The scientific literature on COVID-19 is rapidly evolving and these articles were selected for review based on their relevance to Washington State decision making around COVID-19 response efforts. Included in these Lit Reps are some manuscripts that have been made available online as pre-prints but have not yet undergone peer review. Please be aware of this when reviewing articles included in the Lit Reps.<\/p>\n
Today’s summary is based on a review of\u00a0218 articles (199 published, 19 in preprint).<\/em><\/p>\n \t\t\t\t<\/p>\n \u2022 [Pre-print, not peer reviewed] A study utilizing Danish registry data found that the proportion of contacts of an initial index case with SARS-CoV-2 infection who tested positive increased in an approximately linear manner with increasing age of the index case. Overall, 17% of household contacts of an index case tested positive within 14 days.<\/p>\n Lyngse et al. (Sept 9, 2020). COVID-19 Transmission Within Danish Households A Nationwide Study from Lockdown to Reopening. Pre-print downloaded Sep 11 from https:\/\/doi.org\/10.1101\/2020.09.09.20191239\u00a0<\/a><\/em><\/p>\n<\/p>\n<\/div>\n \t\t\t\t\t\t\t\t\t<\/p>\n<\/div>\n \t\t\t\t<\/p>\n Lopez et al. (Sept 11, 2020). Transmission Dynamics of COVID-19 Outbreaks Associated with Child Care Facilities \u2014 Salt Lake City, Utah, April\u2013July 2020. MMWR. https:\/\/doi.org\/10.15585\/mmwr.mm6937e3<\/a><\/em><\/li>\n<\/ul>\n<\/div>\n \t\t\t\t\t\t\t\t\t<\/p>\n<\/div>\n<\/div>\n<\/div>\n \t\t\t\t<\/p>\n \u2022 In preliminary findings from a randomized trial at 3 participating centers in China (n=200), recombinant human granulocyte colony-stimulating factor (rhG-CSF) treatment for patients with COVID-19 with lymphopenia but no comorbidities did not accelerate clinical improvement, but the number of patients who developed critical illness (proportion difference=-13%, 95%CI -21.4 to -5.4) or died (HR=0.19, 95%CI 0.04\u22120.88) may have been reduced. An accompanying editorial by Meyer et al. called for subsequent studies to use updated therapies from those used early in the pandemic and to include patients with comorbidities.<\/p>\n Cheng et al. (Sept 10, 2020). Effect of Recombinant Human Granulocyte Colony\u2013Stimulating Factor for Patients With Coronavirus Disease 2019 (COVID-19) and Lymphopenia. JAMA Internal Medicine. https:\/\/doi.org\/10.1001\/jamainternmed.2020.5503<\/a><\/em><\/p>\n<\/p>\n<\/div>\n \t\t\t\t\t\t\t\t\t<\/p>\n<\/div>\n<\/div>\n<\/div>\n \t\t\t\t<\/p>\n \u2022 Among 26 competitive college athletes who had tested positive for SARS-CoV-2 11-53 days earlier and had not require hospitalization, 4 (15%) had cardiac MRI findings suggestive of myocarditis (heart muscle inflammation) and 8 (31%) athletes exhibited late gadolinium enhancement (LGE) without T2 elevation, suggestive of prior myocardial injury. Cardiac ventricular function was within normal ranges for all athletes, as measured by cardiac MRI and transthoracic echocardiogram. The authors suggest that cardiac MRI may be a useful tool to risk-stratify athletes for return to competitive sports participation following recovery from COVID-19.<\/p>\n Rajpal et al. (Sept 11, 2020). Cardiovascular Magnetic Resonance Findings in Competitive Athletes Recovering From COVID-19 Infection. JAMA Cardiology. https:\/\/doi.org\/10.1001\/jamacardio.2020.4916<\/a><\/em><\/p>\n<\/p>\n<\/div>\n \t\t\t\t\t\t\t\t\t<\/p>\n<\/div>\n \t\t\t\t<\/p>\n Mouhat et al. (Sept 9, 2020). Elevated D-Dimers and Lack of Anticoagulation Predict PE in Severe COVID-19 Patients. The European Respiratory Journal. https:\/\/doi.org\/10.1183\/13993003.01811-2020<\/a><\/em><\/li>\n<\/ul>\n<\/div>\n \t\t\t\t\t\t\t\t\t<\/p>\n<\/div>\n<\/div>\n<\/div>\n \t\t\t\t<\/p>\n \u2022 Among participants in the COVID-19 Eating and Activity over Time (C-EAT) study (n=584), young adults who have experienced weight stigma were found to have increased vulnerability to distress and maladaptive eating during the COVID-19 pandemic. Pre-pandemic experiences of weight stigma predicted higher levels of depressive symptoms, stress, eating as a coping strategy, and an increased likelihood of binge eating (OR=2.9) among young adults during the pandemic. Prior weight stigma was unrelated to physical activity during the pandemic.<\/p>\n Puhl et al. (Sept 10, 2020). Weight Stigma as a Predictor of Distress and Maladaptive Eating Behaviors During COVID-19: Longitudinal Findings From the EAT Study. Annals of Behavioral Medicine. https:\/\/doi.org\/10.1093\/abm\/kaaa077<\/a><\/em><\/p>\n<\/p>\n<\/div>\n \t\t\t\t\t\t\t\t\t<\/p>\n<\/div>\n \t\t\t\t<\/p>\n Jiang et al. (Sept 10, 2020). Worries, Strategies and Confidence of Older Chinese Adults During the 2019 Novel Coronavirus Outbreak. International Journal of Geriatric Psychiatry. https:\/\/pubmed.ncbi.nlm.nih.gov\/32909299<\/a><\/em><\/li>\n<\/ul>\n<\/div>\n \t\t\t\t\t\t\t\t\t<\/p>\n<\/div>\n<\/div>\n<\/div>\n \t\t\t\t<\/p>\n \u2022 Higher proportions of Google searches for COVID-19 preventive measures were associated at the state level with longer Stay-at-Home orders and fewer COVID-19 cases after the Stay-at-Home orders expired (r=-0.33) and higher case-fatality rates (r=0.60). A moderate to strong negative correlation was found between states\u2019 percentage of voters supporting the Republican nominee in 2016 and the proportion of queries for preventative measures (r = -0.77). The proportion of queries for preventive measures were collected from Google Trends for the topics \u201chand sanitizer,\u201d \u201csocial distancing,\u201d \u201cCOVID testing,\u201d and \u201ccontact tracing,\u201d for each state.<\/p>\n Hartwell et al. (Sept 10, 2020). Association of Public Interest in Preventative Measures and Increased COVID-19 Cases after Expiration of Stay-at-Home Orders: A Cross-Sectional Study. Disaster Medicine and Public Health Preparedness. https:\/\/doi.org\/10.1017\/dmp.2020.333<\/a><\/em><\/p>\n<\/p>\n<\/div>\n \t\t\t\t\t\t\t\t\t<\/p>\n<\/div>\n \t\t\t\t<\/p>\n Bunyavanich et al. (Sept 10, 2020). Racial\/Ethnic Variation in Nasal Gene Expression of Transmembrane Serine Protease 2 (TMPRSS2). JAMA. https:\/\/doi.org\/10.1001\/jama.2020.17386<\/a><\/em><\/li>\n<\/ul>\n<\/div>\n \t\t\t\t\t\t\t\t\t<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n Report prepared by the UW MetaCenter for Pandemic Preparedness and Global Health Security and the START Center in collaboration with and on behalf of WA DOH COVID-19 Incident Management Team.<\/p>\n","protected":false},"excerpt":{"rendered":" Twelve children who acquired SARS-CoV-2 in child care facilities in Utah transmitted the infection to at least 12 out of 46 (26%) non-facility contacts. More<\/p>\nKey Takeaways<\/h2>\n
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Article Summaries<\/h3>\n
Transmission<\/h2>\n
COVID-19 Transmission Within Danish Households A Nationwide Study from Lockdown to Reopening<\/h5>\n
Transmission Dynamics of COVID-19 Outbreaks Associated with Child Care Facilities \u2014 Salt Lake City, Utah, April\u2013July 2020<\/h5>\n
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Testing and Treatment<\/h2>\n
Effect of Recombinant Human Granulocyte Colony\u2013Stimulating Factor for Patients With Coronavirus Disease 2019 (COVID-19) and Lymphopenia<\/h5>\n
Clinical Characteristics and Health Care Setting<\/h2>\n
Cardiovascular Magnetic Resonance Findings in Competitive Athletes Recovering From COVID-19 Infection<\/h5>\n
Elevated D-Dimers and Lack of Anticoagulation Predict PE in Severe COVID-19 Patients<\/h5>\n
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Mental Health and Personal Impact<\/h2>\n
Weight Stigma as a Predictor of Distress and Maladaptive Eating Behaviors During COVID-19: Longitudinal Findings From the EAT Study<\/h5>\n
Worries, Strategies and Confidence of Older Chinese Adults During the 2019 Novel Coronavirus Outbreak<\/h5>\n
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Public Health Policy and Practice<\/h2>\n
Association of Public Interest in Preventative Measures and Increased COVID-19 Cases after Expiration of Stay-at-Home Orders: A Cross-Sectional Study<\/h5>\n
Racial\/Ethnic Variation in Nasal Gene Expression of Transmembrane Serine Protease 2 (TMPRSS2)<\/h5>\n
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Other Resources and Commentaries<\/h2>\n
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\n(Sept 9)<\/li>\n
\n(Sept 10)<\/li>\n