{"id":8836,"date":"2021-04-07T11:02:32","date_gmt":"2021-04-07T18:02:32","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=8836"},"modified":"2021-04-12T11:03:21","modified_gmt":"2021-04-12T18:03:21","slug":"antibody-persistence-through-6-months-after-the-second-dose-of-mrna-1273-vaccine-for-covid-19","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/04\/07\/antibody-persistence-through-6-months-after-the-second-dose-of-mrna-1273-vaccine-for-covid-19\/","title":{"rendered":"Antibody Persistence through 6 Months after the Second Dose of MRNA-1273 Vaccine for Covid-19"},"content":{"rendered":"<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Neutralizing antibody activity elicited by the Moderna vaccine remained high 6 months after the second dose in all 33 adults in an ongoing phase 1 trial, as measured by 3 different serologic assays. Binding antibody half-life estimates after day 43 for all the participants were 52 days when calculated via an exponential decay model (assumes a steady decay rate), and 109 days via a power-law model at day 119 (assumes decay rates decrease over time). <\/span><span style=\"font-weight: 400\">Neutralizing antibody half-life estimates in the two models were 69 days and 173 days for pseudovirus neutralization, and 68 days and 202 days for live-virus neutralization.\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Doria-Rose et al.\u00a0(Apr 6, 2021). Antibody Persistence through 6 Months after the Second Dose of MRNA-1273 Vaccine for Covid-19. New England Journal of Medicine. <\/span><\/i><a href=\"https:\/\/doi.org\/10.1056\/NEJMc2103916\"><span style=\"font-weight: 400\">https:\/\/doi.org\/10.1056\/NEJMc2103916<\/span><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Neutralizing antibody activity elicited by the Moderna vaccine remained high 6 months after the second dose in all 33 adults in an ongoing phase 1 trial, as measured by 3 different serologic assays. Binding antibody half-life estimates after day 43 for all the participants were 52 days when calculated via an exponential decay model (assumes&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/04\/07\/antibody-persistence-through-6-months-after-the-second-dose-of-mrna-1273-vaccine-for-covid-19\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[32,33],"topic":[31],"class_list":["post-8836","post","type-post","status-publish","format-standard","hentry","category-article-summary","tag-immunity","tag-vaccines","topic-vaccines-and-immunity"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/8836","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=8836"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/8836\/revisions"}],"predecessor-version":[{"id":8837,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/8836\/revisions\/8837"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=8836"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=8836"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=8836"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=8836"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}