{"id":8480,"date":"2020-07-24T10:09:41","date_gmt":"2020-07-24T17:09:41","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=8480"},"modified":"2021-04-05T10:11:03","modified_gmt":"2021-04-05T17:11:03","slug":"presence-of-genetic-variants-among-young-men-with-severe-covid-19","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/07\/24\/presence-of-genetic-variants-among-young-men-with-severe-covid-19\/","title":{"rendered":"Presence of Genetic Variants Among Young Men\u00a0With\u00a0Severe COVID-19."},"content":{"rendered":"<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"43\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"auto\">A rare genetic mutation was identified in two\u00a0sets of brothers\u00a0who had severe COVID-19 disease. A case series reported by van der Made et al. included two sets of brothers under age 35 (mean age 26) without pre-existing medical conditions who were hospitalized with severe COVID-19 in the Netherlands. All four men required mechanical ventilation in the\u00a0ICU\u00a0and one died. Whole-exome sequencing and basic genetic and immunological tests identified a loss-of-function X-chromosomal\u00a0<\/span><i><span data-contrast=\"auto\">TLR7<\/span><\/i><span data-contrast=\"auto\">\u00a0gene variant that is associated with impaired type I and II interferon responses.\u00a0\u00a0<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:240}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">van der Made et al. (2020). Presence of Genetic Variants Among Young Men\u00a0With\u00a0Severe COVID-19<\/span><\/i><i><span data-contrast=\"none\">. JAMA<\/span><\/i><i><span data-contrast=\"none\">.\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.1001\/jama.2020.13719\"><span data-contrast=\"none\">https:\/\/doi.org\/10.1001\/jama.2020.13719<\/span><\/a><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A rare genetic mutation was identified in two\u00a0sets of brothers\u00a0who had severe COVID-19 disease. A case series reported by van der Made et al. included two sets of brothers under age 35 (mean age 26) without pre-existing medical conditions who were hospitalized with severe COVID-19 in the Netherlands. All four men required mechanical ventilation in&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/07\/24\/presence-of-genetic-variants-among-young-men-with-severe-covid-19\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_members_access_role":[],"_members_access_error":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[],"topic":[20],"class_list":["post-8480","post","type-post","status-publish","format-standard","hentry","category-article-summary","topic-clinical-characteristics-and-health-care-setting"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/8480","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=8480"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/8480\/revisions"}],"predecessor-version":[{"id":8481,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/8480\/revisions\/8481"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=8480"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=8480"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=8480"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=8480"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}