{"id":8580,"date":"2020-07-30T11:12:31","date_gmt":"2020-07-30T18:12:31","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=8580"},"modified":"2021-04-05T11:13:15","modified_gmt":"2021-04-05T18:13:15","slug":"efficacy-of-corticosteroids-in-patients-with-sars-mers-and-covid-19-a-systematic-review-and-meta-analysis","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/07\/30\/efficacy-of-corticosteroids-in-patients-with-sars-mers-and-covid-19-a-systematic-review-and-meta-analysis\/","title":{"rendered":"Efficacy of Corticosteroids in Patients with SARS, MERS and COVID-19:\u00a0A Systematic\u00a0Review and Meta-Analysis"},"content":{"rendered":"<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"34\" data-aria-posinset=\"2019\" data-aria-level=\"1\"><span data-contrast=\"auto\">A<\/span><span data-contrast=\"auto\">\u00a0systematic review and meta-analysis<\/span><span data-contrast=\"auto\">\u00a0of eight\u00a0<\/span><span data-contrast=\"auto\">studies<\/span><span data-contrast=\"auto\">\u00a0(<\/span><span data-contrast=\"auto\">8 studies with\u00a0<\/span><span data-contrast=\"auto\">4,051 patients<\/span><span data-contrast=\"auto\">)<\/span><span data-contrast=\"auto\">\u00a0evaluated the\u00a0<\/span><span data-contrast=\"auto\">benefits of steroids in patients with coronavirus infections<\/span><span data-contrast=\"auto\">.<\/span><span data-contrast=\"auto\">\u00a0Among\u00a0<\/span><span data-contrast=\"auto\">the\u00a0<\/span><span data-contrast=\"auto\">studies, 3<\/span><span data-contrast=\"auto\">,<\/span><span data-contrast=\"auto\">416 patients were diagnosed with SARS, 360 patients with MERS, and 275 with COVID-19; 60% patients were administered steroids.<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">The meta-analyses including all studies showed no differences overall in terms of mortality (OR<\/span><span data-contrast=\"auto\">=<\/span><span data-contrast=\"auto\">1.15<\/span><span data-contrast=\"auto\">;<\/span><span data-contrast=\"auto\">\u00a095% CI 0.63-2.10). However, in some studies the patients in the steroid group had more severe symptoms than those in the control group. In contrast, when the meta-analysis was performed restricting only to studies that used appropriate adjustment (e.g., time, disease severity),\u00a0<\/span><span data-contrast=\"auto\">use of steroids was associated with a lower risk of mortality<\/span><span data-contrast=\"auto\">\u00a0(HR<\/span><span data-contrast=\"auto\">=<\/span><span data-contrast=\"auto\">0.3<\/span><span data-contrast=\"auto\">8<\/span><span data-contrast=\"auto\">;<\/span><span data-contrast=\"auto\">\u00a095% CI 0.22-0.6<\/span><span data-contrast=\"auto\">5<\/span><span data-contrast=\"auto\">).\u00a0<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Lee et al. (July 2020). Efficacy of Corticosteroids in Patients with SARS, MERS and COVID-19:\u00a0A Systematic\u00a0Review and Meta-Analysis. Journal of Clinical Medicine.\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.3390\/jcm9082392\"><span data-contrast=\"none\">https:\/\/doi.org\/10.3390\/jcm9082392<\/span><\/a><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;335559685&quot;:720}\">\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A\u00a0systematic review and meta-analysis\u00a0of eight\u00a0studies\u00a0(8 studies with\u00a04,051 patients)\u00a0evaluated the\u00a0benefits of steroids in patients with coronavirus infections.\u00a0Among\u00a0the\u00a0studies, 3,416 patients were diagnosed with SARS, 360 patients with MERS, and 275 with COVID-19; 60% patients were administered steroids.\u00a0The meta-analyses including all studies showed no differences overall in terms of mortality (OR=1.15;\u00a095% CI 0.63-2.10). However, in some studies the&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/07\/30\/efficacy-of-corticosteroids-in-patients-with-sars-mers-and-covid-19-a-systematic-review-and-meta-analysis\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[],"topic":[19],"class_list":["post-8580","post","type-post","status-publish","format-standard","hentry","category-article-summary","topic-testing-and-treatment"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/8580","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=8580"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/8580\/revisions"}],"predecessor-version":[{"id":8581,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/8580\/revisions\/8581"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=8580"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=8580"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=8580"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=8580"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}