{"id":8470,"date":"2020-07-24T10:02:51","date_gmt":"2020-07-24T17:02:51","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=8470"},"modified":"2021-04-05T10:03:47","modified_gmt":"2021-04-05T17:03:47","slug":"convalescent-plasma-treatment-for-sars-cov-2-infection-analysis-of-the-first-436-donors-in-england-22-april-to-12-may-2020","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/07\/24\/convalescent-plasma-treatment-for-sars-cov-2-infection-analysis-of-the-first-436-donors-in-england-22-april-to-12-may-2020\/","title":{"rendered":"Convalescent Plasma Treatment for SARS-CoV-2 Infection: Analysis of the First 436 Donors in England, 22 April to 12 May 2020"},"content":{"rendered":"<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"43\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"auto\">Among 436\u00a0<\/span><span data-contrast=\"auto\">convalescent plasma donations collected from individuals with confirmed\u00a0<\/span><span data-contrast=\"auto\">(59%)\u00a0<\/span><span data-contrast=\"auto\">or suspected\u00a0<\/span><span data-contrast=\"auto\">(41%)\u00a0<\/span><span data-contrast=\"auto\">SARS-CoV-2<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">infection\u00a0<\/span><span data-contrast=\"auto\">by the UK National Health Service<\/span><span data-contrast=\"auto\">\u00a0at least 30 days\u00a0<\/span><span data-contrast=\"auto\">after diagnosis<\/span><span data-contrast=\"auto\">,<\/span><span data-contrast=\"auto\">\u00a08<\/span><span data-contrast=\"auto\">7<\/span><span data-contrast=\"auto\">% were positive for IgG antibodies<\/span><span data-contrast=\"auto\">\u00a0and 7<\/span><span data-contrast=\"auto\">6<\/span><span data-contrast=\"auto\">% were positive for neutralizing antibodies<\/span><span data-contrast=\"auto\">.\u00a0<\/span><span data-contrast=\"auto\">Among those with\u00a0<\/span><span data-contrast=\"auto\">confirmed SARS-CoV-2, 99%<\/span><span data-contrast=\"auto\">\u00a0had IgG antibodies and\u00a0<\/span><span data-contrast=\"auto\">88%<\/span><span data-contrast=\"auto\">\u00a0had neutralizing antibodies<\/span><span data-contrast=\"auto\">.<\/span><span data-contrast=\"auto\">\u00a0Neutralizing antibody titers were high enough to be used for treatment of other SARS-CoV-2 patients in 34% of donations, with the\u00a0<\/span><span data-contrast=\"auto\">higher levels associated with confirmed infection, prior hospitalization, older age, and more recent diagnosis.<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">Antibody levels decline<\/span><span data-contrast=\"auto\">d<\/span><span data-contrast=\"auto\">\u00a0over three months following diagnosis.\u00a0<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Harvala et al. (July 2020). Convalescent Plasma Treatment for SARS-CoV-2 Infection: Analysis of the First 436 Donors in England, 22 April to 12 May 2020. Euro Surveillance.\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.2807\/1560-7917.ES.2020.25.28.2001260\"><span data-contrast=\"none\">https:\/\/doi.org\/10.2807\/1560-7917.ES.2020.25.28.2001260<\/span><\/a><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Among 436\u00a0convalescent plasma donations collected from individuals with confirmed\u00a0(59%)\u00a0or suspected\u00a0(41%)\u00a0SARS-CoV-2\u00a0infection\u00a0by the UK National Health Service\u00a0at least 30 days\u00a0after diagnosis,\u00a087% were positive for IgG antibodies\u00a0and 76% were positive for neutralizing antibodies.\u00a0Among those with\u00a0confirmed SARS-CoV-2, 99%\u00a0had IgG antibodies and\u00a088%\u00a0had neutralizing antibodies.\u00a0Neutralizing antibody titers were high enough to be used for treatment of other SARS-CoV-2 patients in 34%&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/07\/24\/convalescent-plasma-treatment-for-sars-cov-2-infection-analysis-of-the-first-436-donors-in-england-22-april-to-12-may-2020\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[],"topic":[19],"class_list":["post-8470","post","type-post","status-publish","format-standard","hentry","category-article-summary","topic-testing-and-treatment"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/8470","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=8470"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/8470\/revisions"}],"predecessor-version":[{"id":8471,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/8470\/revisions\/8471"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=8470"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=8470"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=8470"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=8470"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}