{"id":8559,"date":"2020-07-29T11:01:17","date_gmt":"2020-07-29T18:01:17","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=8559"},"modified":"2021-04-05T11:02:03","modified_gmt":"2021-04-05T18:02:03","slug":"ace2-expression-is-elevated-in-airway-epithelial-cells-from-aged-and-male-donors-but-reduced-in-asthma","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/07\/29\/ace2-expression-is-elevated-in-airway-epithelial-cells-from-aged-and-male-donors-but-reduced-in-asthma\/","title":{"rendered":"ACE2 Expression Is Elevated in Airway Epithelial Cells from Aged and Male Donors but Reduced in Asthma"},"content":{"rendered":"<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"34\" data-aria-posinset=\"2019\" data-aria-level=\"1\"><i><span data-contrast=\"none\">[pre-print, not peer-reviewed]<\/span><\/i><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">Wark et al.\u00a0<\/span><span data-contrast=\"auto\">examined risk factors associated with ACE2 expression in 145 patients with asthma and chronic obstructive pulmonary disease (COPD) in Australia. They found\u00a0<\/span><span data-contrast=\"auto\">that\u00a0<\/span><span data-contrast=\"auto\">older age and male sex\u00a0<\/span><span data-contrast=\"auto\">were\u00a0<\/span><span data-contrast=\"auto\">associated with<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">increased ACE2 expression, and asthma was associated with reduced expression.\u00a0<\/span><span data-contrast=\"auto\">The authors\u00a0<\/span><span data-contrast=\"auto\">concluded that a<\/span><span data-contrast=\"auto\">ltered ACE2 expression in the lower airway may be an important factor in\u00a0<\/span><span data-contrast=\"auto\">SARS-CoV-2\u00a0<\/span><span data-contrast=\"auto\">virus tropism and may<\/span><span data-contrast=\"auto\">,<\/span><span data-contrast=\"auto\">\u00a0in part<\/span><span data-contrast=\"auto\">,<\/span><span data-contrast=\"auto\">\u00a0explain why\u00a0<\/span><span data-contrast=\"auto\">patients with\u00a0<\/span><span data-contrast=\"auto\">asthma\u00a0<\/span><span data-contrast=\"auto\">do not appear to be\u00a0<\/span><span data-contrast=\"auto\">overrepresented in those with COVID-19 complications.<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Wark et al. (July 29, 2020). ACE2 Expression Is Elevated in Airway Epithelial Cells from Aged and Male Donors but Reduced in Asthma. Pre-print\u00a0downloaded July 29 from\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.1101\/2020.07.26.20162248\"><span data-contrast=\"none\">https:\/\/doi.org\/10.1101\/2020.07.26.20162248<\/span><\/a><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>[pre-print, not peer-reviewed]\u00a0Wark et al.\u00a0examined risk factors associated with ACE2 expression in 145 patients with asthma and chronic obstructive pulmonary disease (COPD) in Australia. They found\u00a0that\u00a0older age and male sex\u00a0were\u00a0associated with\u00a0increased ACE2 expression, and asthma was associated with reduced expression.\u00a0The authors\u00a0concluded that altered ACE2 expression in the lower airway may be an important factor in\u00a0SARS-CoV-2\u00a0virus&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/07\/29\/ace2-expression-is-elevated-in-airway-epithelial-cells-from-aged-and-male-donors-but-reduced-in-asthma\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[],"topic":[20],"class_list":["post-8559","post","type-post","status-publish","format-standard","hentry","category-article-summary","topic-clinical-characteristics-and-health-care-setting"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/8559","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=8559"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/8559\/revisions"}],"predecessor-version":[{"id":8560,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/8559\/revisions\/8560"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=8559"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=8559"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=8559"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=8559"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}