{"id":8794,"date":"2021-04-06T10:13:48","date_gmt":"2021-04-06T17:13:48","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=8794"},"modified":"2021-04-07T10:14:35","modified_gmt":"2021-04-07T17:14:35","slug":"reactogenicity-following-receipt-of-mrna-based-covid-19-vaccines","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/04\/06\/reactogenicity-following-receipt-of-mrna-based-covid-19-vaccines\/","title":{"rendered":"Reactogenicity Following Receipt of mRNA-Based COVID-19 Vaccines"},"content":{"rendered":"<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Local and systemic adverse reactions within 7 days of vaccination were more frequently self-reported by those who received the Moderna vaccine compared to those who received the Pfizer-BioNTech vaccines. Reactions were also more frequently reported after the second dose of these vaccines. These findings are based on V-Safe, a CDC surveillance system that included 3.6 million first-dose recipients and 1.9 million second-dose recipients up to February 21, 2021. Injection site reactions within 7 days were reported by 70% and 75% of first- and second-dose recipients, while systemic reactions within 7 days of vaccination were reported by 50% and 69% of first- and second-dose recipients. The most frequently reported solicited reactions after the first dose were injection site pain (68%), fatigue (31%), and headache (26%), and for the second dose were fatigue (54%), headache (47%), and myalgia (44%). Reported reactions were highest on day 1 after vaccination and declined markedly through day 7. These findings are generally consistent with frequencies observed in clinical trials.<\/span><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Chapin-Bardales et al.\u00a0(Apr 5, 2021). Reactogenicity Following Receipt of mRNA-Based COVID-19 Vaccines. JAMA. <\/span><\/i><a href=\"https:\/\/doi.org\/10.1001\/jama.2021.5374\"><span style=\"font-weight: 400\">https:\/\/doi.org\/10.1001\/jama.2021.5374<\/span><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Local and systemic adverse reactions within 7 days of vaccination were more frequently self-reported by those who received the Moderna vaccine compared to those who received the Pfizer-BioNTech vaccines. Reactions were also more frequently reported after the second dose of these vaccines. These findings are based on V-Safe, a CDC surveillance system that included 3.6&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/04\/06\/reactogenicity-following-receipt-of-mrna-based-covid-19-vaccines\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[147],"topic":[31],"class_list":["post-8794","post","type-post","status-publish","format-standard","hentry","category-article-summary","tag-vaccination","topic-vaccines-and-immunity"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/8794","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=8794"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/8794\/revisions"}],"predecessor-version":[{"id":8795,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/8794\/revisions\/8795"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=8794"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=8794"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=8794"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=8794"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}