{"id":8498,"date":"2020-07-27T10:26:04","date_gmt":"2020-07-27T17:26:04","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=8498"},"modified":"2021-04-05T10:26:46","modified_gmt":"2021-04-05T17:26:46","slug":"hydroxychloroquine-with-or-without-azithromycin-in-mild-to-moderate-covid-19","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/07\/27\/hydroxychloroquine-with-or-without-azithromycin-in-mild-to-moderate-covid-19\/","title":{"rendered":"Hydroxychloroquine with or without Azithromycin in Mild-to-Moderate Covid-19"},"content":{"rendered":"<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"34\" data-aria-posinset=\"2019\" data-aria-level=\"1\"><span data-contrast=\"auto\">A randomized trial of hydroxychloroquine, alone or with a<\/span><span data-contrast=\"auto\">zithromycin<\/span><span data-contrast=\"auto\">,<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">for treatment of mild- to moderate COVID-19 found no effect on\u00a0<\/span><span data-contrast=\"auto\">improving clinical status at 15 days after hospital admission<\/span><span data-contrast=\"auto\">.\u00a0<\/span><span data-contrast=\"auto\">Cavalcanti et al. conducted a<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">multicenter, randomized, open-label, three-<\/span><span data-contrast=\"auto\">arm<\/span><span data-contrast=\"auto\">\u00a0controlled trial (n=504)<\/span><span data-contrast=\"auto\">\u00a0in Brazil<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">and\u00a0<\/span><span data-contrast=\"auto\">found that the odds of having a higher score<\/span><span data-contrast=\"auto\">\u00a0(worse clinical status)<\/span><span data-contrast=\"auto\">\u00a0on\u00a0<\/span><span data-contrast=\"auto\">a\u00a0<\/span><span data-contrast=\"auto\">7-point ordinal scale at 15 days was not affe<\/span><span data-contrast=\"auto\">cted<\/span><span data-contrast=\"auto\">\u00a0by\u00a0<\/span><span data-contrast=\"auto\">hydroxychloroquine\u00a0<\/span><span data-contrast=\"auto\">alone (OR=1.21, 95% CI 0.69-2.11),<\/span><span data-contrast=\"auto\">\u00a0or hydroxychloroquine<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">and<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">a<\/span><span data-contrast=\"auto\">zithromycin (OR=0.99, 95% CI 0.57-1.73)<\/span><span data-contrast=\"auto\">, compared to standard care<\/span><span data-contrast=\"auto\">.<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Cavalcanti et al. (July 23, 2020). Hydroxychloroquine with or without Azithromycin in Mild-to-Moderate Covid-19. New England Journal of Medicine.\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.1056\/NEJMoa2019014\"><span data-contrast=\"none\">https:\/\/doi.org\/10.1056\/NEJMoa2019014<\/span><\/a><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A randomized trial of hydroxychloroquine, alone or with azithromycin,\u00a0for treatment of mild- to moderate COVID-19 found no effect on\u00a0improving clinical status at 15 days after hospital admission.\u00a0Cavalcanti et al. conducted a\u00a0multicenter, randomized, open-label, three-arm\u00a0controlled trial (n=504)\u00a0in Brazil\u00a0and\u00a0found that the odds of having a higher score\u00a0(worse clinical status)\u00a0on\u00a0a\u00a07-point ordinal scale at 15 days was not affected\u00a0by\u00a0hydroxychloroquine\u00a0alone&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/07\/27\/hydroxychloroquine-with-or-without-azithromycin-in-mild-to-moderate-covid-19\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[],"topic":[19],"class_list":["post-8498","post","type-post","status-publish","format-standard","hentry","category-article-summary","topic-testing-and-treatment"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/8498","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=8498"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/8498\/revisions"}],"predecessor-version":[{"id":8499,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/8498\/revisions\/8499"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=8498"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=8498"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=8498"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=8498"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}