{"id":8937,"date":"2020-08-10T12:19:01","date_gmt":"2020-08-10T19:19:01","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=8937"},"modified":"2021-04-12T12:19:54","modified_gmt":"2021-04-12T19:19:54","slug":"first-in-human-trial-of-a-sars-cov-2-recombinant-spike-protein-nanoparticle-vaccine","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/08\/10\/first-in-human-trial-of-a-sars-cov-2-recombinant-spike-protein-nanoparticle-vaccine\/","title":{"rendered":"First-in-Human Trial of a SARS\u00a0CoV\u00a02 Recombinant Spike Protein Nanoparticle Vaccine"},"content":{"rendered":"<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"9\" data-aria-posinset=\"2\" data-aria-level=\"1\"><i><span data-contrast=\"none\">[pre-print, not peer-reviewed]\u00a0<\/span><\/i><span data-contrast=\"auto\">NVX-CoV2373, a recombinant nanoparticle vaccine, induced mean anti-spike IgG and neutralizing antibody responses that exceeded the mean responses in sera from convalescent COVID-19 patients with clinically significant illness. There were no serious adverse events and reactogenicity was mainly mild and not long-lasting.<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559685&quot;:360,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">\u00a0Keech et al. (Aug 6, 2020). First-in-Human Trial of a SARS\u00a0CoV\u00a02 Recombinant Spike Protein Nanoparticle Vaccine.\u00a0<\/span><\/i><i><span data-contrast=\"none\">Pre-print\u00a0downloaded\u00a0Aug 10 from<\/span><\/i><i><span data-contrast=\"none\">\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.1101\/2020.08.05.20168435\"><span data-contrast=\"none\">https:\/\/doi.org\/10.1101\/2020.08.05.20168435<\/span><\/a><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>[pre-print, not peer-reviewed]\u00a0NVX-CoV2373, a recombinant nanoparticle vaccine, induced mean anti-spike IgG and neutralizing antibody responses that exceeded the mean responses in sera from convalescent COVID-19 patients with clinically significant illness. There were no serious adverse events and reactogenicity was mainly mild and not long-lasting.\u00a0 \u00a0Keech et al. (Aug 6, 2020). First-in-Human Trial of a SARS\u00a0CoV\u00a02&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/08\/10\/first-in-human-trial-of-a-sars-cov-2-recombinant-spike-protein-nanoparticle-vaccine\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[],"topic":[31],"class_list":["post-8937","post","type-post","status-publish","format-standard","hentry","category-article-summary","topic-vaccines-and-immunity"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/8937","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=8937"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/8937\/revisions"}],"predecessor-version":[{"id":8938,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/8937\/revisions\/8938"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=8937"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=8937"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=8937"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=8937"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}