{"id":8537,"date":"2020-07-28T10:45:54","date_gmt":"2020-07-28T17:45:54","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=8537"},"modified":"2021-04-05T10:46:59","modified_gmt":"2021-04-05T17:46:59","slug":"characteristics-and-strength-of-evidence-of-covid-19-studies-registered-on-clinicaltrials-gov","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/07\/28\/characteristics-and-strength-of-evidence-of-covid-19-studies-registered-on-clinicaltrials-gov\/","title":{"rendered":"Characteristics and Strength of Evidence of COVID-19 Studies Registered on\u00a0ClinicalTrials.Gov"},"content":{"rendered":"<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"49\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"auto\">An assessment of COVID-19-related studies registered on ClinicalTrials.gov found that only 29% would have the potential to result in the highest level of individual study evidence (Oxford Centre for Evidence [OCEBM] level 2).\u00a0<\/span><span data-contrast=\"auto\">Pundi\u00a0et al. report on\u00a0<\/span><span data-contrast=\"auto\">COVID-19<\/span><span data-contrast=\"auto\">&#8211;<\/span><span data-contrast=\"auto\">related studies<\/span><span data-contrast=\"auto\">\u00a0registered on ClinicalTrials.gov as<\/span><span data-contrast=\"auto\">\u00a0of\u00a0<\/span><span data-contrast=\"auto\">May 19, 2020, excluding withdrawn, suspended, terminated, or expanded-access studies<\/span><span data-contrast=\"auto\">\u00a0(n=1,551 studies, 911 interventional).\u00a0<\/span><span data-contrast=\"auto\">P<\/span><span data-contrast=\"auto\">rimary outcome pertained to clinical course, including mortality (33%), ventilation requirement (2<\/span><span data-contrast=\"auto\">7<\/span><span data-contrast=\"auto\">%), and treatment complications (23%).\u00a0<\/span><span data-contrast=\"auto\">Of the 664 RCTs, blinding was reported for 55%, placebo control for 29%, planned enrollment of more than 100 participants for 3<\/span><span data-contrast=\"auto\">6<\/span><span data-contrast=\"auto\">%, and two or more study centers for 17%.\u00a0<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Pundi\u00a0et al. (July 27, 2020). Characteristics and Strength of Evidence of COVID-19 Studies Registered on\u00a0ClinicalTrials.Gov. JAMA Internal Medicine.\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.1001\/jamainternmed.2020.2904\"><span data-contrast=\"none\">https:\/\/doi.org\/10.1001\/jamainternmed.2020.2904<\/span><\/a><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>An assessment of COVID-19-related studies registered on ClinicalTrials.gov found that only 29% would have the potential to result in the highest level of individual study evidence (Oxford Centre for Evidence [OCEBM] level 2).\u00a0Pundi\u00a0et al. report on\u00a0COVID-19&#8211;related studies\u00a0registered on ClinicalTrials.gov as\u00a0of\u00a0May 19, 2020, excluding withdrawn, suspended, terminated, or expanded-access studies\u00a0(n=1,551 studies, 911 interventional).\u00a0Primary outcome pertained to&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/07\/28\/characteristics-and-strength-of-evidence-of-covid-19-studies-registered-on-clinicaltrials-gov\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[],"topic":[16],"class_list":["post-8537","post","type-post","status-publish","format-standard","hentry","category-article-summary","topic-public-health-policy-and-practice"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/8537","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=8537"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/8537\/revisions"}],"predecessor-version":[{"id":8538,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/8537\/revisions\/8538"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=8537"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=8537"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=8537"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=8537"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}