{"id":8679,"date":"2020-08-03T10:42:48","date_gmt":"2020-08-03T17:42:48","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=8679"},"modified":"2021-04-06T10:43:38","modified_gmt":"2021-04-06T17:43:38","slug":"household-transmission-of-sars-cov-2-a-systematic-review-and-meta-analysis-of-secondary-attack-rate","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/08\/03\/household-transmission-of-sars-cov-2-a-systematic-review-and-meta-analysis-of-secondary-attack-rate\/","title":{"rendered":"Household Transmission of SARS-CoV-2 a Systematic Review and Meta-Analysis of Secondary Attack Rate"},"content":{"rendered":"<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"34\" data-aria-posinset=\"1\" data-aria-level=\"1\"><i><span data-contrast=\"none\">[Preprint, not peer-reviewed]\u00a0<\/span><\/i><span data-contrast=\"none\">Madewell et al. performed a meta-analysis<\/span><span data-contrast=\"none\">\u00a0of\u00a0<\/span><span data-contrast=\"none\">40 studies of SARS-CoV-2 household secondary attack rate (SAR). Overall<\/span><span data-contrast=\"auto\">,<\/span><span data-contrast=\"none\">\u00a0the estimated mean SAR for household contacts was 19% (95%CI 15%\u201323%) and family contacts\u00a0<\/span><span data-contrast=\"none\">wa<\/span><span data-contrast=\"none\">s\u00a0<\/span><span data-contrast=\"none\">18% (13%\u201335%), both with significant heterogeneity. SARs were significantly higher from symptomatic index cases than asymptomatic index cases (20% vs. 1%), to adult contacts than\u00a0<\/span><span data-contrast=\"none\">to\u00a0<\/span><span data-contrast=\"none\">child contacts (31% vs. 16%), to spouses than other family contacts (43% vs. 18%), and in households with one contact than\u00a0<\/span><span data-contrast=\"none\">in\u00a0<\/span><span data-contrast=\"none\">households with three or more contacts (45% vs. 25%)<\/span><span data-contrast=\"none\">, though the authors note that the analysis does not adjust for\u00a0<\/span><span data-contrast=\"none\">hosuehold<\/span><span data-contrast=\"none\">\u00a0crowding.\u00a0<\/span><span data-contrast=\"none\">[<\/span><i><span data-contrast=\"none\">Editorial note: This analysis did not have strict\u00a0<\/span><\/i><i><span data-contrast=\"none\">temporal<\/span><\/i><i><span data-contrast=\"none\">\u00a0criteria for the identification of\u00a0<\/span><\/i><i><span data-contrast=\"none\">a<\/span><\/i><i><span data-contrast=\"none\">\u00a0case relative to other cases in the household, which may inflate the estimated SARs<\/span><\/i><i><span data-contrast=\"none\">.<\/span><\/i><span data-contrast=\"none\">]<\/span><span data-contrast=\"none\">\u00a0<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Madewell et al. (Aug 1, 2020). Household Transmission of SARS-CoV-2 a Systematic Review and Meta-Analysis of Secondary Attack Rate.\u00a0<\/span><\/i><i><span data-contrast=\"none\">Pre-print downloaded Aug 3 from\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.1101\/2020.07.29.20164590\"><i><span data-contrast=\"none\">https:\/\/doi.org\/10.1101\/2020.07.29.20164590<\/span><\/i><\/a><i><span data-contrast=\"none\">\u00a0<\/span><\/i><i><span data-contrast=\"none\">\u00a0<\/span><\/i><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:240}\">\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>[Preprint, not peer-reviewed]\u00a0Madewell et al. performed a meta-analysis\u00a0of\u00a040 studies of SARS-CoV-2 household secondary attack rate (SAR). Overall,\u00a0the estimated mean SAR for household contacts was 19% (95%CI 15%\u201323%) and family contacts\u00a0was\u00a018% (13%\u201335%), both with significant heterogeneity. SARs were significantly higher from symptomatic index cases than asymptomatic index cases (20% vs. 1%), to adult contacts than\u00a0to\u00a0child contacts&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/08\/03\/household-transmission-of-sars-cov-2-a-systematic-review-and-meta-analysis-of-secondary-attack-rate\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[],"topic":[21],"class_list":["post-8679","post","type-post","status-publish","format-standard","hentry","category-article-summary","topic-transmission"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/8679","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=8679"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/8679\/revisions"}],"predecessor-version":[{"id":8680,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/8679\/revisions\/8680"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=8679"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=8679"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=8679"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=8679"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}