{"id":8689,"date":"2020-08-03T10:47:53","date_gmt":"2020-08-03T17:47:53","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=8689"},"modified":"2021-04-06T10:48:32","modified_gmt":"2021-04-06T17:48:32","slug":"drug-treatments-for-covid-19-living-systematic-review-and-network-meta-analysis","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/08\/03\/drug-treatments-for-covid-19-living-systematic-review-and-network-meta-analysis\/","title":{"rendered":"Drug Treatments for Covid-19: Living Systematic Review and Network Meta-Analysis"},"content":{"rendered":"<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"34\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"auto\">A\u00a0<\/span><span data-contrast=\"auto\">network\u00a0<\/span><span data-contrast=\"auto\">meta-analysis of 23 RCTs\u00a0<\/span><span data-contrast=\"auto\">evaluating treatments for COVID-19 found that\u00a0<\/span><span data-contrast=\"auto\">glucocorticoids were the only intervention with evidence for a reduction in\u00a0<\/span><span data-contrast=\"auto\">mortality\u00a0<\/span><span data-contrast=\"auto\">compared with standard care (risk difference 37 fewer per 1000 patients, 95%CI 11-63) and\u00a0<\/span><span data-contrast=\"auto\">need for<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">mechanical ventilation (31 fewer per 1000 patients, 95%CI 9-47). Three drugs might reduce symptom duration compared with standard care: hydroxychloroquine (mean difference -4.5 days),\u00a0<\/span><span data-contrast=\"auto\">remdesivir<\/span><span data-contrast=\"auto\">\u00a0(-2.6 days), and lopinavir-ritonavir (-1.2 days). Overall\u00a0<\/span><span data-contrast=\"auto\">evidence<\/span><span data-contrast=\"auto\">\u00a0of treatments for COVID-19 showed a low certainty of evidence due to lack of blinding and imprecision<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">of<\/span><span data-contrast=\"auto\">\u00a0estimates<\/span><span data-contrast=\"auto\">.\u00a0<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:240}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Siemieniuk<\/span><\/i><i><span data-contrast=\"none\">\u00a0et al. (July 30, 2020). Drug Treatments for Covid-19: Living Systematic Review and Network Meta-Analysis. BMJ.<\/span><\/i><i><span data-contrast=\"none\">\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.1136\/bmj.m2980\"><span data-contrast=\"none\">https:\/\/doi.org\/10.1136\/bmj.m2980<\/span><\/a><i><span data-contrast=\"none\">\u00a0\u00a0\u00a0<\/span><\/i><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:240}\">\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A\u00a0network\u00a0meta-analysis of 23 RCTs\u00a0evaluating treatments for COVID-19 found that\u00a0glucocorticoids were the only intervention with evidence for a reduction in\u00a0mortality\u00a0compared with standard care (risk difference 37 fewer per 1000 patients, 95%CI 11-63) and\u00a0need for\u00a0mechanical ventilation (31 fewer per 1000 patients, 95%CI 9-47). Three drugs might reduce symptom duration compared with standard care: hydroxychloroquine (mean difference -4.5&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/08\/03\/drug-treatments-for-covid-19-living-systematic-review-and-network-meta-analysis\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[],"topic":[19],"class_list":["post-8689","post","type-post","status-publish","format-standard","hentry","category-article-summary","topic-testing-and-treatment"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/8689","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=8689"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/8689\/revisions"}],"predecessor-version":[{"id":8690,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/8689\/revisions\/8690"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=8689"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=8689"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=8689"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=8689"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}