{"id":8851,"date":"2021-04-08T11:14:04","date_gmt":"2021-04-08T18:14:04","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=8851"},"modified":"2021-04-13T10:54:30","modified_gmt":"2021-04-13T17:54:30","slug":"functional-evaluation-of-proteolytic-activation-for-the-sars-cov-2-variant-b-1-1-7-role-of-the-p681h-mutation","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/04\/08\/functional-evaluation-of-proteolytic-activation-for-the-sars-cov-2-variant-b-1-1-7-role-of-the-p681h-mutation\/","title":{"rendered":"Functional Evaluation of Proteolytic Activation for the SARS-CoV-2 Variant B.1.1.7 Role of the P681H Mutation"},"content":{"rendered":"<ul>\n<li style=\"font-weight: 400\"><i><span style=\"font-weight: 400\">[Pre-print, not peer-reviewed]<\/span><\/i> <i><span style=\"font-weight: 400\">In vitro<\/span><\/i><span style=\"font-weight: 400\"> experiments show that while the P681H mutation found in the SARS-CoV-2 B.1.1.7 variant was associated with more efficient cleavage of the Spike 1 and Spike 2 (S1\/S2) subunits, this did not translate to a significant impact on cell entry or an increase in cell-to- cell spread.<\/span><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Lubinski et al.\u00a0(Apr 8, 2021). Functional Evaluation of Proteolytic Activation for the SARS-CoV-2 Variant B.1.1.7 Role of the P681H Mutation. Pre-print downloaded Apr 8 from <\/span><\/i><a href=\"https:\/\/doi.org\/10.1101\/2021.04.06.438731\"><span style=\"font-weight: 400\">https:\/\/doi.org\/10.1101\/2021.04.06.438731<\/span><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>[Pre-print, not peer-reviewed] In vitro experiments show that while the P681H mutation found in the SARS-CoV-2 B.1.1.7 variant was associated with more efficient cleavage of the Spike 1 and Spike 2 (S1\/S2) subunits, this did not translate to a significant impact on cell entry or an increase in cell-to- cell spread. Lubinski et al.\u00a0(Apr 8,&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/04\/08\/functional-evaluation-of-proteolytic-activation-for-the-sars-cov-2-variant-b-1-1-7-role-of-the-p681h-mutation\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[38,159],"topic":[21],"class_list":["post-8851","post","type-post","status-publish","format-standard","hentry","category-article-summary","tag-transmission","tag-variants","topic-transmission"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/8851","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=8851"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/8851\/revisions"}],"predecessor-version":[{"id":8852,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/8851\/revisions\/8852"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=8851"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=8851"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=8851"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=8851"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}