{"id":8441,"date":"2020-07-23T16:40:28","date_gmt":"2020-07-23T23:40:28","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=8441"},"modified":"2021-04-02T16:41:06","modified_gmt":"2021-04-02T23:41:06","slug":"chloroquine-does-not-inhibit-infection-of-human-lung-cells-with-sars-cov-2","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/07\/23\/chloroquine-does-not-inhibit-infection-of-human-lung-cells-with-sars-cov-2\/","title":{"rendered":"Chloroquine\u00a0Does Not Inhibit\u00a0Infection\u00a0of Human Lung Cells with SARS-CoV-2"},"content":{"rendered":"<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"34\" data-aria-posinset=\"2019\" data-aria-level=\"1\"><span data-contrast=\"auto\">TMPRSS2<\/span><span data-contrast=\"auto\">\u00a0is\u00a0<\/span><span data-contrast=\"auto\">a cellular protease\u00a0<\/span><span data-contrast=\"auto\">gene<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">that activates SARS-CoV-2 for entry into lung cells<\/span><span data-contrast=\"auto\">. Hoffmann et al. report<\/span><span data-contrast=\"auto\">\u00a0that<\/span><span data-contrast=\"auto\">\u00a0the engineered expression of TMPRSS2\u00a0<\/span><span data-contrast=\"auto\">in\u00a0<\/span><i><span data-contrast=\"auto\">ex-vivo<\/span><\/i><span data-contrast=\"auto\">\u00a0Vero cell<\/span><span data-contrast=\"auto\">s<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">render<\/span><span data-contrast=\"auto\">s<\/span><span data-contrast=\"auto\">\u00a0SARS-CoV-2 infection insensitive to chloroquine. Moreover, chloroquine d<\/span><span data-contrast=\"auto\">id<\/span><span data-contrast=\"auto\">\u00a0not block SARS-CoV-2 infection\u00a0<\/span><span data-contrast=\"auto\">in<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">TMPRSS2-positive lung cell<\/span><span data-contrast=\"auto\">s<\/span><span data-contrast=\"auto\">. The<\/span><span data-contrast=\"auto\">\u00a0authors conclude\u00a0<\/span><span data-contrast=\"auto\">results indicate that chloroquine targets a pathway for viral activation that is not operative in lung cells and is unlikely to protect against SARS-CoV-2 spread in and between patients.<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Hoffmann et al. (July 22, 2020).\u00a0Chloroquine\u00a0Does Not Inhibit\u00a0Infection\u00a0of Human Lung Cells with SARS-CoV-2. Nature.\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.1038\/s41586-020-2575-3\"><span data-contrast=\"none\">https:\/\/doi.org\/10.1038\/s41586-020-2575-3<\/span><\/a><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>TMPRSS2\u00a0is\u00a0a cellular protease\u00a0gene\u00a0that activates SARS-CoV-2 for entry into lung cells. Hoffmann et al. report\u00a0that\u00a0the engineered expression of TMPRSS2\u00a0in\u00a0ex-vivo\u00a0Vero cells\u00a0renders\u00a0SARS-CoV-2 infection insensitive to chloroquine. Moreover, chloroquine did\u00a0not block SARS-CoV-2 infection\u00a0in\u00a0TMPRSS2-positive lung cells. The\u00a0authors conclude\u00a0results indicate that chloroquine targets a pathway for viral activation that is not operative in lung cells and is unlikely to protect against&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/07\/23\/chloroquine-does-not-inhibit-infection-of-human-lung-cells-with-sars-cov-2\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[],"topic":[19],"class_list":["post-8441","post","type-post","status-publish","format-standard","hentry","category-article-summary","topic-testing-and-treatment"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/8441","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=8441"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/8441\/revisions"}],"predecessor-version":[{"id":8442,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/8441\/revisions\/8442"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=8441"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=8441"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=8441"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=8441"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}