{"id":8861,"date":"2021-04-08T11:21:08","date_gmt":"2021-04-08T18:21:08","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=8861"},"modified":"2021-04-13T10:52:42","modified_gmt":"2021-04-13T17:52:42","slug":"neutralizing-response-against-variants-after-sars-cov-2-infection-and-one-dose-of-bnt162b2","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/04\/08\/neutralizing-response-against-variants-after-sars-cov-2-infection-and-one-dose-of-bnt162b2\/","title":{"rendered":"Neutralizing Response against Variants after SARS-CoV-2 Infection and One Dose of BNT162b2"},"content":{"rendered":"<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">A single dose of the Pfizer-BioNTech vaccine substantially increased neutralizing activity against SARS-CoV-2 variants B.1.1.7, B.1.351, and P.1 among healthcare workers (HCWs) previously infected with SARS-CoV-2 (n=6). Serum samples from each HCW were obtained 1-12 weeks after natural infection, immediately before vaccination, and 1-2 weeks after vaccination and were tested using a microneutralization assay containing isolates of the parent strain and SARS-CoV-2 variants. Geometric mean titers (GMTs) for neutralizing activity were low prior to vaccination against the parent strain, B.1.1.7, P.1, and B.1.351 variants (GMTs: 81, 40, 36, and 7, respectively), but increased by 114-, 203-, 81-, and 228-fold after vaccination, respectively (corresponding GMTs: 9195, 8192, 2896, and 1625).<\/span><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Lustig et al.\u00a0(Apr 7, 2021). Neutralizing Response against Variants after SARS-CoV-2 Infection and One Dose of BNT162b2. New England Journal of Medicine. <\/span><\/i><a href=\"https:\/\/doi.org\/10.1056\/NEJMc2104036\"><span style=\"font-weight: 400\">https:\/\/doi.org\/10.1056\/NEJMc2104036<\/span><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A single dose of the Pfizer-BioNTech vaccine substantially increased neutralizing activity against SARS-CoV-2 variants B.1.1.7, B.1.351, and P.1 among healthcare workers (HCWs) previously infected with SARS-CoV-2 (n=6). Serum samples from each HCW were obtained 1-12 weeks after natural infection, immediately before vaccination, and 1-2 weeks after vaccination and were tested using a microneutralization assay containing&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/04\/08\/neutralizing-response-against-variants-after-sars-cov-2-infection-and-one-dose-of-bnt162b2\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[147,159],"topic":[31],"class_list":["post-8861","post","type-post","status-publish","format-standard","hentry","category-article-summary","tag-vaccination","tag-variants","topic-vaccines-and-immunity"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/8861","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=8861"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/8861\/revisions"}],"predecessor-version":[{"id":8862,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/8861\/revisions\/8862"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=8861"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=8861"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=8861"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=8861"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}