{"id":8933,"date":"2020-08-10T12:16:58","date_gmt":"2020-08-10T19:16:58","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=8933"},"modified":"2021-04-12T12:17:46","modified_gmt":"2021-04-12T19:17:46","slug":"genetic-variability-in-the-expression-of-the-sars-cov-2-host-cell-entry-factors-across-populations","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/08\/10\/genetic-variability-in-the-expression-of-the-sars-cov-2-host-cell-entry-factors-across-populations\/","title":{"rendered":"Genetic Variability in the Expression of the SARS-CoV-2 Host Cell Entry Factors across Populations"},"content":{"rendered":"<ul>\n<li><span data-contrast=\"auto\">Ortiz-Fern\u00e1ndez and Sawalha report significant variability in genetic determinants of the expression of ACE2 and TMPRSS2, two enzymes that might regulate the ability of SARS-CoV-2 to infiltrate host cells, among individuals and between populations.<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559685&quot;:360,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"16\" data-aria-posinset=\"1\" data-aria-level=\"2\"><span data-contrast=\"auto\">African populations showed a genetic predisposition for lower expression of both ACE2 and TMPRSS2<\/span><span data-contrast=\"auto\">\u00a0compared to<\/span><span data-contrast=\"auto\">\u00a0South or East Asians, Europeans<\/span><span data-contrast=\"auto\">, and an \u201cadmixed\u201d\u00a0<\/span><span data-contrast=\"auto\">American<\/span><span data-contrast=\"auto\">\u00a0population<\/span><span data-contrast=\"auto\">.<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559685&quot;:360,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Ortiz-Fern\u00e1ndez and Sawalha. (Aug 6,\u00a02020).\u00a0Genetic Variability in the Expression of the SARS-CoV-2 Host Cell Entry Factors across Populations. Genes &amp; Immunity.\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.1038\/s41435-020-0107-7\"><span data-contrast=\"none\">https:\/\/doi.org\/10.1038\/s41435-020-0107-7<\/span><\/a><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Ortiz-Fern\u00e1ndez and Sawalha report significant variability in genetic determinants of the expression of ACE2 and TMPRSS2, two enzymes that might regulate the ability of SARS-CoV-2 to infiltrate host cells, among individuals and between populations.\u00a0 African populations showed a genetic predisposition for lower expression of both ACE2 and TMPRSS2\u00a0compared to\u00a0South or East Asians, Europeans, and an&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/08\/10\/genetic-variability-in-the-expression-of-the-sars-cov-2-host-cell-entry-factors-across-populations\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[],"topic":[20],"class_list":["post-8933","post","type-post","status-publish","format-standard","hentry","category-article-summary","topic-clinical-characteristics-and-health-care-setting"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/8933","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=8933"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/8933\/revisions"}],"predecessor-version":[{"id":8934,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/8933\/revisions\/8934"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=8933"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=8933"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=8933"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=8933"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}