{"id":8457,"date":"2020-07-23T16:47:34","date_gmt":"2020-07-23T23:47:34","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=8457"},"modified":"2021-04-02T16:48:17","modified_gmt":"2021-04-02T23:48:17","slug":"kinetics-and-isotype-assessment-of-antibodies-targeting-the-spike-protein-receptor-binding-domain-of-sars-cov-2-in-covid-19-patients-as-a-function-of-age-and-biological-sex","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/07\/23\/kinetics-and-isotype-assessment-of-antibodies-targeting-the-spike-protein-receptor-binding-domain-of-sars-cov-2-in-covid-19-patients-as-a-function-of-age-and-biological-sex\/","title":{"rendered":"Kinetics and Isotype Assessment of Antibodies Targeting the Spike Protein Receptor Binding Domain of SARS-CoV-2 In COVID-19 Patients as a Function of Age and Biological Sex"},"content":{"rendered":"<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"34\" data-aria-posinset=\"2019\" data-aria-level=\"1\"><i><span data-contrast=\"none\">[Preprint, not peer reviewed]\u00a0<\/span><\/i><span data-contrast=\"auto\">The<\/span><span data-contrast=\"auto\">\u00a0receptor-binding domain of the\u00a0CoV\u00a0spike (RBD-S) protein is important in host cell recognition and infection, and antibodies targeting this domain are often neutralizing.<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">Graham<\/span><span data-contrast=\"auto\">\u00a0et al.\u00a0<\/span><span data-contrast=\"auto\">tested anti-RBD-S responses among 32 COVID-19 patients. They found that IgG, IgM, and IgA responses were all induced within 10 days following symptom onset, and IgG response was sustained over a 5-week period. No differences in responses were observed by age or sex, indicating that age-and sex-<\/span><span data-contrast=\"auto\">related disparities in COVID-19\u00a0<\/span><span data-contrast=\"auto\">fatality are not explained by<\/span><span data-contrast=\"auto\">\u00a0anti-RBD-S responses.<\/span><span data-contrast=\"auto\">\u00a0The authors concluded that the multi-isotype anti-RBD-S response could serve as a potential marker by which to monitor vaccine-induced responses.<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Graham et al. (July 22, 2020). Kinetics and Isotype Assessment of Antibodies Targeting the Spike Protein Receptor Binding Domain of SARS-CoV-2 In COVID-19 Patients as a Function of Age and Biological Sex. Pre-print\u00a0downloaded July 23 from\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.1101\/2020.07.15.20154443\"><span data-contrast=\"none\">https:\/\/doi.org\/10.1101\/2020.07.15.20154443<\/span><\/a><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>[Preprint, not peer reviewed]\u00a0The\u00a0receptor-binding domain of the\u00a0CoV\u00a0spike (RBD-S) protein is important in host cell recognition and infection, and antibodies targeting this domain are often neutralizing.\u00a0Graham\u00a0et al.\u00a0tested anti-RBD-S responses among 32 COVID-19 patients. They found that IgG, IgM, and IgA responses were all induced within 10 days following symptom onset, and IgG response was sustained over&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/07\/23\/kinetics-and-isotype-assessment-of-antibodies-targeting-the-spike-protein-receptor-binding-domain-of-sars-cov-2-in-covid-19-patients-as-a-function-of-age-and-biological-sex\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[],"topic":[31],"class_list":["post-8457","post","type-post","status-publish","format-standard","hentry","category-article-summary","topic-vaccines-and-immunity"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/8457","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=8457"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/8457\/revisions"}],"predecessor-version":[{"id":8458,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/8457\/revisions\/8458"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=8457"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=8457"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=8457"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=8457"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}