{"id":8635,"date":"2021-04-05T10:05:16","date_gmt":"2021-04-05T17:05:16","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=8635"},"modified":"2021-04-06T10:06:04","modified_gmt":"2021-04-06T17:06:04","slug":"infection-and-vaccine-induced-antibody-binding-and-neutralization-of-the-b-1-351-sars-cov-2-variant","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/04\/05\/infection-and-vaccine-induced-antibody-binding-and-neutralization-of-the-b-1-351-sars-cov-2-variant\/","title":{"rendered":"Infection- and Vaccine-Induced Antibody Binding and Neutralization of the B.1.351 SARS-CoV-2 Variant"},"content":{"rendered":"<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Acutely infected COVID-19 patients and those who received the Moderna vaccine had significantly reduced IgG binding to the B.1.351 variant receptor binding domain (RBD) compared to the B.1-lineage RBD-specific IgG response. However, sera containing polyclonal antibodies to the spike protein could still effectively neutralize B.1.351. Individuals with prior infection or vaccinated individuals had a nearly 3-fold reduction in binding antibody titers to the B.1.351 variant against the RBD of the spike protein and a 3.5-fold reduction in neutralizing antibody titers compared to the B.1 variant.<\/span><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Edara et al. (Mar 2021). Infection- and Vaccine-Induced Antibody Binding and Neutralization of the B.1.351 SARS-CoV-2 Variant. Cell Host &amp; Microbe. <\/span><\/i><a href=\"https:\/\/doi.org\/10.1016\/j.chom.2021.03.009\"><span style=\"font-weight: 400\">https:\/\/doi.org\/10.1016\/j.chom.2021.03.009<\/span><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Acutely infected COVID-19 patients and those who received the Moderna vaccine had significantly reduced IgG binding to the B.1.351 variant receptor binding domain (RBD) compared to the B.1-lineage RBD-specific IgG response. However, sera containing polyclonal antibodies to the spike protein could still effectively neutralize B.1.351. Individuals with prior infection or vaccinated individuals had a nearly&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/04\/05\/infection-and-vaccine-induced-antibody-binding-and-neutralization-of-the-b-1-351-sars-cov-2-variant\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[142,159],"topic":[21],"class_list":["post-8635","post","type-post","status-publish","format-standard","hentry","category-article-summary","tag-vaccine","tag-variants","topic-transmission"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/8635","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=8635"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/8635\/revisions"}],"predecessor-version":[{"id":8636,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/8635\/revisions\/8636"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=8635"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=8635"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=8635"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=8635"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}