{"id":8767,"date":"2020-08-06T11:31:49","date_gmt":"2020-08-06T18:31:49","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=8767"},"modified":"2021-04-06T11:32:29","modified_gmt":"2021-04-06T18:32:29","slug":"rapid-gmp-compliant-expansion-of-sars-cov-2-specific-t-cells-from-convalescent-donors-for-use-as-an-allogeneic-cell-therapy-for-covid-19","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/08\/06\/rapid-gmp-compliant-expansion-of-sars-cov-2-specific-t-cells-from-convalescent-donors-for-use-as-an-allogeneic-cell-therapy-for-covid-19\/","title":{"rendered":"Rapid GMP-Compliant Expansion of SARS-CoV-2-Specific T Cells from Convalescent Donors for Use as an Allogeneic Cell Therapy for COVID-19"},"content":{"rendered":"<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"34\" data-aria-posinset=\"1\" data-aria-level=\"1\"><i><span data-contrast=\"none\">[<\/span><\/i><i><span data-contrast=\"none\">Preprint<\/span><\/i><i><span data-contrast=\"none\">, not peer-reviewed]<\/span><\/i><i><span data-contrast=\"none\">\u00a0<\/span><\/i><span data-contrast=\"auto\">Cooper et al.<\/span><span data-contrast=\"auto\">\u00a0isolated CD4 and CD8 memory T cells specific\u00a0<\/span><span data-contrast=\"auto\">to\u00a0<\/span><span data-contrast=\"auto\">SARS-CoV-2 spike, nucleocapsid<\/span><span data-contrast=\"auto\">,<\/span><span data-contrast=\"auto\">\u00a0and membrane antigens from convalescent\u00a0<\/span><span data-contrast=\"auto\">plasma\u00a0<\/span><span data-contrast=\"auto\">donors who\u00a0<\/span><span data-contrast=\"auto\">had\u00a0<\/span><span data-contrast=\"auto\">recovered from\u00a0<\/span><span data-contrast=\"auto\">mild\u00a0<\/span><span data-contrast=\"auto\">SARS-CoV-2\u00a0<\/span><span data-contrast=\"auto\">infection<\/span><span data-contrast=\"auto\">.<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">They<\/span><span data-contrast=\"auto\">\u00a0report\u00a0<\/span><span data-contrast=\"auto\">that these T cells can be rapidly expanded to therapeutic doses\u00a0<\/span><span data-contrast=\"auto\">while\u00a0<\/span><span data-contrast=\"auto\">maintaining the desired central memory phenotype required for protective immune responses against severe COVID-19 infections.<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Cooper et al. (Aug 5, 2020). Rapid GMP-Compliant Expansion of SARS-CoV-2-Specific T Cells from Convalescent Donors for Use as an Allogeneic Cell Therapy for COVID-19.\u00a0<\/span><\/i><i><span data-contrast=\"none\">Pre-print\u00a0downloaded Aug 6 from\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.1101\/2020.08.05.237867\"><span data-contrast=\"none\">https:\/\/doi.org\/10.1101\/2020.08.05.237867<\/span><\/a><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>[Preprint, not peer-reviewed]\u00a0Cooper et al.\u00a0isolated CD4 and CD8 memory T cells specific\u00a0to\u00a0SARS-CoV-2 spike, nucleocapsid,\u00a0and membrane antigens from convalescent\u00a0plasma\u00a0donors who\u00a0had\u00a0recovered from\u00a0mild\u00a0SARS-CoV-2\u00a0infection.\u00a0They\u00a0report\u00a0that these T cells can be rapidly expanded to therapeutic doses\u00a0while\u00a0maintaining the desired central memory phenotype required for protective immune responses against severe COVID-19 infections.\u00a0 Cooper et al. (Aug 5, 2020). Rapid GMP-Compliant Expansion of SARS-CoV-2-Specific&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/08\/06\/rapid-gmp-compliant-expansion-of-sars-cov-2-specific-t-cells-from-convalescent-donors-for-use-as-an-allogeneic-cell-therapy-for-covid-19\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[],"topic":[19],"class_list":["post-8767","post","type-post","status-publish","format-standard","hentry","category-article-summary","topic-testing-and-treatment"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/8767","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=8767"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/8767\/revisions"}],"predecessor-version":[{"id":8768,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/8767\/revisions\/8768"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=8767"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=8767"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=8767"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=8767"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}