{"id":8455,"date":"2020-07-23T16:46:40","date_gmt":"2020-07-23T23:46:40","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=8455"},"modified":"2021-04-02T16:47:22","modified_gmt":"2021-04-02T23:47:22","slug":"potent-neutralizing-antibodies-directed-to-multiple-epitopes-on-sars-cov-2-spike","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/07\/23\/potent-neutralizing-antibodies-directed-to-multiple-epitopes-on-sars-cov-2-spike\/","title":{"rendered":"Potent Neutralizing Antibodies Directed to Multiple Epitopes on SARS-CoV-2 Spike"},"content":{"rendered":"<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"34\" data-aria-posinset=\"2019\" data-aria-level=\"1\"><span data-contrast=\"auto\">A large number of\u00a0monoclonal antibodies that potently neutralize the SARS-CoV-2 virus were identified from COVID-19 cases from New York. Liu et al. report the isolation of 61 SARS-CoV-2-neutralizing monoclonal antibodies from 5 infected patients hospitalized with severe disease<\/span><span data-contrast=\"auto\">\u00a0at the Columbia University Irving Medical Center in New York City<\/span><span data-contrast=\"auto\">. Among these are 19 antibodies that potently neutralized the authentic SARS-CoV-2 virus\u00a0<\/span><i><span data-contrast=\"auto\">in vitro<\/span><\/i><span data-contrast=\"auto\">, 9 of which exhibited exquisite potency. Epitope mapping\u00a0show\u00a0these antibodies are directed to the top of the viral spike, which the authors say indicates immunogenicity. Several of these monoclonal antibodies are promising candidates for clinical development as potential therapeutic and\/or prophylactic agents against SARS-CoV-2.<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Liu et al. (July 22, 2020). Potent Neutralizing Antibodies Directed to Multiple Epitopes on SARS-CoV-2 Spike. Nature.\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.1038\/s41586-020-2571-7\"><span data-contrast=\"none\">https:\/\/doi.org\/10.1038\/s41586-020-2571-7<\/span><\/a><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A large number of\u00a0monoclonal antibodies that potently neutralize the SARS-CoV-2 virus were identified from COVID-19 cases from New York. Liu et al. report the isolation of 61 SARS-CoV-2-neutralizing monoclonal antibodies from 5 infected patients hospitalized with severe disease\u00a0at the Columbia University Irving Medical Center in New York City. Among these are 19 antibodies that potently&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/07\/23\/potent-neutralizing-antibodies-directed-to-multiple-epitopes-on-sars-cov-2-spike\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[],"topic":[31],"class_list":["post-8455","post","type-post","status-publish","format-standard","hentry","category-article-summary","topic-vaccines-and-immunity"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/8455","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=8455"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/8455\/revisions"}],"predecessor-version":[{"id":8456,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/8455\/revisions\/8456"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=8455"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=8455"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=8455"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=8455"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}