{"id":8504,"date":"2020-07-27T10:28:53","date_gmt":"2020-07-27T17:28:53","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=8504"},"modified":"2021-04-05T10:29:34","modified_gmt":"2021-04-05T17:29:34","slug":"retrospective-multicenter-cohort-study-shows-early-interferon-therapy-is-associated-with-favorable-clinical-responses-in-covid-19-patients","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/07\/27\/retrospective-multicenter-cohort-study-shows-early-interferon-therapy-is-associated-with-favorable-clinical-responses-in-covid-19-patients\/","title":{"rendered":"Retrospective Multicenter Cohort Study Shows Early Interferon Therapy Is Associated with Favorable Clinical Responses in COVID-19 Patients"},"content":{"rendered":"<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"34\" data-aria-posinset=\"2019\" data-aria-level=\"1\"><span data-contrast=\"auto\">Based on a\u00a0<\/span><span data-contrast=\"auto\">retrospective cohort study of COVID-19 patients in Hubei, China (n=446)<\/span><span data-contrast=\"auto\">,<\/span><span data-contrast=\"auto\">\u00a0early administration of interferon-a2b was associated with\u00a0<\/span><span data-contrast=\"auto\">lower likelihood of<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">in-hospital mortality\u00a0<\/span><span data-contrast=\"auto\">versus no interferon\u00a0<\/span><span data-contrast=\"auto\">(OR=0.05, 95% CI: 0.01-0.37)<\/span><span data-contrast=\"auto\">,<\/span><span data-contrast=\"auto\">\u00a0while late interferon therapy\u00a0<\/span><span data-contrast=\"auto\">was associated with greater likelihood\u00a0<\/span><span data-contrast=\"auto\">of mortality (OR=6.82, 95% CI: 1.14-40.8)<\/span><span data-contrast=\"auto\">. This may indicate that\u00a0<\/span><span data-contrast=\"auto\">the timing for interferon therapy may be\u00a0<\/span><span data-contrast=\"auto\">important<\/span><span data-contrast=\"auto\">.<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">Most<\/span><span data-contrast=\"auto\">\u00a0of the patients in the study who received interferon also received\u00a0<\/span><span data-contrast=\"auto\">the antiviral<\/span><span data-contrast=\"auto\">\u00a0agents\u00a0<\/span><span data-contrast=\"auto\">umifenovir\u00a0or\u00a0<\/span><span data-contrast=\"auto\">lopinavir boosted with ritonavir<\/span><span data-contrast=\"auto\">.<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Wang et al. (July 18, 2020). Retrospective Multicenter Cohort Study Shows Early Interferon Therapy Is Associated with Favorable Clinical Responses in COVID-19 Patients. Cell Host &amp; Microbe.\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.1016\/j.chom.2020.07.005\"><span data-contrast=\"none\">https:\/\/doi.org\/10.1016\/j.chom.2020.07.005<\/span><\/a><i><span data-contrast=\"none\">\u00a0<\/span><\/i><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Based on a\u00a0retrospective cohort study of COVID-19 patients in Hubei, China (n=446),\u00a0early administration of interferon-a2b was associated with\u00a0lower likelihood of\u00a0in-hospital mortality\u00a0versus no interferon\u00a0(OR=0.05, 95% CI: 0.01-0.37),\u00a0while late interferon therapy\u00a0was associated with greater likelihood\u00a0of mortality (OR=6.82, 95% CI: 1.14-40.8). This may indicate that\u00a0the timing for interferon therapy may be\u00a0important.\u00a0Most\u00a0of the patients in the study who received&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/07\/27\/retrospective-multicenter-cohort-study-shows-early-interferon-therapy-is-associated-with-favorable-clinical-responses-in-covid-19-patients\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[],"topic":[19],"class_list":["post-8504","post","type-post","status-publish","format-standard","hentry","category-article-summary","topic-testing-and-treatment"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/8504","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=8504"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/8504\/revisions"}],"predecessor-version":[{"id":8505,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/8504\/revisions\/8505"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=8504"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=8504"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=8504"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=8504"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}