{"id":8691,"date":"2020-08-03T10:48:38","date_gmt":"2020-08-03T17:48:38","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=8691"},"modified":"2021-04-06T10:49:25","modified_gmt":"2021-04-06T17:49:25","slug":"vertical-transmission-of-covid-19-a-systematic-review-and-meta-analysis","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/08\/03\/vertical-transmission-of-covid-19-a-systematic-review-and-meta-analysis\/","title":{"rendered":"Vertical Transmission of COVID-19: A Systematic Review and Meta-Analysis"},"content":{"rendered":"<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"34\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"auto\">Kotlyar<\/span><span data-contrast=\"auto\">\u00a0et al.<\/span><span data-contrast=\"auto\">\u00a0pooled results of from 38 studies with 936 neonates<\/span><span data-contrast=\"auto\">\u00a0to investigate\u00a0<\/span><span data-contrast=\"auto\">SARS-CoV-2 vertical transmission<\/span><span data-contrast=\"auto\">. The<\/span><span data-contrast=\"auto\">y found that the<\/span><span data-contrast=\"auto\">\u00a0proportion of vertical transmission based on RNA PCR results\u00a0<\/span><span data-contrast=\"auto\">from<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">infant\u00a0<\/span><span data-contrast=\"auto\">nasopharyngeal swab<\/span><span data-contrast=\"auto\">s<\/span><span data-contrast=\"auto\">\u00a0was 3.2% (95%CI 2.2-4.3%). The neonatal serology\u00a0<\/span><span data-contrast=\"auto\">(IgM)\u00a0<\/span><span data-contrast=\"auto\">was positive in 3.7% (3\/82). The<\/span><span data-contrast=\"auto\">\u00a0authors note<\/span><span data-contrast=\"auto\">\u00a0that<\/span><span data-contrast=\"auto\">\u00a0the\u00a0<\/span><span data-contrast=\"auto\">majority of\u00a0<\/span><span data-contrast=\"auto\">mothers<\/span><span data-contrast=\"auto\">\u00a0in their sample were likely infected during the third trimester of pregnancy<\/span><span data-contrast=\"auto\">,<\/span><span data-contrast=\"auto\">\u00a0and that\u00a0<\/span><span data-contrast=\"auto\">the risk<\/span><span data-contrast=\"auto\">\u00a0of vertical transmission as well as potential risk for consequent fetal morbidity and mortality<\/span><span data-contrast=\"auto\">\u00a0may differ for pregnant women infected in early pregnancy<\/span><span data-contrast=\"auto\">.<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:240}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Kotlyar<\/span><\/i><i><span data-contrast=\"none\">\u00a0et al. (July 30, 2020). Vertical Transmission of COVID-19: A Systematic Review and Meta-<\/span><\/i><i><span data-contrast=\"none\">Analysis. American Journal of Obstetrics and Gynecology.<\/span><\/i><i><span data-contrast=\"none\">\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.1016\/j.ajog.2020.07.049\"><span data-contrast=\"none\">https:\/\/doi.org\/10.1016\/j.ajog.2020.07.049<\/span><\/a><i><span data-contrast=\"none\">\u00a0<\/span><\/i><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:240}\">\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Kotlyar\u00a0et al.\u00a0pooled results of from 38 studies with 936 neonates\u00a0to investigate\u00a0SARS-CoV-2 vertical transmission. They found that the\u00a0proportion of vertical transmission based on RNA PCR results\u00a0from\u00a0infant\u00a0nasopharyngeal swabs\u00a0was 3.2% (95%CI 2.2-4.3%). The neonatal serology\u00a0(IgM)\u00a0was positive in 3.7% (3\/82). The\u00a0authors note\u00a0that\u00a0the\u00a0majority of\u00a0mothers\u00a0in their sample were likely infected during the third trimester of pregnancy,\u00a0and that\u00a0the risk\u00a0of vertical transmission as&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/08\/03\/vertical-transmission-of-covid-19-a-systematic-review-and-meta-analysis\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[],"topic":[20],"class_list":["post-8691","post","type-post","status-publish","format-standard","hentry","category-article-summary","topic-clinical-characteristics-and-health-care-setting"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/8691","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=8691"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/8691\/revisions"}],"predecessor-version":[{"id":8692,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/8691\/revisions\/8692"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=8691"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=8691"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=8691"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=8691"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}