{"id":8435,"date":"2020-07-23T16:37:40","date_gmt":"2020-07-23T23:37:40","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=8435"},"modified":"2021-04-02T16:38:18","modified_gmt":"2021-04-02T23:38:18","slug":"tracking-changes-in-sars-cov-2-spike-evidence-that-d614g-increases-infectivity-of-the-covid-19-virus","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/07\/23\/tracking-changes-in-sars-cov-2-spike-evidence-that-d614g-increases-infectivity-of-the-covid-19-virus\/","title":{"rendered":"Tracking Changes in SARS-CoV-2 Spike: Evidence That D614G Increases Infectivity of the COVID-19 Virus"},"content":{"rendered":"<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"34\" data-aria-posinset=\"2019\" data-aria-level=\"1\"><span data-contrast=\"auto\">Korber et al. present evidence\u00a0<\/span><span data-contrast=\"auto\">that\u00a0<\/span><span data-contrast=\"auto\">SARS-CoV-2 viruses\u00a0<\/span><span data-contrast=\"auto\">with<\/span><span data-contrast=\"auto\">\u00a0the<\/span><span data-contrast=\"auto\">\u00a0G614\u00a0<\/span><span data-contrast=\"auto\">mutation in\u00a0<\/span><span data-contrast=\"auto\">the Spike protein\u00a0<\/span><span data-contrast=\"auto\">are<\/span><span data-contrast=\"auto\">\u00a0more prev<\/span><span data-contrast=\"auto\">ale<\/span><span data-contrast=\"auto\">nt tha<\/span><span data-contrast=\"auto\">n<\/span><span data-contrast=\"auto\">\u00a0the original\u00a0<\/span><span data-contrast=\"auto\">D614 form identified\u00a0<\/span><span data-contrast=\"auto\">in<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">the first human cases in Wuhan, China.\u00a0<\/span><span data-contrast=\"auto\">In a f<\/span><span data-contrast=\"auto\">ollow-up stud<\/span><span data-contrast=\"auto\">y\u00a0<\/span><span data-contrast=\"auto\">of<\/span><span data-contrast=\"auto\">\u00a0999<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">COVID-19 patients at the Sheffield Teaching Hospitals<\/span><span data-contrast=\"auto\">,<\/span><span data-contrast=\"auto\">\u00a0patients infected with G614 shed more viral nucleic acid compared with those with D614 (p=0.037), and G614-viruses show significantly higher infectious titers in vitro than their D614 counterparts<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">(2.6- to 9.3-fold increase, p&lt;0.0001).<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Korber et al. (August 20, 2020). Tracking Changes in SARS-CoV-2 Spike: Evidence That D614G Increases Infectivity of the COVID-19 Virus. Cell.\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.1016\/j.cell.2020.06.043\"><span data-contrast=\"none\">https:\/\/doi.org\/10.1016\/j.cell.2020.06.043<\/span><\/a><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Korber et al. present evidence\u00a0that\u00a0SARS-CoV-2 viruses\u00a0with\u00a0the\u00a0G614\u00a0mutation in\u00a0the Spike protein\u00a0are\u00a0more prevalent than\u00a0the original\u00a0D614 form identified\u00a0in\u00a0the first human cases in Wuhan, China.\u00a0In a follow-up study\u00a0of\u00a0999\u00a0COVID-19 patients at the Sheffield Teaching Hospitals,\u00a0patients infected with G614 shed more viral nucleic acid compared with those with D614 (p=0.037), and G614-viruses show significantly higher infectious titers in vitro than their D614&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/07\/23\/tracking-changes-in-sars-cov-2-spike-evidence-that-d614g-increases-infectivity-of-the-covid-19-virus\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[],"topic":[21],"class_list":["post-8435","post","type-post","status-publish","format-standard","hentry","category-article-summary","topic-transmission"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/8435","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=8435"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/8435\/revisions"}],"predecessor-version":[{"id":8436,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/8435\/revisions\/8436"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=8435"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=8435"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=8435"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=8435"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}