{"id":8887,"date":"2021-04-09T11:37:58","date_gmt":"2021-04-09T18:37:58","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=8887"},"modified":"2021-04-12T11:38:50","modified_gmt":"2021-04-12T18:38:50","slug":"ultra-sensitive-severe-acute-respiratory-syndrome-coronavirus-2-sars-cov-2-antigen-detection-for-the-diagnosis-of-coronavirus-disease-2019-covid-19-in-upper-respiratory-samples","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/04\/09\/ultra-sensitive-severe-acute-respiratory-syndrome-coronavirus-2-sars-cov-2-antigen-detection-for-the-diagnosis-of-coronavirus-disease-2019-covid-19-in-upper-respiratory-samples\/","title":{"rendered":"Ultra-Sensitive Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Antigen Detection for the Diagnosis of Coronavirus Disease 2019 (COVID-19) in Upper Respiratory Samples"},"content":{"rendered":"<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">A study of a newly developed ultra-sensitive assay for detection of SARS-CoV-2 (S-PLEX, MesoScale Diagnostics) in upper respiratory samples (N=450) with a cycle threshold &lt;35 (higher concentration of virus) demonstrated 95-98% positive agreement and 93-96% negative agreement with RT-PCR. This study confirmed the findings of a previous study of the assay that was performed on frozen, stored samples. Advantages of S-PLEX include the ability to perform high-throughput testing, which can expedite testing in high-volume or surge settings, and provides another option for sensitive testing in settings where molecular testing supplies are scarce. However, the relatively lower negative agreement with RT-PCR suggests confirmatory testing may be required for samples with low-positive antigen levels.\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Wang et al. (Apr 8, 2021). Ultra-Sensitive Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Antigen Detection for the Diagnosis of Coronavirus Disease 2019 (COVID-19) in Upper Respiratory Samples. Clinical Infectious Diseases. <\/span><\/i><a href=\"https:\/\/doi.org\/10.1093\/cid\/ciab063\"><span style=\"font-weight: 400\">https:\/\/doi.org\/10.1093\/cid\/ciab063<\/span><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A study of a newly developed ultra-sensitive assay for detection of SARS-CoV-2 (S-PLEX, MesoScale Diagnostics) in upper respiratory samples (N=450) with a cycle threshold &lt;35 (higher concentration of virus) demonstrated 95-98% positive agreement and 93-96% negative agreement with RT-PCR. This study confirmed the findings of a previous study of the assay that was performed on&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/04\/09\/ultra-sensitive-severe-acute-respiratory-syndrome-coronavirus-2-sars-cov-2-antigen-detection-for-the-diagnosis-of-coronavirus-disease-2019-covid-19-in-upper-respiratory-samples\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[27],"topic":[19],"class_list":["post-8887","post","type-post","status-publish","format-standard","hentry","category-article-summary","tag-testing","topic-testing-and-treatment"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/8887","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=8887"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/8887\/revisions"}],"predecessor-version":[{"id":8888,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/8887\/revisions\/8888"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=8887"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=8887"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=8887"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=8887"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}