{"id":8531,"date":"2020-07-28T10:43:10","date_gmt":"2020-07-28T17:43:10","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=8531"},"modified":"2021-04-05T10:44:00","modified_gmt":"2021-04-05T17:44:00","slug":"evolution-of-viral-quasispecies-during-sars-cov-2-infection","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/07\/28\/evolution-of-viral-quasispecies-during-sars-cov-2-infection\/","title":{"rendered":"Evolution of Viral\u00a0Quasispecies\u00a0during\u00a0SARS-CoV-2 Infection"},"content":{"rendered":"<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"48\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"auto\">Jary et al report on\u00a0<\/span><span data-contrast=\"auto\">the genomic diversity of SARS-CoV-2 in longitudinal samples (n=7) collected from a\u00a0<\/span><span data-contrast=\"auto\">single\u00a0<\/span><span data-contrast=\"auto\">patient in\u00a0<\/span><span data-contrast=\"auto\">Paris\u00a0<\/span><span data-contrast=\"auto\">with mild symptoms\u00a0<\/span><span data-contrast=\"auto\">early\u00a0in the course of\u00a0the COVID-19 pandemic.\u00a0<\/span><span data-contrast=\"auto\">Majority consensus\u00a0<\/span><span data-contrast=\"auto\">sequences\u00a0<\/span><span data-contrast=\"auto\">were identical in five out of seven samples<\/span><span data-contrast=\"auto\">, differing from the Wuhan reference sequence by one synonymous mutation.\u00a0<\/span><span data-contrast=\"auto\">Over two hundred<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">minority\u00a0<\/span><span data-contrast=\"auto\">variants\u00a0<\/span><span data-contrast=\"auto\">were detected (median of 38 per sample), with four variants shared by different samples<\/span><span data-contrast=\"auto\">.\u00a0<\/span><span data-contrast=\"auto\">Over half\u00a0<\/span><span data-contrast=\"auto\">of mutations had\u00a0moderate\u00a0or high impact on gene expression, and variants differed between lower and upper respiratory tract samples collected on the same day.<\/span><span data-contrast=\"auto\">\u00a0The authors suggest t<\/span><span data-contrast=\"auto\">hese results\u00a0<\/span><span data-contrast=\"auto\">provide evidence of\u00a0<\/span><span data-contrast=\"auto\">SARS-CoV-2\u00a0quasispecies\u00a0<\/span><span data-contrast=\"auto\">that\u00a0<\/span><span data-contrast=\"auto\">vary day-to-day and between anatomical sites.<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Jary et al. (July 2020). Evolution of Viral\u00a0Quasispecies\u00a0during\u00a0SARS-CoV-2 Infection. Clinical Microbiology and Infection.\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.1016\/j.cmi.2020.07.032\"><span data-contrast=\"none\">https:\/\/doi.org\/10.1016\/j.cmi.2020.07.032<\/span><\/a><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Jary et al report on\u00a0the genomic diversity of SARS-CoV-2 in longitudinal samples (n=7) collected from a\u00a0single\u00a0patient in\u00a0Paris\u00a0with mild symptoms\u00a0early\u00a0in the course of\u00a0the COVID-19 pandemic.\u00a0Majority consensus\u00a0sequences\u00a0were identical in five out of seven samples, differing from the Wuhan reference sequence by one synonymous mutation.\u00a0Over two hundred\u00a0minority\u00a0variants\u00a0were detected (median of 38 per sample), with four variants shared by&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/07\/28\/evolution-of-viral-quasispecies-during-sars-cov-2-infection\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[],"topic":[20],"class_list":["post-8531","post","type-post","status-publish","format-standard","hentry","category-article-summary","topic-clinical-characteristics-and-health-care-setting"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/8531","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=8531"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/8531\/revisions"}],"predecessor-version":[{"id":8532,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/8531\/revisions\/8532"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=8531"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=8531"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=8531"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=8531"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}