{"id":8865,"date":"2021-04-08T11:22:44","date_gmt":"2021-04-08T18:22:44","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=8865"},"modified":"2021-04-13T10:52:04","modified_gmt":"2021-04-13T17:52:04","slug":"single-prime-had5-spike-s-nucleocapsid-n-dual-antigen-vaccination-of-healthy-volunteers-induces-a-ten-fold-increase-in-mean-s-and-n-t-cell-responses-equivalent-to-t-cell-responses-from-patient","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/04\/08\/single-prime-had5-spike-s-nucleocapsid-n-dual-antigen-vaccination-of-healthy-volunteers-induces-a-ten-fold-increase-in-mean-s-and-n-t-cell-responses-equivalent-to-t-cell-responses-from-patient\/","title":{"rendered":"Single Prime HAd5 Spike (S) + Nucleocapsid (N) Dual Antigen Vaccination of Healthy Volunteers Induces a Ten-Fold Increase in Mean S- and N- T-Cell Responses Equivalent to T-Cell Responses from Patients Previously Infected with SARS-CoV-2"},"content":{"rendered":"<ul>\n<li style=\"font-weight: 400\"><i><span style=\"font-weight: 400\">[Pre-print, not peer-reviewed]<\/span><\/i><span style=\"font-weight: 400\"> Phase 1b trials for a novel adenovirus-vector COVID-19 vaccine (hAd5-S-Fusion+N-ETSD developed by ImmunityBio) containing the SARS-CoV-2 antigen spike (S) and nucleocapsid (N) proteins demonstrated a 10-fold increase in mean S- and N-specific T-cell responses from patients (n=4) with prior SARS-CoV-2 infection after a single dose. For context, currently approved vaccines only target the S protein. Modeling predictions suggest that the elicited T-cell responses could be robust against the parent SARS-CoV-2 strain and variants of concern.<\/span><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Sieling et al.\u00a0(Apr 7, 2021). Single Prime HAd5 Spike (S) + Nucleocapsid (N) Dual Antigen Vaccination of Healthy Volunteers Induces a Ten-Fold Increase in Mean S- and N- T-Cell Responses Equivalent to T-Cell Responses from Patients Previously Infected with SARS-CoV-2. Pre-print downloaded Apr 8 from <\/span><\/i><a href=\"https:\/\/www.medrxiv.org\/content\/10.1101\/2021.04.05.21254940v1\"><span style=\"font-weight: 400\">https:\/\/www.medrxiv.org\/content\/10.1101\/2021.04.05.21254940v1<\/span><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>[Pre-print, not peer-reviewed] Phase 1b trials for a novel adenovirus-vector COVID-19 vaccine (hAd5-S-Fusion+N-ETSD developed by ImmunityBio) containing the SARS-CoV-2 antigen spike (S) and nucleocapsid (N) proteins demonstrated a 10-fold increase in mean S- and N-specific T-cell responses from patients (n=4) with prior SARS-CoV-2 infection after a single dose. For context, currently approved vaccines only target&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/04\/08\/single-prime-had5-spike-s-nucleocapsid-n-dual-antigen-vaccination-of-healthy-volunteers-induces-a-ten-fold-increase-in-mean-s-and-n-t-cell-responses-equivalent-to-t-cell-responses-from-patient\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[142],"topic":[31],"class_list":["post-8865","post","type-post","status-publish","format-standard","hentry","category-article-summary","tag-vaccine","topic-vaccines-and-immunity"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/8865","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=8865"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/8865\/revisions"}],"predecessor-version":[{"id":8866,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/8865\/revisions\/8866"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=8865"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=8865"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=8865"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=8865"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}