylvania\u00a0<\/span><span data-contrast=\"auto\">nursing home\u00a0<\/span><span data-contrast=\"auto\">with 84 residents (83 male, mean age 74)<\/span><span data-contrast=\"auto\">.\u00a0<\/span><span data-contrast=\"auto\">The index resident tested positive after exposure to a positive\u00a0<\/span><span data-contrast=\"auto\">e<\/span><span data-contrast=\"auto\">mployee<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">who had not\u00a0<\/span><span data-contrast=\"auto\">yet developed symptoms<\/span><span data-contrast=\"auto\">.\u00a0\u00a0<\/span><span data-contrast=\"auto\">I<\/span><span data-contrast=\"auto\">nterventions<\/span><span data-contrast=\"auto\">\u00a0implemented<\/span><span data-contrast=\"auto\">\u00a0includ<\/span><span data-contrast=\"auto\">ed<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">a dedicated isolation unit,\u00a0<\/span><span data-contrast=\"auto\">restrictions on resident travel, universal masking of residents, addition of eye shields to\u00a0<\/span><span data-contrast=\"auto\">PPE mandated for staff<\/span><span data-contrast=\"auto\">, and serial testing of residents every 3-5 days.\u00a0<\/span><span data-contrast=\"auto\">Twenty-seven\u00a0<\/span><span data-contrast=\"auto\">residents<\/span><span data-contrast=\"auto\">\u00a0tested positive<\/span><span data-contrast=\"auto\">\u00a0(26 from the index resident\u2019s floor),\u00a0<\/span><span data-contrast=\"auto\">representing an attack rate of 37<\/span><span data-contrast=\"auto\">%, and 13\u00a0<\/span><span data-contrast=\"auto\">residents\u00a0<\/span><span data-contrast=\"auto\">developed symptoms<\/span><span data-contrast=\"auto\">.\u00a0<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Escobar et al. (July 20, 2020). Mitigation of a COVID-19 Outbreak in a Nursing Home Through Serial Testing of Residents and Staff. Clinical Infectious Diseases.\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.1093\/cid\/ciaa1021\"><span data-contrast=\"none\">https:\/\/doi.org\/10.1093\/cid\/ciaa1021<\/span><\/a><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<\/p>\n<\/div>\n<p>\t\t\t\t\t\t\t\t\t<!-- <a href=\"\" class=\"su-post-comments-link\"><\/a> --><\/p>\n<\/div>\n<div id=\"su-post-8397\" class=\"su-post\">\n<h5 class=\"su-post-title\">Lessons from Mass-Testing for COVID-19 in Long Term Care Facilities for the Elderly in San Francisco<\/h5>\n<p>\t\t\t\t<!-- \n\n\n\n\n\n\n\n\n\n\n\n<div class=\"su-post-meta\">\n\t\t\t\t\t: \t\t\t\t<\/div>\n\n\n\n\n\n\n\n\n\n\n\n --><\/p>\n<div class=\"su-post-excerpt\">\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"43\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"auto\">Louie et al. describe the results of surveillance, outbreak response, and control measures to prevent COVID-19 in 4 long term care facilities (LCTF) in San Francisco early in the pandemic. Facility-wide testing of asymptomatic health care workers (HCWs) and residents in these 4 facilities (n=303) found 16% of HCWs and 40% of residents were positive. Across facilities, the proportion of COVID-19 cases who were asymptomatic ranged from 4% to 41% among HCWs and 20% to 75% among residents. Despite temperature and symptom surveillance before each shift, out of the 4 HCWs identified as the index case for outbreaks, 3 reported working while symptomatic, all of whom wore masks but not necessarily eye protection, gloves, or gowns.\u00a0<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Louie et al. (July 20, 2020). Lessons from Mass-Testing for COVID-19 in Long Term Care Facilities for the Elderly in San Francisco. Clinical Infectious Diseases.\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.1093\/cid\/ciaa1020\"><span data-contrast=\"none\">https:\/\/doi.org\/10.1093\/cid\/ciaa1020<\/span><\/a><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<\/p>\n<\/div>\n<p>\t\t\t\t\t\t\t\t\t<!-- <a href=\"\" class=\"su-post-comments-link\"><\/a> --><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<h3><strong>Other Resources and Commentaries<\/strong><\/h3>\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"49\" data-aria-posinset=\"1\" data-aria-level=\"1\"><a href=\"https:\/\/doi.org\/10.1101\/2020.07.18.20156901\"><span data-contrast=\"none\">Detecting Emerging COVID-19 Community Outbreaks at High Spatiotemporal Resolution &#8211; New York City June 2020<\/span><\/a><span data-contrast=\"auto\">\u00a0\u2013\u00a0<\/span><span data-contrast=\"auto\">medRxiv<\/span><span data-contrast=\"auto\">\u00a0(July 21)\u00a0<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559685&quot;:360,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"49\" data-aria-posinset=\"2\" data-aria-level=\"1\"><a href=\"https:\/\/doi.org\/10.1016\/j.jpeds.2020.07.042\"><span data-contrast=\"none\">Child Care in the Time of COVID-19: A Period of Challenge and Opportunity<\/span><\/a><span data-contrast=\"auto\">\u00a0\u2013 The Journal of Pediatrics (July\u00a0<\/span><span data-contrast=\"auto\">17<\/span><span data-contrast=\"auto\">)\u00a0<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559685&quot;:360,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"49\" data-aria-posinset=\"3\" data-aria-level=\"1\"><a href=\"https:\/\/doi.org\/10.1016\/j.eclinm.2020.100467\"><span data-contrast=\"none\">Tocilizumab Improves Survival in Patients with Persistent Hypoxia in Severe COVID-19 Pneumonia<\/span><\/a><span data-contrast=\"auto\">\u00a0\u2013\u00a0EClinicalMedicine\u00a0(July 7)\u00a0<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559685&quot;:360,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"49\" data-aria-posinset=\"1\" data-aria-level=\"1\"><a href=\"https:\/\/doi.org\/10.1016\/j.jstrokecerebrovasdis.2020.104953\"><span data-contrast=\"none\">Falling Stroke Rates during COVID-19 Pandemic at a Comprehensive Stroke Center<\/span><\/a><span data-contrast=\"auto\">\u00a0\u2013 Journal of Stroke and Cerebrovascular\u00a0Diseases\u202f:\u00a0The Official Journal of\u00a0National\u00a0Stroke Association (Aug)\u00a0<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559685&quot;:360,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"49\" data-aria-posinset=\"2\" data-aria-level=\"1\"><a href=\"https:\/\/doi.org\/10.1001\/jamapediatrics.2020.2810\"><span data-contrast=\"none\">Should Coronavirus Disease 2019\u2013Associated Inflammatory Syndromes in Children Affect Social Reintegration?<\/span><\/a><span data-contrast=\"auto\">\u00a0\u2013 JAMA Pediatrics (July 20)\u00a0<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559685&quot;:360,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"49\" data-aria-posinset=\"3\" data-aria-level=\"1\"><a href=\"https:\/\/doi.org\/10.1016\/j.scitotenv.2020.140946\"><span data-contrast=\"none\">SARS-CoV-2 in the Environment: Modes of Transmission, Early Detection and Potential Role of Pollutions<\/span><\/a><span data-contrast=\"auto\">\u00a0\u2013 Science of The Total Environment (<\/span><span data-contrast=\"auto\">July 15<\/span><span data-contrast=\"auto\">)\u00a0<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559685&quot;:360,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"49\" data-aria-posinset=\"4\" data-aria-level=\"1\"><a href=\"https:\/\/doi.org\/10.1016\/S0140-6736(20)31611-1\"><span data-contrast=\"none\">Encouraging Results from Phase 1\/2 COVID-19 Vaccine Trials<\/span><\/a><span data-contrast=\"auto\">\u00a0\u2013 The Lancet (July\u00a0<\/span><span data-contrast=\"auto\">20<\/span><span data-contrast=\"auto\">)\u00a0<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559685&quot;:360,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"49\" data-aria-posinset=\"5\" data-aria-level=\"1\"><a href=\"https:\/\/doi.org\/10.1038\/s41390-020-1067-3\"><span data-contrast=\"none\">Inclusion of Children and Pregnant Women in COVID-19 Intervention Trials<\/span><\/a><span data-contrast=\"auto\">\u00a0\u2013 Pediatric Research\u00a0<\/span><br \/>\n<span data-contrast=\"auto\">(July 20)\u00a0<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559685&quot;:360,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"49\" data-aria-posinset=\"1\" data-aria-level=\"1\"><a href=\"https:\/\/doi.org\/10.1177\/2150132720943331\"><span data-contrast=\"none\">Rigorous Hand Hygiene Practices Among Health Care Workers Reduce Hospital-Associated Infections During the COVID-19 Pandemic<\/span><\/a><span data-contrast=\"auto\">\u00a0\u2013 Journal of Primary Care &amp; Community\u00a0Health\u00a0<\/span><span data-contrast=\"auto\">\u00a0(July 19)<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559685&quot;:360,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>A seroprevalence study in Blaine County, Idaho, a resort community with a high incidence of COVID-19 in March and April, found nearly a quarter of residents were positive for SARS-CoV-2 antibodies. <\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/07\/21\/lessons-from-mass-testing-for-covid-19-in-long-term-care-facilities-for-the-elderly-in-san-francisco\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":334,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[5],"tags":[],"topic":[],"class_list":["post-8367","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-covid-19-literature-situation-report"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/8367","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=8367"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/8367\/revisions"}],"predecessor-version":[{"id":8401,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/8367\/revisions\/8401"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media\/334"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=8367"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=8367"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=8367"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=8367"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}