{"id":8576,"date":"2020-07-30T11:10:49","date_gmt":"2020-07-30T18:10:49","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=8576"},"modified":"2021-04-05T11:11:31","modified_gmt":"2021-04-05T18:11:31","slug":"age-related-differences-in-nasopharyngeal-severe-acute-respiratory-syndrome-coronavirus-2-sars-cov-2-levels-in-patients-with-mild-to-moderate-coronavirus-disease-2019-covid-19","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/07\/30\/age-related-differences-in-nasopharyngeal-severe-acute-respiratory-syndrome-coronavirus-2-sars-cov-2-levels-in-patients-with-mild-to-moderate-coronavirus-disease-2019-covid-19\/","title":{"rendered":"Age-Related Differences in Nasopharyngeal Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Levels in Patients\u00a0With\u00a0Mild\u00a0To\u00a0Moderate Coronavirus Disease 2019 (COVID-19)"},"content":{"rendered":"<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"34\" data-aria-posinset=\"2019\" data-aria-level=\"1\"><span data-contrast=\"auto\">Heald-Sargent et al.\u00a0<\/span><span data-contrast=\"auto\">followed a cohort of children<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">and adults\u00a0<\/span><span data-contrast=\"auto\">(n=145)<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">with mild to moderate COVID-19\u00a0<\/span><span data-contrast=\"auto\">who were tested for SARS-CoV-2 within one week of symptom onset and\u00a0<\/span><span data-contrast=\"auto\">found that\u00a0<\/span><span data-contrast=\"auto\">the youngest children (&lt;5 years)<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">ha<\/span><span data-contrast=\"auto\">d<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">high amounts of<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">SARS-CoV-2<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">viral<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">RNA<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">in their<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">nasopharynx<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">(median\u00a0<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"none\">cycle\u00a0threshold 6.5 [4.8-12.0])<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">compared<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">with<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">older<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">children\u00a0<\/span><span data-contrast=\"none\">(11.1 [6.3-15.7])\u202f<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">and\u00a0adults<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"none\">adults\u00a0(11.0 [6.9-17.5])<\/span><span data-contrast=\"auto\">.<\/span><span data-contrast=\"auto\">\u00a0These differences correspond to a\u00a0<\/span><span data-contrast=\"auto\">10-fold to 100-fold\u00a0<\/span><span data-contrast=\"auto\">greater amount of SARS-CoV-2\u00a0<\/span><span data-contrast=\"auto\">in the respiratory tract of the youngest children.<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Heald-Sargent et al. (<\/span><\/i><i><span data-contrast=\"none\">July 30,\u00a0<\/span><\/i><i><span data-contrast=\"none\">2020). Age-Related Differences in Nasopharyngeal Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Levels in Patients\u00a0With\u00a0Mild\u00a0To<\/span><\/i><i><span data-contrast=\"none\">\u00a0Moderate Coronavirus Disease 2019 (COVID-19)<\/span><\/i><i><span data-contrast=\"none\">. JAMA Pediatrics.\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.1001\/jamapediatrics.2020.3651\"><span data-contrast=\"none\">https:\/\/doi.org\/10.1001\/jamapediatrics.2020.3651<\/span><\/a><i><span data-contrast=\"none\">\u00a0<\/span><\/i><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;335559685&quot;:720}\">\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Heald-Sargent et al.\u00a0followed a cohort of children\u00a0and adults\u00a0(n=145)\u00a0with mild to moderate COVID-19\u00a0who were tested for SARS-CoV-2 within one week of symptom onset and\u00a0found that\u00a0the youngest children (&lt;5 years)\u00a0had\u00a0high amounts of\u00a0SARS-CoV-2\u00a0viral\u00a0RNA\u00a0in their\u00a0nasopharynx\u00a0(median\u00a0\u00a0cycle\u00a0threshold 6.5 [4.8-12.0])\u00a0compared\u00a0with\u00a0older\u00a0children\u00a0(11.1 [6.3-15.7])\u202f\u00a0and\u00a0adults\u00a0adults\u00a0(11.0 [6.9-17.5]).\u00a0These differences correspond to a\u00a010-fold to 100-fold\u00a0greater amount of SARS-CoV-2\u00a0in the respiratory tract of the youngest children.\u00a0\u00a0 Heald-Sargent et al. (July&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/07\/30\/age-related-differences-in-nasopharyngeal-severe-acute-respiratory-syndrome-coronavirus-2-sars-cov-2-levels-in-patients-with-mild-to-moderate-coronavirus-disease-2019-covid-19\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[],"topic":[21],"class_list":["post-8576","post","type-post","status-publish","format-standard","hentry","category-article-summary","topic-transmission"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/8576","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=8576"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/8576\/revisions"}],"predecessor-version":[{"id":8577,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/8576\/revisions\/8577"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=8576"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=8576"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=8576"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=8576"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}