{"id":8443,"date":"2020-07-23T16:41:17","date_gmt":"2020-07-23T23:41:17","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=8443"},"modified":"2021-04-02T16:41:58","modified_gmt":"2021-04-02T23:41:58","slug":"historically-controlled-comparison-of-glucocorticoids-with-or-without-tocilizumab-versus-supportive-care-only-in-patients-with-covid-19-associated-cytokine-storm-syndrome-results-of-the-chic-study","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/07\/23\/historically-controlled-comparison-of-glucocorticoids-with-or-without-tocilizumab-versus-supportive-care-only-in-patients-with-covid-19-associated-cytokine-storm-syndrome-results-of-the-chic-study\/","title":{"rendered":"Historically Controlled Comparison of Glucocorticoids with or without Tocilizumab versus Supportive Care Only in Patients with COVID-19-Associated Cytokine Storm Syndrome: Results of the CHIC Study"},"content":{"rendered":"<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"34\" data-aria-posinset=\"2019\" data-aria-level=\"1\"><span data-contrast=\"auto\">Ramiro et al<\/span><span data-contrast=\"auto\">. evaluated clinical records of\u00a0<\/span><span data-contrast=\"auto\">86 patients with severe COVID-19-associated cytokine storm syndrome who received an intensive course of glucocorticoids<\/span><span data-contrast=\"auto\">.<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">Compared\u00a0<\/span><span data-contrast=\"auto\">to\u00a0<\/span><span data-contrast=\"auto\">an untreated historical\u00a0<\/span><span data-contrast=\"auto\">group<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">of patients who received supportive care only<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">(1:1 match on sex and age)<\/span><span data-contrast=\"auto\">, treated patients had\u00a0<\/span><span data-contrast=\"auto\">a\u00a0<\/span><span data-contrast=\"auto\">higher\u00a0<\/span><span data-contrast=\"auto\">rate of reaching<\/span><span data-contrast=\"auto\">\u00a0respiratory recovery (<\/span><span data-contrast=\"auto\">HR<\/span><span data-contrast=\"auto\">=<\/span><span data-contrast=\"auto\">1.8<\/span><span data-contrast=\"auto\">)<\/span><span data-contrast=\"auto\">,\u00a0<\/span><span data-contrast=\"auto\">were less likely to die\u00a0<\/span><span data-contrast=\"auto\">(<\/span><span data-contrast=\"auto\">HR=<\/span><span data-contrast=\"auto\">0.35<\/span><span data-contrast=\"auto\">)<\/span><span data-contrast=\"auto\">,<\/span><span data-contrast=\"auto\">\u00a0and\u00a0<\/span><span data-contrast=\"auto\">had a lower rate of\u00a0<\/span><span data-contrast=\"auto\">invasive mechanical ventilation (<\/span><span data-contrast=\"auto\">HR=<\/span><span data-contrast=\"auto\">0.29<\/span><span data-contrast=\"auto\">).<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Ramiro et al. (July 20, 2020). Historically Controlled Comparison of Glucocorticoids with or without Tocilizumab versus Supportive Care Only in Patients with COVID-19-Associated Cytokine Storm Syndrome: Results of the CHIC Study. Annals of\u00a0the Rheumatic\u00a0Diseases.\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.1136\/annrheumdis-2020-218479\"><span data-contrast=\"none\">https:\/\/doi.org\/10.1136\/annrheumdis-2020-218479<\/span><\/a><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Ramiro et al. evaluated clinical records of\u00a086 patients with severe COVID-19-associated cytokine storm syndrome who received an intensive course of glucocorticoids.\u00a0Compared\u00a0to\u00a0an untreated historical\u00a0group\u00a0of patients who received supportive care only\u00a0(1:1 match on sex and age), treated patients had\u00a0a\u00a0higher\u00a0rate of reaching\u00a0respiratory recovery (HR=1.8),\u00a0were less likely to die\u00a0(HR=0.35),\u00a0and\u00a0had a lower rate of\u00a0invasive mechanical ventilation (HR=0.29).\u00a0 Ramiro et al&#8230;.<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/07\/23\/historically-controlled-comparison-of-glucocorticoids-with-or-without-tocilizumab-versus-supportive-care-only-in-patients-with-covid-19-associated-cytokine-storm-syndrome-results-of-the-chic-study\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[],"topic":[19],"class_list":["post-8443","post","type-post","status-publish","format-standard","hentry","category-article-summary","topic-testing-and-treatment"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/8443","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=8443"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/8443\/revisions"}],"predecessor-version":[{"id":8444,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/8443\/revisions\/8444"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=8443"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=8443"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=8443"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=8443"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}