{"id":8506,"date":"2020-07-27T10:29:44","date_gmt":"2020-07-27T17:29:44","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=8506"},"modified":"2021-04-05T10:30:28","modified_gmt":"2021-04-05T17:30:28","slug":"sars-cov-2-igg-response-is-different-in-covid-19-outpatients-and-asymptomatic-contact-persons","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/07\/27\/sars-cov-2-igg-response-is-different-in-covid-19-outpatients-and-asymptomatic-contact-persons\/","title":{"rendered":"SARS-CoV-2-IgG Response Is Different in COVID-19 Outpatients and Asymptomatic Contact Persons"},"content":{"rendered":"<ul>\n<li><span data-contrast=\"auto\">Wellinghausen<\/span><span data-contrast=\"auto\">\u00a0et al. conducted\u00a0<\/span><span data-contrast=\"auto\">a\u00a0<\/span><span data-contrast=\"auto\">retrospective analysis of serum samples (n=158) from a German cohort of PCR confirmed COVID-19 outpatients and asymptomatic contact persons (n=158) and found that overall positivity rate for SARS-CoV-2-IgG was 81% among outpatients and 15% among asymptomatic contact<\/span><span data-contrast=\"auto\">s<\/span><span data-contrast=\"auto\">.<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"34\" data-aria-posinset=\"2019\" data-aria-level=\"1\"><span data-contrast=\"auto\">Symptomatic outpatients had a higher viral load, based on PCR cycle counts, compared to\u00a0<\/span><span data-contrast=\"auto\">asymptomatic contact<\/span><span data-contrast=\"auto\">s (5-7\u00a0<\/span><span data-contrast=\"auto\">threshold cycles<\/span><span data-contrast=\"auto\">)<\/span><span data-contrast=\"auto\">.<\/span><span data-contrast=\"auto\">\u00a0Viral load was also positively correlated with\u00a0<\/span><span data-contrast=\"auto\">SARS-<\/span><span data-contrast=\"auto\">CoV-2-IgG<\/span><span data-contrast=\"auto\">\u00a0ratio. The authors hypothesize that the lower viral load in asymptomatic cases could explain the lower\u00a0sero-prevalence in those without symptoms.<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Wellinghausen\u00a0et al. (July 6, 2020). SARS-CoV-2-IgG Response Is Different in COVID-19 Outpatients and Asymptomatic Contact Persons. Journal of Clinical Virology.\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.1016\/j.jcv.2020.104542\"><span data-contrast=\"none\">https:\/\/doi.org\/10.1016\/j.jcv.2020.104542<\/span><\/a><i><span data-contrast=\"none\">\u00a0<\/span><\/i><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Wellinghausen\u00a0et al. conducted\u00a0a\u00a0retrospective analysis of serum samples (n=158) from a German cohort of PCR confirmed COVID-19 outpatients and asymptomatic contact persons (n=158) and found that overall positivity rate for SARS-CoV-2-IgG was 81% among outpatients and 15% among asymptomatic contacts.\u00a0 Symptomatic outpatients had a higher viral load, based on PCR cycle counts, compared to\u00a0asymptomatic contacts (5-7\u00a0threshold&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/07\/27\/sars-cov-2-igg-response-is-different-in-covid-19-outpatients-and-asymptomatic-contact-persons\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[],"topic":[19],"class_list":["post-8506","post","type-post","status-publish","format-standard","hentry","category-article-summary","topic-testing-and-treatment"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/8506","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=8506"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/8506\/revisions"}],"predecessor-version":[{"id":8507,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/8506\/revisions\/8507"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=8506"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=8506"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=8506"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=8506"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}