{"id":8736,"date":"2020-08-05T11:16:19","date_gmt":"2020-08-05T18:16:19","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=8736"},"modified":"2021-04-06T11:17:04","modified_gmt":"2021-04-06T18:17:04","slug":"evidence-based-considerations-exploring-relations-between-sars-cov-2-pandemic-and-air-pollution-involvement-of-pm2-5-mediated-up-regulation-of-the-viral-receptor-ace-2","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/08\/05\/evidence-based-considerations-exploring-relations-between-sars-cov-2-pandemic-and-air-pollution-involvement-of-pm2-5-mediated-up-regulation-of-the-viral-receptor-ace-2\/","title":{"rendered":"Evidence-Based Considerations Exploring Relations between SARS-CoV-2 Pandemic and Air Pollution: Involvement of PM2.5-Mediated Up-Regulation of the Viral Receptor ACE-2"},"content":{"rendered":"<ul>\n<li><span data-contrast=\"auto\">A<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">correlat<\/span><span data-contrast=\"auto\">ion<\/span><span data-contrast=\"auto\">\u00a0analysis of air quality and COVID-19 incidence and mortality in Italy suggested that\u00a0<\/span><span data-contrast=\"auto\">higher<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">concentrations of fine particulate matter<\/span><span data-contrast=\"auto\">\u00a0(PM<\/span><span data-contrast=\"auto\">2.5<\/span><span data-contrast=\"auto\">)<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">corresponded\u00a0<\/span><span data-contrast=\"auto\">temporally\u00a0<\/span><span data-contrast=\"auto\">with\u00a0<\/span><span data-contrast=\"auto\">higher\u00a0<\/span><span data-contrast=\"auto\">COVID-19 incidence, mortality, and\u00a0<\/span><span data-contrast=\"auto\">case fatality ratios\u00a0<\/span><span data-contrast=\"auto\">across 110 geographic areas in Northern Italy.\u00a0<\/span><span data-contrast=\"auto\">The infection rate\u00a0<\/span><span data-contrast=\"auto\">tripled\u00a0<\/span><span data-contrast=\"auto\">for<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">PM<\/span><span data-contrast=\"auto\">2.5<\/span><span data-contrast=\"auto\">\u00a0levels increasing from 10 to 25 \u00b5g\/m3 and the case fatality\u00a0<\/span><span data-contrast=\"auto\">double<\/span><span data-contrast=\"auto\">d<\/span><span data-contrast=\"auto\">\u00a0for\u00a0<\/span><span data-contrast=\"auto\">PM<\/span><span data-contrast=\"auto\">2.<\/span><span data-contrast=\"auto\">5<\/span><span data-contrast=\"auto\">\u00a0levels increasing from 10 to 22 \u00b5g\/m3.\u00a0<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:120,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"12\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"auto\">The<\/span><span data-contrast=\"auto\">\u00a0authors propose a potential mechanism for this observation<\/span><span data-contrast=\"auto\">\u00a0due to upregulation of\u00a0<\/span><span data-contrast=\"auto\">expression of\u00a0<\/span><span data-contrast=\"auto\">the ACE-2 gene<\/span><span data-contrast=\"auto\">\u00a0by\u00a0<\/span><span data-contrast=\"auto\">pollutants\u00a0<\/span><span data-contrast=\"auto\">mediated\u00a0<\/span><span data-contrast=\"auto\">through the aryl<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">hydrocarbon receptor<\/span><span data-contrast=\"auto\">.\u00a0<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:120,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Borro<\/span><\/i><i><span data-contrast=\"none\">\u00a0et al. (Aug 2, 2020). Evidence-Based Considerations Exploring Relations between SARS-CoV-2 Pandemic and Air Pollution: Involvement of PM2.5-Mediated Up-Regulation of the Viral Receptor ACE-2. International Journal of Environmental Research and Public Health.\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.3390\/ijerph17155573\"><span data-contrast=\"none\">https:\/\/doi.org\/10.3390\/ijerph17155573<\/span><\/a><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:120,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A\u00a0correlation\u00a0analysis of air quality and COVID-19 incidence and mortality in Italy suggested that\u00a0higher\u00a0concentrations of fine particulate matter\u00a0(PM2.5)\u00a0corresponded\u00a0temporally\u00a0with\u00a0higher\u00a0COVID-19 incidence, mortality, and\u00a0case fatality ratios\u00a0across 110 geographic areas in Northern Italy.\u00a0The infection rate\u00a0tripled\u00a0for\u00a0PM2.5\u00a0levels increasing from 10 to 25 \u00b5g\/m3 and the case fatality\u00a0doubled\u00a0for\u00a0PM2.5\u00a0levels increasing from 10 to 22 \u00b5g\/m3.\u00a0\u00a0 The\u00a0authors propose a potential mechanism for this observation\u00a0due to&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/08\/05\/evidence-based-considerations-exploring-relations-between-sars-cov-2-pandemic-and-air-pollution-involvement-of-pm2-5-mediated-up-regulation-of-the-viral-receptor-ace-2\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[],"topic":[21],"class_list":["post-8736","post","type-post","status-publish","format-standard","hentry","category-article-summary","topic-transmission"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/8736","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=8736"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/8736\/revisions"}],"predecessor-version":[{"id":8737,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/8736\/revisions\/8737"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=8736"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=8736"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=8736"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=8736"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}