{"id":8894,"date":"2021-04-09T11:41:03","date_gmt":"2021-04-09T18:41:03","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=8894"},"modified":"2021-04-12T11:42:42","modified_gmt":"2021-04-12T18:42:42","slug":"poor-anti-sars-cov-2-humoral-and-t-cell-responses-after-2-injections-of-mrna-vaccine-in-kidney-transplant-recipients-treated-with-belatacept","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/04\/09\/poor-anti-sars-cov-2-humoral-and-t-cell-responses-after-2-injections-of-mrna-vaccine-in-kidney-transplant-recipients-treated-with-belatacept\/","title":{"rendered":"Poor Anti-SARS-CoV-2 Humoral and T-Cell Responses After 2 Injections of mRNA Vaccine in Kidney Transplant Recipients Treated with Belatacept"},"content":{"rendered":"<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">A study of kidney transplant recipients receiving belatacept (N=101), a drug to prevent organ rejection, found that humoral and T-cell immune response to the Pfizer-BioNTech vaccine was low. Only 2 patients developed spike antibodies 28 days after the first dose and 2 of 35 patients tested one month after the 2<\/span><span style=\"font-weight: 400\">nd<\/span><span style=\"font-weight: 400\"> dose developed antibodies. A specific T-cell response was observed in only 2 of 40 patients tested 28 days after the first dose and in 7 of 23 patients tested 1 month after the 2<\/span><span style=\"font-weight: 400\">nd<\/span><span style=\"font-weight: 400\"> dose. The authors recommend that kidney transplant recipients receiving belatacept should continue to maintain distancing and masking and household members should be vaccinated to maintain protection against COVID-19.<\/span><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Chavarot et al. (Apr 8, 2021). Poor Anti-SARS-CoV-2 Humoral and T-Cell Responses After 2 Injections of mRNA Vaccine in Kidney Transplant Recipients Treated with Belatacept. Transplantation. <\/span><\/i><a href=\"https:\/\/doi.org\/10.1097\/TP.0000000000003784\"><span style=\"font-weight: 400\">https:\/\/doi.org\/10.1097\/TP.0000000000003784<\/span><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A study of kidney transplant recipients receiving belatacept (N=101), a drug to prevent organ rejection, found that humoral and T-cell immune response to the Pfizer-BioNTech vaccine was low. Only 2 patients developed spike antibodies 28 days after the first dose and 2 of 35 patients tested one month after the 2nd dose developed antibodies. A&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/04\/09\/poor-anti-sars-cov-2-humoral-and-t-cell-responses-after-2-injections-of-mrna-vaccine-in-kidney-transplant-recipients-treated-with-belatacept\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[142],"topic":[31],"class_list":["post-8894","post","type-post","status-publish","format-standard","hentry","category-article-summary","tag-vaccine","topic-vaccines-and-immunity"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/8894","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=8894"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/8894\/revisions"}],"predecessor-version":[{"id":8895,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/8894\/revisions\/8895"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=8894"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=8894"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=8894"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=8894"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}