{"id":8551,"date":"2020-07-29T10:57:25","date_gmt":"2020-07-29T17:57:25","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=8551"},"modified":"2021-04-05T10:58:09","modified_gmt":"2021-04-05T17:58:09","slug":"evaluation-of-the-mrna-1273-vaccine-against-sars-cov-2-in-nonhuman-primates","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/07\/29\/evaluation-of-the-mrna-1273-vaccine-against-sars-cov-2-in-nonhuman-primates\/","title":{"rendered":"Evaluation of the MRNA-1273 Vaccine against SARS-CoV-2 in Nonhuman Primates"},"content":{"rendered":"<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"34\" data-aria-posinset=\"2019\" data-aria-level=\"1\"><span data-contrast=\"auto\">Corbett et al.<\/span><span data-contrast=\"auto\">\u00a0report that vaccination of\u00a0<\/span><span data-contrast=\"auto\">Indian-origin rhesus macaques with mRNA-1273,<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">a vaccine candidate encoding the prefusion-stabilized spike protein of SARS-CoV-2, induced robust antibody and T-cell responses before challenge with SARS-CoV-2<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">in upper- and lower-airway. Following exposure of the animals to infectious doses of SARS-CoV-2 there was indication of rapid protection from infection and no pathologic changes in the lungs of the animals.\u00a0<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Corbett et al. (July 28, 2020). Evaluation of the MRNA-1273 Vaccine against SARS-CoV-2 in Nonhuman Primates. New England Journal of Medicine.\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.1056\/NEJMoa2024671\"><span data-contrast=\"none\">https:\/\/doi.org\/10.1056\/NEJMoa2024671<\/span><\/a><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Corbett et al.\u00a0report that vaccination of\u00a0Indian-origin rhesus macaques with mRNA-1273,\u00a0a vaccine candidate encoding the prefusion-stabilized spike protein of SARS-CoV-2, induced robust antibody and T-cell responses before challenge with SARS-CoV-2\u00a0in upper- and lower-airway. Following exposure of the animals to infectious doses of SARS-CoV-2 there was indication of rapid protection from infection and no pathologic changes in&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/07\/29\/evaluation-of-the-mrna-1273-vaccine-against-sars-cov-2-in-nonhuman-primates\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[],"topic":[31],"class_list":["post-8551","post","type-post","status-publish","format-standard","hentry","category-article-summary","topic-vaccines-and-immunity"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/8551","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=8551"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/8551\/revisions"}],"predecessor-version":[{"id":8552,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/8551\/revisions\/8552"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=8551"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=8551"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=8551"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=8551"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}