{"id":8715,"date":"2020-08-04T11:04:32","date_gmt":"2020-08-04T18:04:32","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=8715"},"modified":"2021-04-06T11:05:13","modified_gmt":"2021-04-06T18:05:13","slug":"evaluation-of-serological-sars-cov-2-lateral-flow-assays-for-rapid-point-of-care-testing","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/08\/04\/evaluation-of-serological-sars-cov-2-lateral-flow-assays-for-rapid-point-of-care-testing\/","title":{"rendered":"Evaluation of Serological SARS-CoV-2 Lateral Flow Assays for Rapid Point of Care Testing"},"content":{"rendered":"<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"45\" data-aria-posinset=\"1\" data-aria-level=\"1\"><i><span data-contrast=\"none\">[pre-print, not peer-reviewed]<\/span><\/i><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">Conklin et al. evaluated 15 different rapid point-of-care tests for SARS-CoV-2 antibodies<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">from<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">40<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">SARS-CoV-2 infected,<\/span><span data-contrast=\"auto\">\u00a0convalescent\u00a0<\/span><span data-contrast=\"auto\">individuals<\/span><span data-contrast=\"auto\">\u00a0(average 45 days\u00a0<\/span><span data-contrast=\"auto\">post-s<\/span><span data-contrast=\"auto\">ymptom onset)\u00a0<\/span><span data-contrast=\"auto\">and 60 pre-pandemic samples from negative control individuals (known to be infected with other respiratory viruses; rhinoviruses and coronaviruses).<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">Overall, s<\/span><span data-contrast=\"auto\">ensitivity ranged from 55-97%, and\u00a0<\/span><span data-contrast=\"auto\">s<\/span><span data-contrast=\"auto\">pecificity ranged from 78-100%.\u00a0<\/span><span data-contrast=\"auto\">Sensitivity and specific<\/span><span data-contrast=\"auto\">ity values<\/span><span data-contrast=\"auto\">\u00a0were higher for IgG\u00a0<\/span><span data-contrast=\"auto\">alone\u00a0<\/span><span data-contrast=\"auto\">than for IgM<\/span><span data-contrast=\"auto\">\u00a0alone<\/span><span data-contrast=\"auto\">.<\/span><span data-contrast=\"auto\">\u00a0Cross<\/span><span data-contrast=\"auto\">&#8211;<\/span><span data-contrast=\"auto\">reactivity was more pronounced with sera from patients infected with strains of coronaviruses other than SARS-CoV-2<\/span><span data-contrast=\"auto\">. Median time post<\/span><span data-contrast=\"auto\">&#8211;<\/span><span data-contrast=\"auto\">symptom onset to a positive result was 7 days for IgM (IQR 5.4, 9.8) and 8.2 days for IgG (IQR 6.3, 11.3).\u00a0<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:240}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Conklin et al. (August 4, 2020). Evaluation of Serological SARS-CoV-2 Lateral Flow Assays for Rapid Point of Care Testing. Pre-print downloaded on August 4 from\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.1101\/2020.07.31.20166041\"><span data-contrast=\"none\">https:\/\/doi.org\/10.1101\/2020.07.31.20166041<\/span><\/a><i><span data-contrast=\"none\">\u00a0<\/span><\/i><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:240}\">\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>[pre-print, not peer-reviewed]\u00a0Conklin et al. evaluated 15 different rapid point-of-care tests for SARS-CoV-2 antibodies\u00a0from\u00a040\u00a0SARS-CoV-2 infected,\u00a0convalescent\u00a0individuals\u00a0(average 45 days\u00a0post-symptom onset)\u00a0and 60 pre-pandemic samples from negative control individuals (known to be infected with other respiratory viruses; rhinoviruses and coronaviruses).\u00a0Overall, sensitivity ranged from 55-97%, and\u00a0specificity ranged from 78-100%.\u00a0Sensitivity and specificity values\u00a0were higher for IgG\u00a0alone\u00a0than for IgM\u00a0alone.\u00a0Cross&#8211;reactivity was more pronounced&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/08\/04\/evaluation-of-serological-sars-cov-2-lateral-flow-assays-for-rapid-point-of-care-testing\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[],"topic":[19],"class_list":["post-8715","post","type-post","status-publish","format-standard","hentry","category-article-summary","topic-testing-and-treatment"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/8715","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=8715"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/8715\/revisions"}],"predecessor-version":[{"id":8716,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/8715\/revisions\/8716"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=8715"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=8715"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=8715"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=8715"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}