{"id":8389,"date":"2020-07-21T15:56:58","date_gmt":"2020-07-21T22:56:58","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=8389"},"modified":"2021-04-02T15:57:39","modified_gmt":"2021-04-02T22:57:39","slug":"neutralizing-and-binding-antibody-kinetics-of-covid-19-patients-during-hospital-and-convalescent-phases","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/07\/21\/neutralizing-and-binding-antibody-kinetics-of-covid-19-patients-during-hospital-and-convalescent-phases\/","title":{"rendered":"Neutralizing and Binding Antibody Kinetics of COVID-19 Patients during Hospital and Convalescent Phases"},"content":{"rendered":"<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"43\" data-aria-posinset=\"1\" data-aria-level=\"1\"><i><span data-contrast=\"none\">[pre-print, not peer-reviewed]<\/span><\/i><span data-contrast=\"none\">\u00a0<\/span><span data-contrast=\"auto\">Yao et al. analyzed antibody kinetics\u00a0<\/span><span data-contrast=\"auto\">using\u00a0<\/span><span data-contrast=\"auto\">244 serial blood samples\u00a0<\/span><span data-contrast=\"auto\">from\u00a0<\/span><span data-contrast=\"auto\">34\u00a0<\/span><span data-contrast=\"auto\">people with\u00a0<\/span><span data-contrast=\"auto\">COVID-19.<\/span><span data-contrast=\"auto\">\u00a0All types of antibodies measured\u00a0<\/span><span data-contrast=\"auto\">were detected\u00a0<\/span><span data-contrast=\"auto\">approximately two weeks after\u00a0illness\u00a0onset.<\/span><span data-contrast=\"auto\">\u00a0Based on estimated half<\/span><span data-contrast=\"auto\">&#8211;<\/span><span data-contrast=\"auto\">li<\/span><span data-contrast=\"auto\">fe<\/span><span data-contrast=\"auto\">,\u00a0<\/span><span data-contrast=\"auto\">the authors\u00a0<\/span><span data-contrast=\"auto\">estimated median times to\u00a0seronegativity\u00a0following disease onset to be 4.6 months for IgM (IQR 4.1-5.0), 7.8 months for IgA (IQR 6.7-9.2), and 43 months (IQR 34-48) for IgG<\/span><span data-contrast=\"auto\">.<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">Neutralizing<\/span><span data-contrast=\"auto\">\u00a0antibod<\/span><span data-contrast=\"auto\">i<\/span><span data-contrast=\"auto\">es (Nab) declined faster than IgG but slower than IgM<\/span><span data-contrast=\"auto\">.<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">T<\/span><span data-contrast=\"auto\">he\u00a0<\/span><span data-contrast=\"auto\">relative<\/span><span data-contrast=\"auto\">\u00a0contribution of IgM to Nab was higher than that of IgG.\u00a0<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Yao et al. (July 21, 2020). Neutralizing and Binding Antibody Kinetics of COVID-19 Patients during Hospital and Convalescent Phases.\u00a0<\/span><\/i><i><span data-contrast=\"none\">Pre-print\u00a0downloaded July 21 from<\/span><\/i><i><span data-contrast=\"none\">\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.1101\/2020.07.18.20156810\"><span data-contrast=\"none\">https:\/\/doi.org\/10.1101\/2020.07.18.20156810<\/span><\/a><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>[pre-print, not peer-reviewed]\u00a0Yao et al. analyzed antibody kinetics\u00a0using\u00a0244 serial blood samples\u00a0from\u00a034\u00a0people with\u00a0COVID-19.\u00a0All types of antibodies measured\u00a0were detected\u00a0approximately two weeks after\u00a0illness\u00a0onset.\u00a0Based on estimated half&#8211;life,\u00a0the authors\u00a0estimated median times to\u00a0seronegativity\u00a0following disease onset to be 4.6 months for IgM (IQR 4.1-5.0), 7.8 months for IgA (IQR 6.7-9.2), and 43 months (IQR 34-48) for IgG.\u00a0Neutralizing\u00a0antibodies (Nab) declined faster than IgG&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/07\/21\/neutralizing-and-binding-antibody-kinetics-of-covid-19-patients-during-hospital-and-convalescent-phases\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[],"topic":[20],"class_list":["post-8389","post","type-post","status-publish","format-standard","hentry","category-article-summary","topic-clinical-characteristics-and-health-care-setting"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/8389","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=8389"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/8389\/revisions"}],"predecessor-version":[{"id":8390,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/8389\/revisions\/8390"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=8389"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=8389"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=8389"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=8389"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}